Noninvasive assessment of language dominance in children and adolescents with functional MRI

Hertz-Pannier, Lucie; Gaillard, W. D.; Mott, Stephen H.; Cuenod, Charles‐André; Bookheimer, Susan Y.; Weinstein, Steven L.; Conry, Joan A.; Papero, P. H.; Schiff, Steven J.; Bihan, Denis Le; Theodore, W. H.

doi:10.1212/wnl.48.4.1003

Cited by 325 publications

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“…Our findings confirm the clinical utility of the fMRI tasks used in this study for localization of the eloquent cortex in presurgical evaluation, and are consistent with prior literature. Several studies have already documented the ability of fMRI to lateralize language in patients with epilepsy, and have shown a strong correlation between presurgical fMRI performed using various language tasks and IAP [14,16,18,23,24,29]. For example, Binder and colleagues found a very strong correlation (Pearson's r = 0.96, P < 0.0001), and Desmond and colleagues observed a perfect ("100%") correlation between the IAP and fMRI in the ability to lateralize language in patients with epilepsy [14,16].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, several studies have compared fMRI and the IAP with respect to language lateralization, or evaluated the ability of fMRI to localize language functions in children and adults with epilepsy [12][13][14][15][16][17][18][19][20][21][22][23][24]. These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31].…”

Section: Introductionmentioning

confidence: 99%

“…These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31]. Some studies have also reported the use of more than one fMRI paradigm for language localization and lateralization [10,12,13,29,32,33], but the results of these studies have been mixed, with some tasks showing good and some poor correlation with the results of IAP.…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Szaflarski

Holland

Jacola

et al. 2008

Epilepsy & Behavior

112

137

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Functional magnetic resonance imaging (fMRI) has the potential to replace the intracarotid amobarbital procedure (IAP) in presurgical evaluation of patients with epilepsy patients. In this study, we compared fMRI verb generation (VG) and semantic decision/tone decision (SDTD) tasks and the IAP in their ability to localize language functions in patients with epilepsy undergoing presurgical evaluation. We enrolled 50 healthy controls to establish normal language activation patterns for VG and SDTD tasks at 3 or 4 T, and to design language regions of interest (ROIs) that were later applied to 38 patients with epilepsy (28 of 38 also underwent the IAP). We calculated laterality indices (LIs) for each task for each subject based on the ROIs, and we used general linear modeling to analyze the fMRI data. All healthy and epileptic subjects activated language areas with both fMRI tasks. We found significant correlations in language lateralization between the fMRI tasks (r = 0.495, P ≤ 0.001) and between VG and IAP (r = 0.652, P < 0.001) and SDTD and IAP (r = 0.735, P < 0.001). The differences in LIs between SDTD and VG tasks were small and not affected by age, gender, epilepsy status, handedness, or performance. SDTD and VG tasks combined explained approximately 58.4% in the variability of the IAP/language. In the general linear modeling, only the SDTD task significantly contributed to the determination of language lateralization in patients with epilepsy undergoing presurgical evaluation. Results indicate a moderate convergent validity between both fMRI language tasks and between IAP and fMRI tasks. The results of this study indicate that either of these fMRI tasks can be used for language lateralization in patients with epilepsy undergoing presurgical evaluation, but that the SDTD task is likely to provide more information regarding language lateralization than the VG task.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Szaflarski

Holland

Jacola

et al. 2008

Epilepsy & Behavior

112

137

View full text Add to dashboard Cite

show abstract

“…Second, we hypothesized that frontohippocampal activity would be involved in learning a new set of response locations. Finally, based on our own work and that of others (Casey et al, 1997b;Hertz-Pannier et al, 1997), we hypothesized that activity associated with forming new associations would be more diffuse and less focal for children in these respective frontostriatal and hippocampal circuits, but that similar brain regions would be recruited across age groups. Thus, the current study examines the development of neural circuitry involved in overriding a stimulus-response mapping and learning a new one using functional magnetic resonance imaging (fMRI) and a stimulus-response compatibility task.…”

Section: Abstract: Development; Basal Ganglia; Hippocampus; Imaging;mentioning

confidence: 99%

Dissociating Striatal and Hippocampal Function Developmentally with a Stimulus–Response Compatibility Task

et al. 2002

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The current study examined the development of cognitive and neural systems involved in overriding a learned action in favor of a new one using a stimulus-response compatibility task and functional magnetic resonance imaging. Eight right-handed adults (mean age, 22-30 years), and eight children (7-11 years) were scanned while they performed a task. Both children and adults were less accurate for incompatible stimulus-response mappings than compatible ones; the children's performance was significantly worse. The comparison of the incompatible and compatible conditions showed large volumes of activity in the ventral prefrontal cortex, ventral caudate nucleus, thalamus, and hippocampus. Striatal activity correlated with the percentage of errors in overriding the old stimulus-response association. The hippocampal activity correlated with the reaction time to make a response to a new stimulus-response mapping that required the reversal of a prior association between a stimulus and a response location. Developmental differences were observed in the volume of striatal/pallidal and hippocampal/parahippocampal activity in that these regions were larger and extended more ventrally in children relative to adults. These results suggest that with maturation and learning, projections to and from these regions may become more refined and focal. Moreover, these findings are consistent with the role of ventral frontostriatal circuitry in overriding habitual and well learned actions and hippocampal systems in learning and reversing associations between a given stimulus and spatial location. Key words: development; basal ganglia; hippocampus; imaging; learning; fMRI; childrenThe ability to override competing actions is a key component of cognitive functioning (Kahneman et al., 1983;Baddeley, 1986;Shallice, 1988;Cohen and Servan-Schreiber, 1992;Desimone and Duncan, 1995); it becomes more efficient with age (Harnishfeger and Bjorkland, 1993). In other words, immature cognition is characterized by greater susceptibility to interference from competing actions (Diamond, 1990;Brainerd and Reyna, 1993;Dempster, 1993;Casey et al., 2001Casey et al., , 2002Munakata and Yerys, 2001), as evidenced in children when performing Stroopinterference tasks (Tipper et al., 1989), card sorting (Zelazo et al., 1996;Munakata and Yerys 2001), and go-no-go tasks (Luria, 1961; Casey et al., 1997a,b;Vaidya et al., 1998). In all cases, children have more difficulty making the correct response when there is interference from competing response alternatives.Overriding well learned actions in favor of new ones and the development of neural subsystems underlying this ability is the focus of this paper. In essence, how does the less mature system recruit brain regions when making a new response to a given stimulus relative to making a well learned response to that same stimulus (i.e., stimulus-response incompatibility)? This ability involves both overriding an old association while simultaneously learning a new one. The ability to shift between behavioral sets has...

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“…This example of initial diffuse cortical activity early in learning, followed by an increase in focal activity, parallels results from developmental fMRI studies. These studies show diffuse activity in children relative to adolescents and adults, with adolescents showing the greatest focal activity during performance of behavioral tasks, even when performance across groups is equated [24][25][26][27][28][29].…”

Section: Neural Changes During Learningmentioning

confidence: 90%

Developmental cognitive neuroscience: progress and potential

Munakata

Casey

Diamond

2004

Trends in Cognitive Sciences

109

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Noninvasive assessment of language dominance in children and adolescents with functional MRI

Abstract: fMRI can be used to assess language lateralization noninvasively in children. It has the potential to replace current functional mapping techniques in patients, and to provide important data on brain development.

Cited by 325 publications

References 0 publications

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Dissociating Striatal and Hippocampal Function Developmentally with a Stimulus–Response Compatibility Task

Developmental cognitive neuroscience: progress and potential

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