Noninvasive assessment of systolic and diastolic left ventricular function in patients with chronic severe anemia: A combined M-mode, two-dimensional, and Doppler echocardiographic study

Bahl, Vinay K.; Malhotra, O.P.; Kumar, Deepak; Agarwal, Ramesh; Goswami, Kewal C.; Bajaj, Rajiv; Shrivastava, Savitri

doi:10.1016/0002-8703(92)90066-5

Cited by 64 publications

(58 citation statements)

References 21 publications

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“…Significantly (p < 0.001) higher cardiac index was found in anemic patients (7.3±3.0 L/min/m 2 ) when compared with that of normal subjects (3.8 ± 1.6 L/min/m 2 ) (Bahl VK et al 1992). 7 A study was conducted by Schafer GE et al in 2002.…”

Section: Discussionmentioning

confidence: 83%

“…An increased left ventricular end diastolic dimension can be attributed towards the role of Frank Starling mechanism in the hyper dynamic state of chronic anemia. 7 In chronic anemia the hemodynamic adaptations causes changes in cardiac geometry.…”

Section: Discussionmentioning

confidence: 99%

“…7 A study was conducted by Schafer GE et al in 2002. Patients were divided into two groups: in patients with severe anemia (Hb 5.7±0.6 g/dl; n= 7).…”

Section: Discussionmentioning

confidence: 99%

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Left Vent R Icular Function Changes in Severe Anemia by Echocardiography: A Correlation Study

Qushnood¹,

Bhagoji²,

Quadri³

et al. 2014

jemds

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BACKGROUND AND OBJECTIVES:In the last decade, anemia is recognized as an important cause of morbidity, a factor limiting physical activity, responsible for a poor quality of life, and a predictor of unfavorable outcomes. Anemia is emerging as a potential contributor to the development and progression of cardiovascular disease. Hence the present study was undertaken to correlate echocardiographic changes with anemic status. METHODOLOGY: Present study was conducted in Al-Ameen Medical College and Government district Hospital, Bijapur. 31 anemic patients (aged 18-40 yrs.) with Hb ≤7 gm. % were selected. All anemic patients were subjected for hemoglobin estimation and M mode 2D Echocardiography. Echocardiographic parameters-IVSTd, LVIDd, LVPWd, IVSTs, LVIDs, LVPWS, EDV, ESV, SV, SI, CI, EF, FS were studied and correlated with hemoglobin levels. Statistical analysis was done by correlation analysis. RESULTS: LVPWd, IVSTs, IVStd, LVPWs did not correlate with hemoglobin levels. LVIDd, LVIDs, EDV, ESV, SV, SI, CI were negatively correlated with hemoglobin levels in anemic patients. No correlation observed for EF, FS. INTERPRETATION AND CONCLUSION:The findings of negative correlation of echo parameters with anemic status may be as a consequence of hyperdynamic circulatory state leading to vascular and cardiac changes. These changes are mainly due to increased preload, decreased afterload, changes in cardiac geometry. These factors increase systolic wall stress and over time lead to LV systolic dysfunction.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Left Vent R Icular Function Changes in Severe Anemia by Echocardiography: A Correlation Study

Qushnood¹,

Bhagoji²,

Quadri³

et al. 2014

jemds

View full text Add to dashboard Cite

show abstract

“…In addition, studies on the coronary blood flow in anemic patients have shown a decrease in myocardial oxygen consumption, despite an increase in myocardial workload and oxygen extraction. 18) Oxygen demand and supply mismatch can lead to myocardial ischemia and result in diastolic dysfunction.…”

Section: DI Is Sc Cu Us Ss Si Io On Nmentioning

confidence: 99%

Relation of Anemia to Echocardiographically Estimated Left Ventricular Filling Pressure in Hypertensive Patients Over 50 Year-Old

Kim

Pyun

Shin

2010

J Cardiovasc Ultrasound

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“…Bahl ve ark nın 31 kronik anemili hastayı değerlendirdikleri çalışmada 25 gösterildiği gibi ça-lışmamızda DEA hastalarında kontrol grubu ile karşılaştırıldığında sistolik fonksiyonları gösteren sol ventrikül sistol sonu çapı (LVESD) ve ejeksiyon fraksiyonu (EF) nda hafif artış olmakla beraber anlamlı fark saptanmadı. Tedavi sonrası da sistolik fonksiyonlarda belirgin değişme saptanmadı.…”

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The effects of iron deficiency anemia and its treatment on P wave durations and parameters of diastolic function

