Nongenital cancers metastatic to the ovary

Petru, Edgar; Pickel, H.; Heydarfadai, M.; Lahousen, M; Haas, J.; Schaider, Helmut; Tamussino, Karl

doi:10.1016/0020-7292(92)90803-q

Cited by 31 publications

(54 citation statements)

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“…The prognosis of patients with MOTs from non-genital tract origin tumors is very poor (Lee et al 2009); 5-year survival rates are 5.4-12.1 % (Jiang et al 2009;Petru et al 1992;Webb et al 1975). Metastasis to the ovaries is commonly associated with metastasis to other sites (Megibow et al 1985).…”

Section: Discussionmentioning

confidence: 96%

“…MOTs are occasionally diagnosed prior to detection of the primary cancer (Kim et al 1996;Petru et al 1992). In this study, six patients underwent PET/CT for evaluation of an ovarian mass without a history of known primary malignancy, and 12 patients were diagnosed with MOTs simultaneously with the primary malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…Some patients, however, visit the hospital with incidentally found ovarian masses (Kim et al 1996;Lee et al 2009;Petru et al 1992). Compared with the prognosis of primary ovarian tumors, that of MOTs is extremely poor (Jiang et al 2009).…”

Section: Introductionmentioning

confidence: 97%

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F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

Park

Yoo

et al. 2015

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

Park

Yoo

et al. 2015

J Cancer Res Clin Oncol

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“…All patients aged in their sixties had severe peritoneal dissemination consistent with ovarian metastases. Curative resection and residual tumor volume would be the most important prognostic parameters, 11,21 as shown in the current study.…”

Section: Discussionmentioning

confidence: 95%

“…4 The majority of metastatic gastric carcinomas to the ovaries are Krukenberg tumors, whereas metastatic ovarian tumors often do not fulfil the criteria of Krukenberg tumors. 5,8,10,11 Gastric cancer, the most common malignancy in Japan, frequently reveals lymph node, peritoneum, and liver metastases. 12 In contrast, ovarian metastasis is rare.…”

Section: Introductionmentioning

confidence: 99%

Clinical and pathological study of gastric cancer with ovarian metastasis

Kobayashi

Sugiyama

Cho

et al. 2003

International Journal of Clinical Oncology

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Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

Crobach

Ruano

Eijk

et al. 2016

The Journal of Pathology CR

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The mutational profiles of primary colorectal cancers (CRCs) and corresponding ovarian metastases were compared. Using a custom‐made next generation sequencing panel, 115 cancer‐driving genes were analyzed in a cohort of 26 primary CRCs and 30 matching ovarian metastases (four with bilateral metastases). To obtain a complete overview of the mutational profile, low thresholds were used in bioinformatics analysis to prevent low frequency passenger mutations from being filtered out. A subset of variants was validated using Sanger and/or hydrolysis probe assays. The mutational landscape of CRC that metastasized to the ovary was not strikingly different from CRC in consecutive series. When comparing primary CRCs and their matching ovarian metastases, there was considerable overlap in the mutations of early affected genes. A subset of mutations demonstrated less overlap, presumably being passenger mutations. In particular, primary CRCs showed a substantially high number of passenger mutations. We also compared the primary CRCs and matching metastases for stratifying variants of six genes (KRAS, NRAS, BRAF, FBXW7, PTEN and PIK3CA) that select for established (EGFR directed) or future targeted therapies. In a total of 31 variants 12 were not found in either of the two locations. Tumours thus differed in the number of discordant variants between the primary tumours and matching metastases. Half of these discordant variants were definitive class 4/5 pathogenic variants. However, in terms of temporal heterogeneity, no clear relationship was observed between the number of discordant variants and the time interval between primary CRCs and the detection of ovarian metastases. This suggests that dormant metastases may be present from the early days of the primary tumours.

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Nongenital cancers metastatic to the ovary

Cited by 31 publications

References 0 publications

F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

F-18 FDG PET/CT findings of metastatic ovarian tumors from gastrointestinal tract origin

Clinical and pathological study of gastric cancer with ovarian metastasis

Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations

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