Noncoding RNAs in cancer ferroptosis: From biology to clinical opportunity

Shan, Chan; Liang, Yan; Wang, Kun; Li, Peifeng

doi:10.1016/j.biopha.2023.115053

Cited by 4 publications

(2 citation statements)

References 256 publications

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“…Finally, it is interesting to note that the ferroptosis pathway is largely represented. This type of cell death is increasingly studied in the context of cancer [ 245 ] in line with non-coding RNAs [ 246 ], as well as recently—in particular—in the ER−/AR+ BC subtype [ 247 ].…”

Section: Mirna Implications In Breast Cancermentioning

confidence: 99%

ER Negative Breast Cancer and miRNA: There Is More to Decipher Than What the Pathologist Can See!

Chamandi,

El-Hajjar,

El Kurdi

et al. 2023

Biomedicines

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Breast cancer (BC), the most prevalent cancer in women, is a heterogenous disease. Despite advancements in BC diagnosis, prognosis, and therapeutics, survival rates have drastically decreased in the metastatic setting. Therefore, BC still remains a medical challenge. The evolution of high-throughput technology has highlighted gaps in the classification system of BCs. Of particular interest is the notorious triple negative BC, which was recounted as being heterogenous itself and it overlaps with distinct subtypes, namely molecular apocrine (MA) and luminal androgen (LAR) BCs. These subtypes are, even today, still misdiagnosed and poorly treated. As such, researchers and clinicians have been looking for ways through which to refine BC classification in order to properly understand the initiation, development, progression, and the responses to the treatment of BCs. One tool is biomarkers and, specifically, microRNA (miRNA), which are highly reported as associated with BC carcinogenesis. In this review, the diverse roles of miRNA in estrogen receptor negative (ER−) and androgen receptor positive (AR+) BC are depicted. While highlighting their oncogenic and tumor suppressor functions in tumor progression, we will discuss their diagnostic, prognostic, and predictive biomarker potentials, as well as their drug sensitivity/resistance activity. The association of several miRNAs in the KEGG-reported pathways that are related to ER-BC carcinogenesis is presented. The identification and verification of accurate miRNA panels is a cornerstone for tackling BC classification setbacks, as is also the deciphering of the carcinogenesis regulators of ER − AR + BC.

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Section: Mirna Implications In Breast Cancermentioning

confidence: 99%

ER Negative Breast Cancer and miRNA: There Is More to Decipher Than What the Pathologist Can See!

Chamandi,

El-Hajjar,

El Kurdi

et al. 2023

Biomedicines

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“…Unlike apoptosis, necrosis, and autophagy, ferroptosis is driven by iron-dependent lipid peroxidation. The disruption of iron and lipid metabolism induces reactive oxygen species (ROS) production and accumulation, leading to mitochondrial damage, membrane integrity breakdown, and ultimately cell death [ 16 ]. Alterations in the ferroptosis regulatory network can lead to the development of various diseases including cancer.…”

Section: Introductionmentioning

confidence: 99%

csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis

Wen,

Yin,

Wang

et al. 2023

Parasites Vectors

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Background Clonorchis sinensis (CS) is classified as a group 1 carcinogen and can cause intrahepatic cholangiocarcinoma (ICC). CS extracellular vesicles (CsEVs) play important roles in mediating communication between parasitic helminths and humans. Ferroptosis is a novel cell death mechanism that is mainly induced by lipid peroxidation and iron overload. However, the role of CsEVs in the regulation of ferroptosis in ICC remains unclear. This study aimed to explore the role of CS-secreted miR-96-5p (csi-miR-96-5p) delivered by CsEVs in ICC progression and ferroptosis. Methods Tissue samples were collected from ICC patients with CS infection (CS-ICC) or without CS infection (NC-ICC). The levels of csi-miR-96-5p and PTEN gene were determined by quantitative polymerase chain reaction (qPCR) and western blotting, and survival analysis was performed. CsEVs were isolated and identified by ultracentrifugation and transmission electron microscopy. Lentiviruses were used to establish stable cell lines with csi-miR-96-5p mimic expression, PTEN overexpression (PTEN-EXO) and PTEN CRISPR/Cas9-based knockout (PTEN-KO) and their respective negative controls. Cell proliferation was assessed by performing Cell Counting Kit-8 assays in vitro and in a tumor xenograft model in vivo, and cell migration was assessed by performing Transwell assays. Erastin is used to induce ferroptosis. Ferroptosis levels were evaluated using biomarkers. Results High csi-miR-96-5p and low PTEN expression was observed in CS-ICC tissues and was associated with poor overall survival. csi-miR-96-5p was highly enriched in CsEVs and was taken up by ICC cells. csi-miR-96-5p mimics or PTEN-KO significantly promoted the growth and migration of ICC cells in vitro and in vivo, whereas PTEN-EXO exerted the opposite effect. Mechanistically, csi-miR-96-5p mimics or PTEN-KO inhibited erastin-induced ferroptosis, including reducing the accumulation of Fe2+, lipid reactive oxygen species, and malondialdehyde, increasing the GSH/GSSG ratio and levels of SLC7A11 and GPX4, whereas PTEN-EXOs exerted the opposite effect. Conclusions csi-miR-96-5p delivered by CsEVs reduced ferroptosis by regulating the expression of the PTEN/SLC7A11/GPX4 axis, thereby promoting ICC proliferation and migration. For the first time to our knowledge, we found that CS miRNAs could promote tumor development through ferroptosis. Graphical Abstract

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Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?

Kciuk,

Gielecińska,

Kałuzińska-Kołat

et al. 2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Noncoding RNAs in cancer ferroptosis: From biology to clinical opportunity

Cited by 4 publications

References 256 publications

ER Negative Breast Cancer and miRNA: There Is More to Decipher Than What the Pathologist Can See!

ER Negative Breast Cancer and miRNA: There Is More to Decipher Than What the Pathologist Can See!

csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis

Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?

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