Noninvasive assessment of preclinical atherosclerosis

Lane, H.; Smith, J. T.; Davies, J. S.

doi:10.2147/vhrm.2006.2.1.19

Cited by 99 publications

(83 citation statements)

References 172 publications

(169 reference statements)

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“…The early increase in IMT reflects the ongoing adaptive/maladaptive process to elevated intravascular shear stress (28). Several anthropometric and metabolic findings such as age, elevated blood pressure, central obesity, hyperlipidemia, and IR have been shown as independent determinants of IMT in different populations (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Delibaşı

Karbek²,

Bozkurt

et al. 2015

Arch. Endocrinol. Metab.

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Objective: To evaluate circulating E-selectin levels in patients with nonfunctional adrenal incidentaloma (NFA) in relation to insulin resistance and early atherosclerosis. Subjects and methods: A total of 40 patients with NFA (mean [SD] age: 55.6 [10.7] years; 70% were females) and 35 controls (mean [SD] age: 51.5 [8.1] years; 71.4% were females) selected from age-, gender-and body mass index (BMI)-matched healthy subjects were enrolled. Serum hsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated. High-resolution Bmode ultrasonography was performed. Serum levels of E-selectin were evaluated by enzyme-linked immunosorbent assay. Results: Patients with NFA had significantly higher values for E-selectin (14.9 (4.8) vs. 12.2 (4.1) ng/mL, p < 0.01) and CIMT (0.6 (0.1) vs. 0.5 (0.1) mm, p < 0.05) than controls. Serum E-selectin levels showed a statistically significant association with hsCRP (r = 0.751, p < 0.001), HOMA-IR (r = 0.575, p < 0.001) and CIMT (r = 0.762, p < 0.001). CIMT (Carotid intima media thickness) was increased in patients with NFA patients with NFA were more insulin resistant than controls and statistically significant relationship was found between size of tumor and HOMA-IR (r = 0.361, p < 0.001). Conclusion: In conclusion, based on significantly higher values for E-selectin, CIMT and HOMA-IR in patients with NFA than controls along with significant correlation of E-selectin levels to CIMT, HOMA-IR and hs-CRP, our findings seems to indicate an increased risk of early atherosclerosis and impaired endothelial function in NFA patients, particularly in case of insulin resistance. Arch Endocrinol Metab. 2015;59(4):310-7

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Section: Discussionmentioning

confidence: 99%

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Delibaşı

Karbek²,

Bozkurt

et al. 2015

Arch. Endocrinol. Metab.

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“…The central pressure waveform is important to determine left ventricular workload, which is relatively independent of the brachial pressure. This difference diminishes with age, and most people over 65 years of age have similar central and peripheral blood pressures 10 .…”

Section: Reflective Wave Phenomenonmentioning

confidence: 99%

“…The technique involves use of an applanation tonometer to record radial pulse wave 10 , simultaneously the central blood pressure and pulse wave velocity. These methods use various indices to describe the arterial stiffness ( Table 1).…”

Section: Arterial Stiffnessmentioning

confidence: 99%

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Pulse wave analysis and diabetes mellitus. A systematic review

Gajdova

Karásek

Goldmannová

et al. 2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Cardiovascular (CV) disease is the primary cause of death in diabetic patients and one of the explanations may be increased arterial stiffness. Arterial stiffness assessment using pulse wave analysis, is a predictive factor of CV events. The aim of this paper is to review the current knowledge of relations between diabetes mellitus and pulse wave analysis. A MEDLINE search was performed to retrieve both original and review articles addressing the relations and influences on arterial stiffness in diabetics. Pulse wave analysis is considered as a gold standard in CV risk evaluation for patients at risk, especially diabetics. Arterial stiffness assessment may be helpful for choosing more aggressive diagnostic and therapeutic strategies, particularly in younger patients to reduce the incidence of CV disease in these patients.

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“…2 Arterial stiffness has been consistently proven to be a predictor of adverse cardiovascular outcomes. 3 Stiffness index b is a measure of carotid arterial stiffness that is associated with coronary atherosclerosis 4,5 and vascular dysfunction 6 in patients with glucose intolerance and insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Relationship between carotid artery stiffness index, BNP and high-sensitivity CRP

Shroff

et al. 2009

J Hum Hypertens

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Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) are considered as novel biomarkers that are useful in the prediction of early cardiovascular risk. We studied the relationship between carotid artery stiffness index b and the cardiovascular biomarkers BNP and hs-CRP in 55 consecutive subjects. Carotid artery stiffness was assessed using the stiffness index b derived from brachial artery blood pressure measurement and carotid ultrasonography. Venous blood samples were obtained for BNP and hs-CRP. Pearson's correlation coefficient suggested a strong bivariate relationship between carotid stiffness index b and age (r ¼ 0.56, Po0.0001), BNP (r ¼ 0.45, Po0.004) and hs-CRP (r ¼ 0.26, P ¼ 0.06), respectively. On multiple regression analysis, significant correlations were found between carotid stiffness index b and age (P ¼ 0.004), BNP (P ¼ 0.027) and hs-CRP (P ¼ 0.029). These findings suggest that there is a relationship between intra-cardiac pressures (measured by BNP), vascular inflammation (measured by hs-CRP) and vascular stiffness. Cardiovascular biomarkers are thus associated with functional parameters of the vascular tree.

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Noninvasive assessment of preclinical atherosclerosis

Cited by 99 publications

References 172 publications

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Pulse wave analysis and diabetes mellitus. A systematic review

Relationship between carotid artery stiffness index, BNP and high-sensitivity CRP

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