Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial

Abstract

BackgroundElevated android body fat increases the risk of developing cardiometabolic diseases. Postprandial hyperglycemia contributes to the proatherogenic metabolic state evident in android adiposity. Due to the insulinotropic effect of milk‐derived proteins, postprandial hyperglycemia has been shown to be reduced with the addition of dairy products. The purpose of this study was to determine whether one serving of nonfat milk added to an oral glucose tolerance test (OGTT) could attenuate postprandial hyperglycemia in individuals with elevated android adiposity and whether these improvements would be associated with metabolic and/or peripheral hemodynamic effects.MethodsIn this placebo‐controlled, randomized, crossover experimental study, 29 overweight/obese adults (26 ± 1 year) consumed an OGTT beverage (75 g glucose) combined with either nonfat milk (227 g) or a placebo control (12 g lactose + 8 g protein + 207 g water) that was matched for both carbohydrate and protein quantities.ResultsIn the whole sample, blood glucose and insulin concentrations increased over time in both trials with no significant differences between trials. Relative increases in peak blood glucose response were significantly related to android body fat (p < 0.05). The subjects in the highest tertiles of android body fat displayed attenuated hyperglycemic responses as well as improvements in flow‐mediated dilation (FMD) after milk intake.ConclusionsA single serving of nonfat milk may attenuate acute hyperglycemia in individuals with elevated android body fat offering a simple and convenient option for managing elevations in blood glucose.

The intestinal mycobiota and its relationship with overweight, obesity and nutritional aspects

“…lambica presented a high positive correlation with the waist–hip ratio, which is a parameter related to android central obesity (defined as central or abdominal obesity with excess distribution of body fat in the abdomen). This type of obesity is characterized by several health risks, such as hypertension, cardiometabolic diseases and insulin resistance 54 . Fraberger et al 55 .…”

Role of Fluid Milk in Attenuating Postprandial Hyperglycemia and Hypertriglyceridemia

“…A recent controlled, randomized clinical trial made an attempt to discern the role of milk protein in regulating postprandial hyperglycemia [ 140 ]. In individuals with the highest android obesity, non-fat milk attenuated acute hyperglycemia compared with a placebo drink matched for macronutrient and caloric content.…”

“…In individuals with the highest android obesity, non-fat milk attenuated acute hyperglycemia compared with a placebo drink matched for macronutrient and caloric content. Any differences in postprandial hyperglycemia between trials could not be attributed to the macronutrients, and specifically the protein quantity, of milk [ 140 ]. Additionally, the beneficial effects of dairy intake were associated with the elevated endothelium-dependent vasodilation [ 140 ].…”

“…Any differences in postprandial hyperglycemia between trials could not be attributed to the macronutrients, and specifically the protein quantity, of milk [ 140 ]. Additionally, the beneficial effects of dairy intake were associated with the elevated endothelium-dependent vasodilation [ 140 ]. These findings suggest that milk consumed with a high-carbohydrate meal may reduce hyperglycemic responses preferentially in pre-clinical individuals with less favorable cardiometabolic profiles and that these metabolic effects may be related to hemodynamic improvements.…”