Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissues

Watson, Cheryl S.; Alyea, Rebecca A.; Jeng, Yow‐Jiun; Kochukov, Mikhail Y.

doi:10.1016/j.mce.2007.05.011

Cited by 104 publications

(71 citation statements)

References 77 publications

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“…Therefore, it is reasonable to suggest that BPA, similarly to E2, binds to ERa and produces changes in these rapid signals. Few data address the ability of BPA to mediate nongenomic estrogenic actions (see [25][26][27][28][29][30][31] and, as far we know, no information focuses on the involvement of these pathways in the proliferative effect of BPA.…”

Section: Introductionmentioning

confidence: 99%

Expression of Concern: Laccase treatment impairs bisphenol A‐induced cancer cell proliferation affecting estrogen receptor α‐dependent rapid signals

et al. 2008

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SummaryA wide variety of environmental contaminants exert estrogenic actions in wildlife, laboratory animals, and in human beings through binding to nuclear estrogen receptors (ERs). Here, the mechanism(s) of bisphenol A (BPA) to induce cell proliferation and the occurrence of its bioremediation by treatment with laccase are reported. BPA, highly present in natural world and considered as a model of environmental estrogen action complexity, promotes human cancer cell proliferation via ERa-dependent signal transduction pathways. Similar to 17b-estradiol, BPA increases the phosphorylation of both extracellular regulated kinase and AKT. Specific inhibitors of these kinase completely block the BPA effect on cancer cell proliferation. Notably, high BPA concentrations (i.e., 0.1 and 1 mM) are cytotoxic even in ERa-devoid cancer cells, indicating that an ERa-independent mechanism participates to BPA-induced cytotoxicity. On the other hand, BPA oxidation by laccase impairs the binding of this environmental estrogen to ERa loosing at all ERa-dependent effect on cancer cell proliferation. Moreover, the laccase-catalyzed oxidation of BPA reduces the BPA cytotoxic effect. Thus, laccase appears to impair BPA action(s), representing an invaluable bioremediation enzyme.2008 IUBMB IUBMB Life, 60(12): 843-852, 2008

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Section: Introductionmentioning

confidence: 99%

Expression of Concern: Laccase treatment impairs bisphenol A‐induced cancer cell proliferation affecting estrogen receptor α‐dependent rapid signals

et al. 2008

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“…Overdoses of endogenous or exogenous estrogens (De Bosschere et al 2002) may lead to various reproductive disorders, including ovarian dysfunction. Long-term exposure to high levels of estrogenic substances during maturation may result in ovarian dysfunction (hypostimulation due to the presence of ZEN in feed) (Gajęcka et al 2004, Watson et al 2007). …”

Section: Introductionmentioning

confidence: 99%

The effect of low-dose experimental zearalenone intoxication on the immunoexpression of estrogen receptors in the ovaries of pre-pubertal bitches

Gajęcka¹

2012

Polish Journal of Veterinary Sciences

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Zearalenone is an estrogenic mycotoxin that often contaminates plant material used in the production of feeds for companion animals. Small daily doses of ingested zearalenone -a competitive substrate modulating the activity of enzymes participating in estrogen biosynthesis at the pre-receptor level -can induce subclinical symptoms of hyperestrogenism in bitches. The objective of this study was to determine the effects of low zearalenone doses on the presence of estrogen receptors in the ovaries of pre-pubertal Beagle bitches. The bitches were divided into three groups of 10 animals each: experimental group I -50 μg zearalenone/kg body weight administered once daily per os; experimental group II -75 μg zearalenone/kg body weight administered once daily per os; control group -placebo containing no ZEN administered per os. The animals were ovariorectomized at the end of the experiment, at 112 days of age. Estrogen receptors were detected in ovarian specimens by immunohistochemical methods. The results revealed an absence of estrogen receptors alpha in all groups. In both experimental groups a decrease in the positive response of estrogen receptors beta in specified structures of ovaries was observed. Very low α-zearalenol levels probably attested to the slowing down (hypostimulation) of the biotransformation process. Overall, zearalenone intoxication led to hyperestrogenism during a specific developmental stage of pre-pubertal bitches. As regards hormesis, the threshold dose of zearalenone (adaptive capability) was exceeded in the ovaries of experimental group II animals. The results obtained in both experimental groups suggest that long-term exposure to low-dose zearalenone intoxication decreased the degree of estrogen receptors beta staining in particular structures of ovaries in the experimental bitches, which initiated epigenetic modification mechanisms that inhibited ovarian development.

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“…Furthermore, BPA rapidly initiates complex set of signaling which could not be explained by its binding to estrogen receptors and it exerts many of these effects at low doses even lower than the current "safe" exposure limit for humans (Krishnan et al, 1993;Takeshita et al, 2001;Quesada et al, 2002). Current research is focused on understanding the full spectrum and the mechanisms of BPA endocrine disrupting actions (Watson et al, 2007a;2007b).…”

Section: Bisphenol a (Bpa)mentioning

confidence: 99%

Endocrine Disruptors and Breast Cancer Risk - Time to Consider the Environment

Abdel‐Rahman

Moustafa²,

Ahmed³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissues

Cited by 104 publications

References 77 publications

Expression of Concern: Laccase treatment impairs bisphenol A‐induced cancer cell proliferation affecting estrogen receptor α‐dependent rapid signals

Expression of Concern: Laccase treatment impairs bisphenol A‐induced cancer cell proliferation affecting estrogen receptor α‐dependent rapid signals

The effect of low-dose experimental zearalenone intoxication on the immunoexpression of estrogen receptors in the ovaries of pre-pubertal bitches

Endocrine Disruptors and Breast Cancer Risk - Time to Consider the Environment

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