Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

Liang, Xuyue; Lei, Yang; Ding, Kailei; Huang, Xueyu; Cheng, Zheng; Wang, Yunbing

doi:10.1039/d2tb01826h

Cited by 5 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liang et al 2022 [ 210] PP PMEA coating by copolymerization Enhanced anticoagulant, anti-inflammatory, and anti-calcification properties Wu et al 2018 [ 191] PP Extracellular matrix coating Immune response, potentially induce tissue regeneration, and improved biocompatibility Liu et al 2021 [ 211] PP Zwitterionic copolymer modification based on MPC Improved anti-coagulant and anti-calcification properties Marinval et al 2018 [ 212] PHV Fucoidan/VEGF-based surface modification…”

Section: Authors Years Bioprosthesis Materials Modification Strategie...mentioning

confidence: 99%

Recent Advances in the Modification and Improvement of Bioprosthetic Heart Valves

Tong,

Cai,

Wang

et al. 2024

Small

Self Cite

View full text Add to dashboard Cite

Valvular heart disease (VHD) has become a burden and a growing public health problem in humans, causing significant morbidity and mortality worldwide. An increasing number of patients with severe VHD need to undergo heart valve replacement surgery, and artificial heart valves are in high demand. However, allogeneic valves from donors are lacking and cannot meet clinical practice needs. A mechanical heart valve can activate the coagulation pathway after contact with blood after implantation in the cardiovascular system, leading to thrombosis. Therefore, bioprosthetic heart valves (BHVs) are still a promising way to solve this problem. However, there are still challenges in the use of BHVs. For example, their longevity is still unsatisfactory due to the defects, such as thrombosis, structural valve degeneration, calcification, insufficient re‐endothelialization, and the inflammatory response. Therefore, strategies and methods are needed to effectively improve the biocompatibility and longevity of BHVs. This review describes the recent research advances in BHVs and strategies to improve their biocompatibility and longevity.

show abstract

Section: Authors Years Bioprosthesis Materials Modification Strategie...mentioning

confidence: 99%

Recent Advances in the Modification and Improvement of Bioprosthetic Heart Valves

Tong,

Cai,

Wang

et al. 2024

Small

Self Cite

View full text Add to dashboard Cite

show abstract

“…53,54 X-coating, or poly(2-methoxyethyl acrylate) (PMEA), has a hydrophobic polyethylene backbone on its lowest layer and a biologically inert hydrophilic layer on its surface; it is also an amphiphilic polymer with excellent hemocompatibility and can resist protein adsorption and platelet activation. 55 Marcoux et al showed that patients in the X-coating group spent significantly more time in the ICU for treatment and with ventilators, resulting in worse clinical outcomes than patients treated with Bioline, Trillium, and Phisio coatings. 28 The Balance Biosurface coating contains negatively charged sulfonated polymers that can contribute to anticoagulation and PEO which can ensure hydrophilicity.…”

Section: Biopassive Coatings For Commercial Usementioning

confidence: 99%

Commercial and novel anticoagulant ECMO coatings: a review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Such outcomes indicate that inhibiting the formation of thrombi not only enhances hemocompatibility but also bolsters the performance of medical devices. This is achieved by mitigating the risk of extreme immune reactions triggered by hyperactivation, which in turn supports more effective tissue regeneration (Hu et al, 2020;Liang et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modifications

Rodríguez-Soto,

Suárez Vargas,

Ayala-Velásquez

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Introduction: Thrombogenesis, a major cause of implantable cardiovascular device failure, can be addressed through the use of biodegradable polymers modified with anticoagulating moieties. This study introduces a novel polyester urethane urea (PEUU) functionalized with various anti-platelet deposition molecules for enhanced antiplatelet performance in regenerative cardiovascular devices.Methods: PEUU, synthesized from poly-caprolactone, 1,4-diisocyanatobutane, and putrescine, was chemically oxidized to introduce carboxyl groups, creating PEUU-COOH. This polymer was functionalized in situ with polyethyleneimine, 4-arm polyethylene glycol, seleno-L-cystine, heparin sodium, and fondaparinux. Functionalization was confirmed using Fourier-transformed infrared spectroscopy and X-ray photoelectron spectroscopy. Bio-compatibility and hemocompatibility were validated through metabolic activity and hemolysis assays. The anti-thrombotic activity was assessed using platelet aggregation, lactate dehydrogenase activation assays, and scanning electron microscopy surface imaging. The whole-blood clotting time quantification assay was employed to evaluate anticoagulation properties.Results: Results demonstrated high biocompatibility and hemocompatibility, with the most potent anti-thrombotic activity observed on pegylated surfaces. However, seleno-L-cystine and fondaparinux exhibited no anti-platelet activity.Discussion: The findings highlight the importance of balancing various factors and addressing challenges associated with different approaches when developing innovative surface modifications for cardiovascular devices.

show abstract

Poly(2-methoxyethyl acrylate) coated bioprosthetic heart valves by copolymerization with enhanced anticoagulant, anti-inflammatory, and anti-calcification properties

Abstract: With the emergence of transcatheter aortic valve replacement (TAVR), commercial glutaraldehyde (Glut) cross-linked bioprosthetic heart valves (BHVs) fabricated from the xenogeneic pericardium have become the most popular choice for treating heart valve diseases.

Cited by 5 publications

References 35 publications

Recent Advances in the Modification and Improvement of Bioprosthetic Heart Valves

Recent Advances in the Modification and Improvement of Bioprosthetic Heart Valves

Commercial and novel anticoagulant ECMO coatings: a review

Polyester urethane urea (PEUU) functionalization for enhanced anti-thrombotic performance: advancing regenerative cardiovascular devices through innovative surface modifications

Contact Info

Product

Resources

About