Nonconvulsive status epilepticus: the role of morphine and its antagonist

Drug-induced status epilepticus

“…More convincingly, SE has been reasonably attributed to opiates, specifically morphine and tramadol, either in conjunction with other proconvulsant agents or in overdose [54,55], and there are two wellcharacterized reports of SE following thyroxine overdose, one being in the context of overenthusiastic correction of myxedema coma [56]. There are also several well-described cases of SE following overdose of antihistamines such as dramamine and diphenhydramine, with a clinical picture similar to that of antidepressant overdoses [57], reflecting additional anticholinergic/serotonergic effects.…”

Methadone and Fluconazole

“…It has been postulated that administering an opioid antagonist to patients receiving long-term opioid therapy, especially if they are experiencing opioid-related neurotoxicity, such as myoclonus, may precipitate seizures. 33,34 Naloxone may inhibit the anticonvulsant effect of the opioid. 34 This case also illustrates how oral candidiasis can significantly impact a patient's quality of life.…”

Non-convulsive status epilepticus in adults - an overview

“…8a and 8b) (or naloxone in the case of opiate-overdose [ fig. 8c]) [92,93]. Thus, the response of this EEG pattern to benzodiazepines does not help to distinguish TPW from ictal spikewave activity.…”