Clinical and pathological study of gastric cancer with ovarian metastasis

Kobayashi, Osamu; Sugiyama, Yuka; Cho, Haruhiko; Tsuburaya, Akira; Sairenji, Motonori; Motohashi, Hisahiko; Yoshikawa, Takaki

doi:10.1007/s101470300012

Cited by 28 publications

(19 citation statements)

References 14 publications

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“…There was no disagreement regarding eligibility of full-text articles (Cohen's kappa = 1). Finally, a total of 13 articles dated between 2002 and 2017 fulfilled the selection criteria and were therefore included in this systematic review [7,8,26,27,28,29,30,31,32,33,34,35,36]; this pool of articles consisted of 13 retrospective reports. Characteristics of the included studies are summarized in table 1.…”

Section: Resultsmentioning

confidence: 99%

Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review

Aurello¹,

Berardi²,

Antolino³

et al. 2018

Oncol Res Treat

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Background: The treatment of metachronous Krukenberg tumor (mKT) from gastric cancer remains unexplored. We performed a literature review to evaluate whether or not surgical treatment improves survival. Methods: A systematic review according to PRISMA guidelines was performed. Studies reporting on patients who underwent surgical treatment for mKT from gastric cancer were selected. Metachronous disease was divided as follows: confined to the ovaries, confined to the pelvis, or beyond the pelvis. Outcomes evaluated included overall survival (OS), progression-free survival (PFS), resection rate (R0), and factors predicting survival. Results: 13 retrospective reports fulfilled the selection criteria (512 patients). Most of the patients presented at a premenopausal age. The median presentation interval from gastrectomy ranged from 16 to 21.4 months. Median OS ranged between 9 and 36 months. 1-year OS ranged between 52.5 and 59%, and 3-years OS between 9.8 and 36.5%. Resection margin, peritoneal seeding, and chemotherapy regimen and cycles influenced survival. Conclusion: Surgical treatment and adjuvant chemotherapy in patients with mKT from gastric cancer seems to be associated with improved survival and is justified especially in young patients. Disease location and R0 resection should be considered when selecting patients.

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Section: Resultsmentioning

confidence: 99%

Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review

Aurello¹,

Berardi²,

Antolino³

et al. 2018

Oncol Res Treat

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“…Furthermore, it has also been reported that ovarian metastases from gastric cancer are more commonly found in premenopausal rather than in postmenopausal women (17,19,22,23). Miller et al (24) hypothesized that the higher blood flow in premenopausal ovaries may increase the risk of metastasis to the ovary.…”

Section: Characteristicsmentioning

confidence: 99%

“…However, the number of related studies is limited, and some studies have reported conflicting results. Kobayashi et al (22) reported that the median survival following detection of the ovarian tumor was significantly longer in patients who underwent curative resection compared with those who received noncurative resection (30.4 vs. 10.3 months, respectively). Cheong et al (19) reported that complete resection of gross metastases from gastric cancer significantly improved the overall survival (18 vs. 9 months) and the progression-free survival (8 vs. 5 months).…”

Section: Management and Prognosismentioning

confidence: 99%

Metastatic gastric cancer to the female genital tract

Matsushita

Watanabe

Wakatsuki

2016

Molecular and Clinical Oncology

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Abstract. Metastases to the female genital tract from gastric cancer are rare, but they significantly worsen the prognosis of such patients. The potential routes for metastasis to the female genital tract from gastric cancer include hematogenous spread, lymphatic spread and surface implantation. The rate of lymphatic metastasis to the ovary from gastric cancer has been reported to be higher compared with that from colorectal cancer. Uterine or Fallopian tube metastases are usually secondary to ovarian metastases, which are typically identified prior to the detection of gastric cancer in half of all synchronous cases, with complaints of abdominal distention, pain, palpable mass, or abnormal uterine bleeding. The prognosis of patients with female genital tract metastases from gastric cancer is extremely poor, and is worse compared with that of other primary sites, such as the breast and colorectum. In the past, surgical intervention in such patients consisted mainly of palliative resection to relieve the symptoms associated with a sizeable pelvic mass. However, recent retrospective studies based on a relatively small number of patients have reported that surgical tumor debulking plus chemotherapy may improve the prognosis of patients with metastatic ovarian cancer originating from gastric cancer.

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“…In a recent study, 24 ovarian metastases were detected in 897 female patients with gastric cancer. 7 Our patient had an enlarged right ovarium and abundant ascites; however, the biopsy of the ovarium was not carried out to confirm the metastasis. Breast may also be a site for metastases from many extramammarian neoplasms including gastric signet-ring cell Ca.…”

Section: Discussionmentioning

confidence: 94%

Gastric Signet-Ring Cell Adenocarcinoma Presenting With Left Arm Deep-Vein Thrombosis and Bilateral Chylothorax

Kayacan

Karnak

Can

et al. 2007

Clin Appl Thromb Hemost

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A 28-year-old housewife, a life-long nonsmoker, presented with 3 weeks of pleuritic chest pain along with swollen right leg, left arm, and left breast. Six months previously she had left subclavian vein thrombosis. On admission, bilateral supraclavicular lymphedema on right leg and left arm and breast was observed and bilateral pleural fluid, chylous exudates, was detected. Abdomen computed tomography revealed abundant ascites and right ovarian enlargement. Whole body bone scintigraphy showed bone metastases on left humerus, right femur, and pelvis. Bronchial biopsy, obtained from edematous, hyperemic-irregular mucosa, revealed a carcinoma composed of signet-ring cells with intracytoplasmic mucin. Breast biopsy also showed signet-ring cells within the lymphatics. Pleural fluid cytology showed similar malignant cells. The patient was diagnosed as gastric signet-ring cell adenocarcinoma with endobronchial, mammary, ovarian, pleural, pericardial, peritoneal, and osteal metastases. The authors recommend that deep-vein thrombosis in unusual sites deserves further evaluation for an occult malignancy.

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Clinical and pathological study of gastric cancer with ovarian metastasis

Abstract: The prognosis for ovarian metastasis of gastric cancer was poor without curative resection. Because of frequent microscopic metastases to the uterus, total hysterectomy with bilateral oophorectomy is recommended if curative resection is possible.

Cited by 28 publications

References 14 publications

Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review

Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review

Metastatic gastric cancer to the female genital tract

Gastric Signet-Ring Cell Adenocarcinoma Presenting With Left Arm Deep-Vein Thrombosis and Bilateral Chylothorax

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