Nonenzymatic electrochemical sensor based on metal oxide, MO (M= Cu, Ni, Zn, and Fe) nanomaterials for neurotransmitters: An abridged review

Ratnam, K. Venkata; Manjunatha, H.; Janardan, Sannapaneni; Naidu, K. Chandra Babu; Ramesh, S.

doi:10.1016/j.sintl.2020.100047

Cited by 32 publications

(17 citation statements)

References 153 publications

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“…As already outlined, the precise quantification of glucose and DA is crucial both for analytical applications and in diagnostic research, since they are key in physiology and above all are coupled with important diseases such as diabetes mellitus, Parkinson’s disease and schizophrenia [ 143 , 144 ]. It is well known that the amount of DA, being a fundamental catecholamine neurotransmitter in the mammalian central nervous system, affects the body physiological functions [ 145 ], and it is also correlated with brain glucose metabolism that, in neuronal activity, triggers the transients of vesicular neurotransmitter release and fluctuations of metabolites in the proximity of the activated neurons [ 146 ].…”

Section: An Overview On Mox Nanomaterials Used For Biosensing Detementioning

confidence: 99%

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

Fazio

Spadaro

Corsaro

et al. 2021

Sensors

110

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Pure, mixed and doped metal oxides (MOX) have attracted great interest for the development of electrical and electrochemical sensors since they are cheaper, faster, easier to operate and capable of online analysis and real-time identification. This review focuses on highly sensitive chemoresistive type sensors based on doped-SnO2, RhO, ZnO-Ca, Smx-CoFe2−xO4 semiconductors used to detect toxic gases (H2, CO, NO2) and volatile organic compounds (VOCs) (e.g., acetone, ethanol) in monitoring of gaseous markers in the breath of patients with specific pathologies and for environmental pollution control. Interesting results about the monitoring of biochemical substances as dopamine, epinephrine, serotonin and glucose have been also reported using electrochemical sensors based on hybrid MOX nanocomposite modified glassy carbon and screen-printed carbon electrodes. The fundamental sensing mechanisms and commercial limitations of the MOX-based electrical and electrochemical sensors are discussed providing research directions to bridge the existing gap between new sensing concepts and real-world analytical applications.

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Section: An Overview On Mox Nanomaterials Used For Biosensing Detementioning

confidence: 99%

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

Fazio

Spadaro

Corsaro

et al. 2021

Sensors

110

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show abstract

“…The concentrations were detected by the same DPV technique with start and stop potentials of 0 and 0.4, respectively, in a modulation time of 0.05 s. In addition, between each measurement, the desorption solution, which contains methanol:acetic acid in the appropriate amount of (9:1) v/v solution, was used to desorb the DA molecule from For the analytical behaviour study, a linear correlation was observed between the DPV response current and the DA concentration used, ranging from 0.395 nM-3.96 nM. The detection limit was achieved as 0.193 nM (Table 1), which is better than other reported studies [31]. These results show that the N-methacryloyl-(L)-phenylalanine monomer can enhance electrode selectivity for DA molecules.…”

Section: Dpv Response Of the Mip Pge Sensor For Different Da Concentr...mentioning

confidence: 78%

Gold-Modified Molecularly Imprinted N-Methacryloyl-(l)-phenylalanine-containing Electrodes for Electrochemical Detection of Dopamine

et al. 2022

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A molecularly imprinted polymer-based pencil graphite electrode (MIP PGE) sensor, modified with gold nanoparticles, was utilized for the detection of dopamine in the presence of other biochemical compounds using cyclic voltammetry (CV) and differential pulse voltammetry (DPV), depending on its strong electroactivity function. The pulse voltammetry methods recorded the highest response. In addition to the high oxidation rate of DA and the other biomolecule interferences available in the sample matrix used, which cause overlapping voltammograms, we aimed to differentiate them in a highly sensitive limit of detection range. The calibration curves for DA were obtained using the CV and DPV over the concentration range of 0.395–3.96 nM in 0.1 M phosphate buffer solution (PBS) at pH 7.4 with a correlation coefficient of 0.996 and a detection limit of 0.193 nM. The electrochemical technique was employed to detect DA molecules quantitatively in human blood plasma selected as real samples without applying any pre-treatment processes. MIP electrodes proved their ability to detect DA with high selectivity, even with epinephrine and norepinephrine competitor molecules and interferences, such as ascorbic acid (AA). The high level of recognition achieved by molecularly imprinted polymers (MIPs) is essential for many biological and pharmaceutical studies.

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“…Carbon-based nanostructured materials, such as carbon nanotubes, graphene, carbon quantum dots, fullerenes, etc. [ 59 ], metal nanoparticles such as AuNPs, silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) [ 60 ], metal oxides such as oxides of copper, nickel, zinc, and iron [ 61 ], MIPs [ 39 ], or conductive polymers [ 62 ] have been applied in preparing electrochemical biosensors. The resulted remarkable electrochemical properties are usually due to the synergies between the basic electrode material and the applied modifiers.…”

Section: Electrochemical Peptide-based Sensors For Foodborne Pathogenmentioning

confidence: 99%

Electrochemical Peptide-Based Sensors for Foodborne Pathogens Detection

et al. 2021

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Food safety and quality control pose serious issues to food industry and public health domains, in general, with direct effects on consumers. Any physical, chemical, or biological unexpected or unidentified food constituent may exhibit harmful effects on people and animals from mild to severe reactions. According to the World Health Organization (WHO), unsafe foodstuffs are especially dangerous for infants, young children, elderly, and chronic patients. It is imperative to continuously develop new technologies to detect foodborne pathogens and contaminants in order to aid the strengthening of healthcare and economic systems. In recent years, peptide-based sensors gained much attention in the field of food research as an alternative to immuno-, apta-, or DNA-based sensors. This review presents an overview of the electrochemical biosensors using peptides as molecular bio-recognition elements published mainly in the last decade, highlighting their possible application for rapid, non-destructive, and in situ analysis of food samples. Comparison with peptide-based optical and piezoelectrical sensors in terms of analytical performance is presented. Methods of foodstuffs pretreatment are also discussed.

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Nonenzymatic electrochemical sensor based on metal oxide, MO (M= Cu, Ni, Zn, and Fe) nanomaterials for neurotransmitters: An abridged review

Cited by 32 publications

References 153 publications

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

Gold-Modified Molecularly Imprinted N-Methacryloyl-(l)-phenylalanine-containing Electrodes for Electrochemical Detection of Dopamine

Electrochemical Peptide-Based Sensors for Foodborne Pathogens Detection

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