Endocrine Disruptors and Breast Cancer Risk - Time to Consider the Environment

Abdel‐Rahman, Wael M.; Moustafa, Yasser M.; Ahmed, Bassamat Omar; Mostafa, Randa

doi:10.7314/apjcp.2012.13.12.5937

Cited by 14 publications

(12 citation statements)

References 107 publications

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“…BPA is classified as an Endocrine Disrupting Chemical (EDC) because it can act as a xenoestrogen. EDCs interfere and prevent the binding of natural hormones to their receptors and/or can act as a hormone mimics; consequently, they exaggerate the effects of endogenous hormones [2,8]. Researchers have also found that exposure to BPA is associated with an increased risk of insulin resistance, type 2 diabetes, and alteration of normal immune response resulting in high levels of Immunoglobulin E (IgE) and interleukin-4 potentially leading to allergies such as hay fever.…”

Section: Introductionmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Hafezi

Abdel‐Rahman

2019

CMP

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Background: Bisphenol A (BPA) is a synthetic plasticizer that is commonly used in the production of polycarbonate plastics and epoxy resins. Human exposure occurs when BPA migrates from food and beverage containers into the contents when heated or even under normal conditions of use. BPA exerts endocrine disruptor action due to its weak binding affinity for the estrogen receptors ERα and ERβ. BPA exerts other effects by activating the membrane receptor GPER (GPR30) and/or other receptors such as the estrogen-related receptors (ERRs). Objective: This review summarizes emerging data on BPA and cancer. These include data linking exposure to BPA with an increased risk of hormone-related cancers such as those of the ovary, breast, prostate, and even colon cancer. BPA can also induce resistance to various chemotherapeutics such as doxorubicin, cisplatin, and vinblastine in vitro. The development of chemoresistance to available therapeutics is an emerging significant aspect of BPA toxicity because it worsens the prognosis of many tumors. Conclusion: Recent findings support a causal role of BPA at low levels in the development of cancers and in dictating their response to cytotoxic therapy. Accurate knowledge and consideration of these issues would be highly beneficial to cancer prevention and management.

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Section: Introductionmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Hafezi

Abdel‐Rahman

2019

CMP

Self Cite

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“…Notably, EDCs are classes of molecules when exposed to our body, they interact with various hormone receptors at very low concentrations and alter the hormone signaling pathways affecting various hormonally regulated processes including reproduction and development (Richter et al, 2007). Chronic and/or acute exposure to EDCs results in harmful health effects including birth defects, diabetes, cancers, reproductive problems, early puberty, and obesity (Fernandez and Russo, 2010; Abdel-Rahman et al, 2012; Fucic et al, 2012; Singh and Li, 2012; Sengupta et al, 2013). Exposure to EDCs results in alteration in the gene expression profiles.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, endocrine disruptors are a class of compounds that alters the functioning of the endocrine system and leads to adverse health effects and is a major health concern (Schonfelder et al, 2002a; Fernandez and Russo, 2010; Abdel-Rahman et al, 2012; Fucic et al, 2012; Singh and Li, 2012; Sengupta et al, 2013). In the present study, we analyzed the impact of a well-known estrogenic EDC, bisphenol-A (BPA) (and also estradiol (E2)) in transcriptional regulation of HOXB9 gene in vitro and in vivo .…”

Section: Introductionmentioning

confidence: 99%

Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo

Deb

Bhan

Hussain

et al. 2016

Gene

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HOXB9 is a homeobox-containing gene that plays a key role in mammary gland development and is associated with breast and other types of cancer. Here, we demonstrate that HOXB9 expression is transcriptionally regulated by estradiol (E2), in vitro and in vivo. We also demonstrate that the endocrine disrupting chemical bisphenol-A (BPA) induces HOXB9 expression in cultured human breast cancer cells (MCF7) as well as in vivo in the mammary glands of ovariectomized (OVX) rats. Luciferase assay showed that estrogen-response-elements (EREs) in the HOXB9 promoter are required for BPA-induced expression. Estrogen-receptors (ERs) and ER-co-regulators such as MLL-histone methylase (MLL3), histone acetylases, CBP/P300, bind to the HOXB9 promoter EREs in the presence of BPA, modify chromatin (histone methylation and acetylation) and lead to gene activation. In summary, our results demonstrate that BPA exposure, like estradiol, increases HOXB9 expression in breast cells both in vitro and in vivo through a mechanism that involves increased recruitment of transcription and chromatin modification factors.

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“…It has been proposed that exposure to xenoestrogens led to the increased prevalence of breast cancer (Abdel-Rahman et al, 2012;Kerdivel et al, 2013). TCDD, as a kind of EDC, has multiple endocrine activities and has been known to increase the incidence of breast cancer in regions contaminated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) (Warner et al, 2002).…”

Section: Research Articlementioning

confidence: 99%

Tumorigenic Effects of Endocrine-Disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

Chu¹,

Cruz²,

Hwang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Endocrine Disruptors and Breast Cancer Risk - Time to Consider the Environment

Cited by 14 publications

References 107 publications

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy

Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo

Tumorigenic Effects of Endocrine-Disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

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