Noninvasive assessment of peripheral microcirculation by near-infrared spectroscopy: a comparative study in healthy smoking and nonsmoking volunteers

Zamparini, G.; Butin, G.; Fischer, Marc-Olivier; Gérard, Jean-Louis; Hanouz, Jean‐Luc

doi:10.1007/s10877-014-9631-1

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…Recovery rates of NIRS oxygen signals have also been used to characterize reactive hyperemia, and we found the variability of the total rate of reperfusion to be similar to the CV values previously reported (CV calf ¼ 12.5 AE 10.7, CV foot ¼ 17.1 AE 10.9). 5,12,21,23,24,31,[43][44][45] Alternatively, our results identified R 2q as consistently the most reproducible measure of rate at both measurement sites. Furthermore, the R 3q measure was identified as the most reproducible second half rate with a CV of 8.35 and 11.75% in the calf and foot, respectively.…”

Section: Reproducibilitysupporting

confidence: 60%

“…[12][13][14][15][16][17][18] Specifically, continuous-wave NIRS (CW-NIRS) and frequency-domain NIRS devices have been used to noninvasively measure microvasculature function by observing the kinetics of NIRS signals during reactive hyperemia following a vascular occlusion. 5,12,16,[19][20][21][22][23][24] NIRS measures of reactive hyperemia correlate well with other measures of tissue perfusion, including conduit artery blood flow kinetics, transcutaneous oximetry, and plethysmography. 12,13,20,[25][26][27] Additionally, studies have found baseline oxygen saturation and reperfusion rates during reactive hyperemia to be predictors of mortality in critically ill patients.…”

Section: Introductionmentioning

confidence: 71%

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Measuring reactive hyperemia in the lower limb using near-infrared spectroscopy

2016

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Near-infrared spectroscopy (NIRS) has been used to measure reactive hyperemia following a vascular occlusion. However, the procedures and methods of analysis used have varied. The purpose of the present study is to identify reproducible methods for measuring reactive hyperemia using HbO2 NIRS signals in the calf and foot. Healthy participants (10 male, 10 female) aged 19 to 28 years performed one of two tests: reproducibility trials or elevation protocol (30 and 60 cm limb elevation above the heart). The time to 50% reperfusion (T1/2) and the second (R2q) quartile rates of reperfusion were found to be the most reproducible parameters (coefficient of variation= 7.12 to 14.1%). The time to 95% reperfusion (T95) was 12.7% more reproducible on average than the previously reported parameter of time to peak hyperemia. Measures of reperfusion time and rate slowed with increasing limb elevation. Correlations were identified between the calf and foot in the measurements of R2q (R2 = 0.713, p = 0.021), T1/2 (R2 = 0.673, p = 0.033), and T95 (R2 = 0.792, p = 0.006). Half and 95% recovery times and second and third quartile rates expressed good reproducibility and sensitivity to change with reduced perfusion pressure. NIRS measures of reactive hyperemia have the potential to evaluate microvascular perfusion in clinical populations.

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Section: Reproducibilitysupporting

confidence: 60%

Section: Introductionmentioning

confidence: 71%

Measuring reactive hyperemia in the lower limb using near-infrared spectroscopy

2016

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“…Moreover, the additive information regarding vasodilatory stimulus that this approach provides, compared with other more traditional measures, shines new light on an old problem and opens new possibilities for cardiovascular research across the health continuum. The NIRS-derived post-occlusion tissue oxygen saturation recovery kinetics has previously been used to assess peripheral microvascular function across the disease continuum, including healthy young subjects (Bopp et al 2011(Bopp et al , 2014Fellahi et al 2014), patients with peripheral artery disease (Kragelj et al 2001), tobacco users (Zamparini et al 2015) and patients with sepsis (Doerschug et al 2007;Mayeur et al 2011). To our knowledge, this is the first study to use this approach to assess age-related microvascular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…skeletal muscle) directly, increasing its overall specificity. To date, several studies have evaluated tissue oxygen saturation (S tO 2 ) kinetics following circulatory occlusion in healthy young subjects (Bopp et al 2011(Bopp et al , 2014Fellahi et al 2014), patients with peripheral artery disease (Kragelj et al 2001), tobacco users (Zamparini et al 2015) and patients with sepsis (Doerschug et al 2007;Mayeur et al 2011). The results suggest that NIRS-derived post-occlusion tissue oxygen saturation kinetics is a robust and easy-to-use approach to evaluate vascular function in vivo.…”

