“…It is usually prescribed for the treatment of psychotic symptoms such as schizophrenia, Parkinson's disease and schizoaffective psychoses in order to decrease restlessness, aggressiveness and impulsive behavior in psychotic patients. 3,4 PPZ is extensively metabolized in the liver to a number of metabolites by sulfoxidation, hydroxylation, dealkylation and glucuronidation. 5,6 Therefore, the determination of PPZ is important in medical screening, clinical diagnostics, and in the pharmaceutical industry to obtain the optimum therapeutic dosage in bodily uids to minimize the risk of toxicity.…”