Noncontact photoacoustic imaging based on optical quadrature detection with a multiport interferometer

Park, Soongho; Rim, Seog-Hoon; Kim, Younggue; Lee, Byeong Ha

doi:10.1364/ol.44.002590

Cited by 20 publications

(21 citation statements)

References 22 publications

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“…3×3 fiber-optic couplers have been widely used for extraction of the phase information of various interferometric systems [32,43]. Huang et al reported a similar method to obtain phase information using three optical signals having phase shifts of 2π/3 [37].…”

Section: Resultsmentioning

confidence: 99%

“…Park et al used two channels of a 3×3 fiber coupler to measure the phase change of the probe light caused by the sample surface vibration [32], while the present method measures the intensity change of the probe light caused by the initial photoacoustic pressure. Both methods eliminate the need of the phase stability process.…”

Section: Resultsmentioning

confidence: 99%

“…In Ref. [32], a low-coherence source was used to eliminate the influence of the complex interference caused by the probe light backscattered from the subsurface of a scattering sample. However, the interferometric sensitivity is dependent on the optical path difference between the reference and probe beams.…”

Section: Resultsmentioning

confidence: 99%

“…This will slow down the imaging speed. Park et al demonstrated noncontact photoacoustic imaging of hair phantoms based on optical quadrature detection [32]. They used the two channels of a 3×3 fiber coupler to measure the sample surface vibration.…”

Section: Introductionmentioning

confidence: 99%

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Complete-noncontact photoacoustic microscopy by detection of initial pressures using a 3×3 coupler-based fiber-optic interferometer

Wang¹,

Hu²,

Peng³

et al. 2019

Biomed. Opt. Express

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We demonstrate a 3×3 coupler-based fiber-optic interferometric system to detect the local initial photoacoustic pressure. In contrast with the existing interferometric photoacoustic microscopy (PAM) relying on the measurement of the phase change of the probe light caused by the sample surface vibration, the present method measures the intensity change of the probe light caused by the initial photoacoustic pressure. Compared with the conventional interferometric PAMs, this method has the advantages: (1) it is free from the influence of the rough tissue surface, achieving complete noncontact in vivo imaging; (2) the probe light and the excitation light are focused at a same point below the sample surface, and the confocal configuration makes it more convenient for in vivo imaging; and (3) there is no need for phase stabilization, allowing a high imaging speed. These advantages show that the method will be a promising technique for in vivo imaging. This method is verified by imaging of a resolution test target and in vivo imaging of the blood vessels in a mouse ear.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Complete-noncontact photoacoustic microscopy by detection of initial pressures using a 3×3 coupler-based fiber-optic interferometer

Wang¹,

Hu²,

Peng³

et al. 2019

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Although these sensors are highly sensitive, they are also sensitive to the unwanted environmental noise, which greatly limits their applications in practical settings. Recently, a fiber interferometer based on a 3 × 3 optical coupler with optical quadrature detection has been proposed to detect nanometer-scale displacement without being affected by the environmental variation [ 142 ]. Further investigations are needed for in vivo biological imaging.…”

Section: All-optical Detection Reflection-mode Photoacoustic Micromentioning

confidence: 99%

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Tsang

Wong

2020

Sensors

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Optical-based sensing approaches have long been an indispensable way to detect molecules in biological tissues for various biomedical research and applications. The advancement in optical microscopy is one of the main drivers for discoveries and innovations in both life science and biomedical imaging. However, the shallow imaging depth due to the use of ballistic photons fundamentally limits optical imaging approaches’ translational potential to a clinical setting. Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast. PAT uniquely enjoys high-resolution deep-tissue imaging owing to the utilization of diffused photons. The exploration of endogenous contrast agents and the development of exogenous contrast agents further improve the molecular specificity for PAT. PAT’s versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications. In this review, representative endogenous and exogenous PA contrast agents will be introduced alongside common PAT system configurations, including the latest advances of all-optical acoustic sensing techniques.

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Towards non-contact photoacoustic imaging [review]

Hosseinaee

Bell

et al. 2020

Photoacoustics

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Photoacoustic imaging (PAI) takes advantage of both optical and ultrasound imaging properties to visualize optical absorption with high resolution and contrast. Photoacoustic microscopy (PAM) is usually categorized with all-optical microscopy techniques such as optical coherence tomography or confocal microscopes. Despite offering high sensitivity, novel imaging contrast, and high resolution, PAM is not generally an all-optical imaging method unlike the other microscopy techniques. One of the significant limitations of photoacoustic microscopes arises from their need to be in physical contact with the sample through a coupling media. This physical contact, coupling, or immersion of the sample is undesirable or impractical for many clinical and pre-clinical applications. This also limits the flexibility of photoacoustic techniques to be integrated with other all-optical imaging microscopes for providing complementary imaging contrast. To overcome these limitations, several non-contact photoacoustic signal detection approaches have been proposed. This paper presents a brief overview of current non-contact photoacoustic detection techniques with an emphasis on all-optical detection methods and their associated physical mechanisms.

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Noncontact photoacoustic imaging based on optical quadrature detection with a multiport interferometer

Cited by 20 publications

References 22 publications

Complete-noncontact photoacoustic microscopy by detection of initial pressures using a 3×3 coupler-based fiber-optic interferometer

Complete-noncontact photoacoustic microscopy by detection of initial pressures using a 3×3 coupler-based fiber-optic interferometer

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Towards non-contact photoacoustic imaging [review]

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