Noninstrumented Lumbar Fusion with Bone Morphogenetic Proteins for Spinal Stenosis with Spondylolisthesis in the Elderly

Bindal, Shivani; Bindal, Shray K.; Bindal, Mohini; Bindal, Ajay K.

doi:10.1016/j.wneu.2019.02.251

Cited by 7 publications

(24 citation statements)

References 28 publications

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“…There is a coupling media between the imaging target and the transducer. Water and ultrasound gel are the most common couplant 56 . More details about acoustic couplants can be found in Appendix C. This script can be modified to be used with other probes.…”

Section: Us/pa Experimental Setup and System Characterizationmentioning

confidence: 99%

Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system

Kratkiewicz¹,

Manwar²,

Zhou³

et al. 2021

Biomed. Opt. Express

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Significance: Photoacoustic imaging (PAI) is an emerging functional and molecular imaging technology that has attracted much attention in the past decade. Recently, many researchers have used the Vantage Verasonics® research system for simultaneous ultrasound (US) and photoacoustic (PA) imaging. This was the motivation to write on the details of US/PA imaging system implementation and characterization using Verasonics platform. Aim:We describe the subtle details of US/PA imaging system setup, study the performance parameters of the system, and explain sequencing of the US/PA signal generation and signal amplification as well as the details required for efficient use of the hardware of the system and data processing protocols. Approach:We focused on linear-array based PAI due to its popularity and simple setup, as well as its high potential for clinical translatability. Results:We have shown the sequencing of the US/PA signal generation, signal amplification, and related data processing protocols. A step-by-step guideline to develop and characterize PAI system using Vantage 128 has been presented. Some of the limitations of the vantage system are also listed. Conclusions:Photoacoustic imaging is a complement to the already established US imaging technique and may significantly increase its scope of application in diagnostic imaging and therapeutic monitoring. Combining with commercial medical US systems, the development of PAI can be accelerated by taking advantage of US image reconstruction and processing. With the information we presented in the body of this review and the four appendices, we described most of the experimental considerations one should know when working with the Vantage system for PAI tests.

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Section: Us/pa Experimental Setup and System Characterizationmentioning

confidence: 99%

Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system

Kratkiewicz¹,

Manwar²,

Zhou³

et al. 2021

Biomed. Opt. Express

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“…There are also various applications of BMPs and TGFβs in clinics with carrier molecules [51,[75][76][77][78][79][80][81][82][83][84]. However, the locally applied supraphysiological BMP-2 doses during surgery is reported to be connected with hematoma formation in soft tissue, increased inflammatory response, bone cysts and infection [85] which also increase the importance of clinical follow-up studies.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Nevertheless, these complications did not prevent the use of these cytokines in the clinics because the clinical studies showed better results with BMP-2 than autogenous bone grafting alone [20,92]. The advantage of increased rate in spinal fusion with the combination of BMPs [20,56,76,78,79,91] and BMPs' having high capacity for bone regeneration and capability of fracture healing keep them popular in bone regeneration studies and make them a popular research area also in basic science in order to find suitable carriers for these cytokines to be released in a sustained manner with a decrease in required dose for bone regeneration. Thus, it is an important research area to find new materials to fill bone defects and/or to support the instruments that are used to stabilize the bone while supporting bone regeneration and the sustained release of the cytokine and/or to understand the signaling pathways of cytokines, how they work in cellular level on differentiation and proliferation in order to prevent the probable progression of a disease before it needs a replacement surgery.…”

Section: Perspectivementioning

confidence: 99%

BMP and TGFβ use and release in bone regeneration

et al. 2020

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A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion cases also need special monitoring for healing. Bone tissue regeneration can be attained by autografts, allografts, xenografts and synthetic materials, however their limited availability and the increased surgical time as well as the donor site morbidity of autograft use, and lower probability of success, increased costs and disease transmission and immunological reaction probability of allografts oblige us to find better solutions and new grafts to overcome the cons. A proper biomaterial for regeneration should be osteoinductive, osteoconductive, biocompatible and mechanically suitable. Cytokine therapy, where growth factors are introduced either exogenously or triggered endogenously, is one of the commonly used method in bone tissue engineering. Transforming growth factor β (TGFβ) superfamily, which can be divided structurally into two groups as bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs) and TGFβ, activin, Nodal branch, Mullerian hormone, are known to be produced by osteoblasts and other bone cells and present already in bone matrix abundantly, to take roles in bone homeostasis. BMP family, as the biggest subfamily of TGFβ superfamily, is also reported to be the most effective growth factors in bone and development, which makes them one of the most popular cytokines used in bone regeneration. Complications depending on the excess use of growth factors, and pleiotropic functions of BMPs are however the main reasons of why they should be approached with care. In this review, the Smad dependent signaling pathways of TGFβ and BMP families and their relations and the applications in preclinical and clinical studies will be briefly summarized.

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“…Secondly, the neural foramens, which are openings through which the nerve roots exit the spinal cord, can be compressed as a result of disk herniation, hypertrophy of the facet joints and ligaments, or unstable slippage of one vertebral body relative to the level below. Lastly, the lateral recess, which is seen in the lumbar spine only and is defined as the area long the pedicle that a nerve root enters just before its exit through the neural foramen, can be compressed from a facet joint hypertrophy [1,2,3] . Depending on the level of the spine affected, each type of compression can lead to different symptoms that warrant a particular treatment modality.…”

Section: Introductionmentioning

confidence: 99%

Operative outcomes of decompression in degenerative lumbar canal stenosis

Solanki¹,

Sureja²,

Patel³

et al. 2022

Int. J. Orthop. Sci.

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Background: Spinal canal stenosis is a condition in which the spinal cord and the nerve roots are compressed by a number of pathologic factors, leading to symptoms such as pain, numbness, and weakness. This study was undertaken to evaluate clinical, functional and radiological outcomes of surgical decompression in spinal canal stenosis. Material and Method:We have included 26 adult patients with lumbar spinal canal stenosis in this prospective study who have not improved after conservative management for minimum 6 weeks. All the patients underwent standard open decompression using posterior midline approach. Patients were followed up at 6 weeks, 3 months, 6 months, and 1 year, they were assessed clinically and functionally using VAS score and ODI score. Results: In this study total 26 patients, out of which, 14(54%) were females and 12(46%) were males with an average age of 58.08 years. VAS of back pain improved from 2.85 on admission to 1.08 on final follow-up and leg pain form 8.00 on admission to 1.73 on final follow-up and ODI from 63.69 on admission to 14.54 on final follow-up. Conclusion: Decompression surgery is the gold standard treatment for central or lateral recess lumbar stenosis when conservative treatment fails as it provides significant clinical as well as functional improvement in term of VAS score and Oswestry Disability Index.

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Noninstrumented Lumbar Fusion with Bone Morphogenetic Proteins for Spinal Stenosis with Spondylolisthesis in the Elderly

Cited by 7 publications

References 28 publications

Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system

Technical considerations in the Verasonics research ultrasound platform for developing a photoacoustic imaging system

BMP and TGFβ use and release in bone regeneration

Operative outcomes of decompression in degenerative lumbar canal stenosis

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