Section: Introductionmentioning

confidence: 99%

Age‐related microvascular dysfunction: novel insight from near‐infrared spectroscopy

Rosenberry

Munson

Chung

et al. 2017

Experimental Physiology

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What is the central question of this study? Can near-infrared spectroscopy (NIRS)-derived post-occlusion tissue oxygen saturation recovery kinetics be used to study age-related impairments in microvascular function? What is the main finding and its importance? Using a previously established 5 min cuff occlusion protocol, we found that NIRS-derived indices of microvascular function were markedly reduced in elderly compared with young participants. However, when we controlled for the absolute level of vasodilatory stimulus and matched the tissue desaturation level between groups, we found similar responses in young and elderly participants. Overall, these data highlight the important role NIRS can serve in clinical vascular biology, but also establish the need for assessing tissue ischaemia during cuff occlusion protocols. Near-infrared spectroscopy (NIRS) has emerged as a promising tool to evaluate vascular reactivity in vivo. Whether this approach can be used to assess age-related impairments in microvascular function has not been tested. Tissue oxygen saturation (StO2) post-occlusion recovery kinetics were measured in two distinct age groups (<35 and >65 years of age) using NIRS placed over the flexor digitorum profundus. Key end-points included the following: (i) the desaturation rate during cuff occlusion; (ii) the lowest StO2 value obtained during ischaemia (StO2min); (iii) StO2 reperfusion rate; (iv) the highest StO2 value reached after cuff release (StO2max); and (v) the reactive hyperaemia area under the curve (AUC). At first, using a conventional 5 min cuff occlusion protocol, the elderly participants achieved a much slower rate of oxygen recovery (1.5 ± 0.2 versus 2.5 ± 0.2% s ), lower StO2max (85.2 ± 2.9 versus 92.3 ± 1.5%) and lower reactive hyperaemia AUC (2651.8 ± 307.0 versus 4940.0 ± 375.8% s ). However, owing to a lower skeletal muscle resting metabolic rate, StO2min was also significantly attenuated in the elderly participants compared with the young control subjects (55.7 ± 3.5 versus 41.0 ± 3.4%), resulting in a much lower ischaemic stimulus. To account for this important difference between groups, we then matched the level of tissue ischaemia in a subset of young healthy participants by reducing the cuff occlusion protocol to 3 min. Remarkably, when we controlled for tissue ischaemia, we observed no differences in any of the hyperaemic end-points between the young and elderly participants. These data highlight the important role NIRS can serve in vascular biology, but also establish the need for assessing tissue ischaemia during cuff occlusion protocols.

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“…Two studies published in the JCMC last year used the VOT in combination with peripheral NIRS measurements [ 23 , 24 ]. In the first study, Zamparini et al [ 24 ] examined if the VOT could be used to differentiate NIRS-derived vascular reactivity between smokers and non-smokers.…”

Section: Combined Monitoring Of Microcirculation and Tissue Oxygenatimentioning

confidence: 99%

Journal of Clinical Monitoring and Computing 2015 end of year summary: tissue oxygenation and microcirculation

Scheeren

2016

J Clin Monit Comput

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Last year we started this series of end of year summaries of papers published in the 2014 issues of the Journal Of Clinical Monitoring And Computing with a review on near infrared spectroscopy (Scheeren et al. in J Clin Monit Comput 29(2):217–220, 2015). This year we will broaden the scope and include papers published in the field of tissue oxygenation and microcirculation, or a combination of both entities. We present some promising new technologies that might enable a deeper insight into the (patho)physiology of certain diseases such as sepsis, but also in healthy volunteers. These may help researchers and clinicians to evaluate both tissue oxygenation and microcirculation beyond macro-hemodynamic measurements usually available at the bedside.

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Noninvasive assessment of peripheral microcirculation by near-infrared spectroscopy: a comparative study in healthy smoking and nonsmoking volunteers

Cited by 15 publications

References 23 publications

Measuring reactive hyperemia in the lower limb using near-infrared spectroscopy

Measuring reactive hyperemia in the lower limb using near-infrared spectroscopy

Age‐related microvascular dysfunction: novel insight from near‐infrared spectroscopy

Journal of Clinical Monitoring and Computing 2015 end of year summary: tissue oxygenation and microcirculation

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