Nonglutaraldehyde treated porcine pericardium with good biocompatibility, reduced calcification and improved Anti-coagulation for bioprosthetic heart valve applications

Yu, Tao; Chen, Xiaotong; Zhuang, Weihua; Tian, Yuan; Liang, Zhen; Kong, Qunshou; Hu, Cheng; Li, Gaocan; Wang, Yunbing

doi:10.1016/j.cej.2021.128900

Cited by 20 publications

(20 citation statements)

References 45 publications

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“…6 Recent studies showed that the pathogenesis of SVD involves multiple active processes, which are heavily related to the cytotoxicity, thrombosis, protein deposition, immune response, calcification and endothelialization. 7 The immunogenicity of xenografts can be reduced by Glut cross-linking, while the current study shows that Glut treatment is insufficient to eliminate the immune response completely from the host. The foreign body reaction is considered as a nonspecific immune reaction during the implantation, which can be further enhanced by the nonspecific adhesion of serum proteins on the implanted surface.…”

Section: Introductionmentioning

confidence: 67%

Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

et al. 2022

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Section: Introductionmentioning

confidence: 67%

Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

et al. 2022

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“…A kind of nonglutaraldehyde-treated porcine pericardium treated with a bicyclic oxazolidine (OXOH) for the application of BHVs has been developed for the first time by Wang and co-workers (Figure 4). [108,109] Compared to the Glut-treated porcine pericardium, great biocompatibility, reduced anticalcification, improved anticoagulation, and proliferation of endothelial cells along with the similar satisfactory mechanical properties were proved for the OXOH-crosslinked porcine pericardium. Furthermore, the transcatheter aortic valve from OXOHcrosslinked porcine pericardium has also been manufactured, exhibiting desirable hydrodynamic and fatigue performance and great potential in the clinical application for BHVs.…”

Section: Nonglutaraldehyde Crosslinked Bhvsmentioning

confidence: 99%

“…Illustration of nonglutaraldehyde crosslinker OX-OH for bioprosthetic heart valve preparation with better biocompatibility, improved anticoagulation, reduced calcification, and enhanced endothelial cell adhesion properties. Reproduced with permission [108]. Copyright 2021, Elsevier.…”

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confidence: 99%

Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases

Wang

Yang

et al. 2022

Advanced Materials

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Cardiovascular diseases have become the leading cause of death worldwide. The increasing burden of cardiovascular diseases has become a major public health problem and how to carry out efficient and reliable treatment of cardiovascular diseases has become an urgent global problem to be solved. Recently, implantable biomaterials and devices, especially minimally invasive interventional ones, such as vascular stents, artificial heart valves, bioprosthetic cardiac occluders, artificial graft cardiac patches, atrial shunts, and injectable hydrogels against heart failure, have become the most effective means in the treatment of cardiovascular diseases. Herein, an overview of the challenges and research frontier of innovative biomaterials and devices for the treatment of cardiovascular diseases is provided, and their future development directions are discussed.

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“…Heart valve diseases are one of the critical factors causing high morbidity and mortality of cardiovascular diseases. [207] Tissue engineering heart valve is a novel idea for the development of artificial valve and the optimal option in valve surgery. Liu et al [51] fabricated PCL valve stents by coating 3D-printed valve cores with the PCL electrospinning membrane.…”

Section: Membranesmentioning

confidence: 99%

Combination of 3D Printing and Electrospinning Techniques for Biofabrication

Fazal

Wang

Radacsi

2022

Adv Materials Technologies

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This review presents the different combination methods of 3D printing and electrospinning processes and discusses the advantages of each method. Also, the applications of products of the hybrid process in the biomedical field, including tissue engineering and regenerative medicine, are thoroughly discussed. 3D printing and electrospinning are separate approaches for generating structured materials in a variety of biomedical applications. However, some shortfalls, such as the low resolution of 3D printing and uncontrollable shape of electrospun products, limits their application performances. Therefore, new ideas that combine 3D printing and electrospinning methods are proposed to give full play to their strengths and mitigate their weaknesses, which provide an effective and powerful platform for fabricating novel structural materials. Finally, a future vision regarding challenges and perspectives in the combination of 3D printing and electrospinning techniques is proposed.

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Nonglutaraldehyde treated porcine pericardium with good biocompatibility, reduced calcification and improved Anti-coagulation for bioprosthetic heart valve applications

Cited by 20 publications

References 45 publications

Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases

Combination of 3D Printing and Electrospinning Techniques for Biofabrication

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