Şimşek¹,

Gümrükçüoğlu²,

Kaya³

et al. 2010

J Clin Exp Invest

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Objectives: We aimed to compare P wave variables and LV diastolic function between patient with iron deficiency anemia (IDA) and healthy control group and to investigate the effects of anemia treatment on these parameters. Materials and methods:The study included 56 patients having IDA without cardiovascular dissease and 50 healthy subjects. The cases were evaluated with clinical examination, ECG and transthoracic echocardiography (TTE) before and after treatment of IDA. Tissue Doppler imaging was assessed in addition to conventional TTE. The difference between maximum (Pmax) and minimum P wave duration on the 12-leads ECG was defined as PWD.Results: Compared to control group left atrium (LA) diameter (p=0.02), left ventricular enddiastolic diameter (LVED) (p=0.001), frequency of LV diastolic dysfunction (LVDD) (p=0.02), Pmax (p=0.002) and PWD (p=0.001) were significantly increased in patients with IDA. Correlations analysis revealed that PWD (r=0.367, p=0.001) and frequency of LVDD(r=0.231, p=0.02) were significantly correlated with severity of anemia. Compared to pre treatment period; LA diameter (p=0.001), LVED (p=0.001), frequency of LVDD (p=0.001), Pmax (p=0.001), Pmin (p=0.001) and PWD (p=0.001) were significantly decreased after treatment. Conclusion:IDA may be associated with increased PWD, left heart dimensions and frequency of LVDD in paralel with severity of anemia. These parameters may improve with treatment of anemia. J Clin Exp Invest 2010; 1(3): 187-194 Key words: Iron deficiency anemia, diastolic dysfunction, P wave dispersion ÖZET Amaç: Bu makalenin amacı kronik demir eksikliği anemisinin (DEA) hastaların sol ventrikül (SV) diyastolik fonksiyon parametreleri ile P dalga sürelerine etkisi ve anemi tedavisinin bu parametreler üzerinde yapabileceği deği-şiklikleri araştırmaktır. Gereç ve yöntem:Çalışmaya kalp-damar hastalığı olmayan 56 kronik DEA hastası ve 50 sağlıklı birey alın-dı. Vakalar başlangıçta ve anemi tedavi edildikten sonra anamnez, fizik muayene, elektrokardiyografi (EKG) ve transtorasik ekokardiyografi (TTE) ile değerlendirildi. TTE ile konvansiyonel parametrelerin yanı sıra doku doppler yapıldı. 12 derivasyonlu EKG de en uzun P dalga süre-sinden (Pmaks) en kısa P dalga süresi (Pmin) çıkarılarak P dalga dispersiyonu (PDD) hesaplandı. Bulgular: Kontrol grubuna göre, DEA hastalarında sol atriyum (SA) çapı (p=0.02), sol ventrikül diastol sonu çapı (LVDÇ) (p=0.001), diastolik disfonksiyon sıklığı (p=0.02), Pmaks (p=0.002) ve PDD (p=0.001) anlamlı derecede artmıştı. Korelasyon analizi ile diastolik disfonksiyon sık-lığının (r=0.231, p=0.02) ve PDD'nin (r=0.367, p=0.001) anemi derinliğiyle anlamlı derecede ilişkili olduğu saptandı. Tedavi öncesiyle kıyaslandığında tedavi sonrasında SA çapı (p=0.001), LVDÇ (p=0.001), diastolik disfonksiyon sıklığı (p=0.001), Pmaks (p=0.001), Pmin ( p=0.001) ve PDD (p=0.001) anlamlı derecede azalmıştı.Sonuç: DEA'nin şiddetine paralel olarak PDD, sol kalp boyutları ve SV diyastolik disfonksiyon sıklığının arttığı gözlendi. Aneminin tedavisiyle boz...

show abstract

Noninvasive assessment of systolic and diastolic left ventricular function in patients with chronic severe anemia: A combined M-mode, two-dimensional, and Doppler echocardiographic study

Cited by 64 publications

References 21 publications

Left Vent R Icular Function Changes in Severe Anemia by Echocardiography: A Correlation Study

Left Vent R Icular Function Changes in Severe Anemia by Echocardiography: A Correlation Study

Relation of Anemia to Echocardiographically Estimated Left Ventricular Filling Pressure in Hypertensive Patients Over 50 Year-Old

The effects of iron deficiency anemia and its treatment on P wave durations and parameters of diastolic function

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