Noncoding RNA-mediated macrophage and cancer cell crosstalk in hepatocellular carcinoma

Zhou, Zhixia; Wang, Zhan; Gao, Jie; Lin, Zhijuan; Wang, Yin; Shan, Peipei; Li, Mengkun; Zhou, Tingting; Li, Peifeng

doi:10.1016/j.omto.2022.03.002

Cited by 18 publications

(14 citation statements)

References 246 publications

(398 reference statements)

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“…Tissue-resident macrophages are derived from hematopoietic ancestral cells, usually settled in targeted tissues. They are known under various names, such as microglia in the brain, Langerhans cells in the epidermis, Kuffer cells in the liver, and macrophages in the alveoli [ 17 , 18 ]. Tissue-resident macrophages are the earliest immune cells that interact with cancer cells during tumor formation and are known to be important in the development of tumor growth and metastasis in cancer [ 19 ].…”

Section: Tumor-associated Macrophagesmentioning

confidence: 99%

Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment

Zhou

Chen

Zhang

et al. 2022

IJMS

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As an in-depth understanding of immunotherapy continues to grow, current anticancer therapy research is increasingly focused on the tumor microenvironment (TME). MicroRNAs (miRNAs) play crucial roles in the regulation of genetic information and expression and mediate interactions between tumor cells and components in the TME, such as tumor-associated macrophages (macrophages). Macrophages are abundant in the TME, and their different polarization directions can promote or inhibit tumor growth and progression. By regulating biological behaviors, such as macrophage recruitment, infiltration, and polarization, miRNAs can affect various molecular pathways to regulate tumor progression and treatment response. In this review, we discuss in detail the effects of macrophages on tumors and the multifaceted effects of miRNAs on macrophages. We also discuss the potential clinical applications and prospects of targeted therapy based on miRNAs, novel clinical biomarkers, and drug delivery systems.

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Section: Tumor-associated Macrophagesmentioning

confidence: 99%

Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment

Zhou

Chen

Zhang

et al. 2022

IJMS

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“…LncRNAs play a vital role in the occurrence, development, and metastasis of cancers and influence tumor initiation and development by affecting the TME. In the TME, TAMs are one of the most abundant cells that are primarily responsible for pro-tumoral processes and immune evasion/suppression ( 29 ) and the lncRNAs are involved in their regulation ( Table 1 ) ( 14 , 57 ). While some lncRNAs can induce macrophage recruitment, polarization, and M1/M2 phenotypic transition to accelerate cancer progression others inhibit tumor development by regulating TAMs.…”

Section: Lncrnas Regulate Tams and Influence Tumorigenesis And Progre...mentioning

confidence: 99%

“…LncRNAs are important participants in the crosstalk between tumor cells and macrophages, and they can be transferred along with multiple cellular components through intercellular messengers, such as sEV and microvesicles (MVs) ( 57 ). The sEV are 40-160 nm in diameter and are secreted by all cell types.…”

Section: The Involvement Of Sev In the Crosstalk Between Lncrnas And ...mentioning

confidence: 99%

Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination

et al. 2022

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Long noncoding RNAs (lncRNAs), which lack protein-coding ability, can regulate cancer cell growth, proliferation, invasion, and metastasis. Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment that have a significant impact on cancer progression. Small extracellular vesicles (sEV) are crucial mediators of intercellular communications. Cancer cell and macrophage-derived sEV can carry lncRNAs that influence the onset and progression of cancer. Dysregulation of lncRNAs, TAMs, and sEV is widely observed in tumors which makes them valuable targets for cancer immunotherapy. In this review, we summarize current updates on the interactions among sEV, lncRNAs, and TAMs in tumors and provide new perspectives on cancer diagnosis and treatment.

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“…In addition, probably because of their lower conservation, their expression patterns in cells or tissues are more specific than miRNAs or even mRNAs ( 19 ). lncRNAs act as molecular signaling activators, decoys, guides, or scaffolds that interact with a range of DNAs, RNAs, and proteins to influence their function, especially miRNAs ( 23 , 26 – 29 ). At least four patterns of lncRNA-miRNA interactions have been identified in mammals as follows: 1) lncRNAs act as competing endogenous RNAs (ceRNA)/sponges or decoys to bind miRNAs and release their target mRNAs; 2) lncRNAs as precursors are one of the sources of miRNAs; 3) lncRNAs compete with miRNAs to bind directly to mRNAs; and 4) miRNAs induce the degradation of lncRNAs ( 19 , 29 – 31 ).…”

Section: Introductionmentioning

confidence: 99%

The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish

Zhou

Leng²,

Wang³

et al. 2023

Front. Immunol.

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Research over the past two decades has confirmed that noncoding RNAs (ncRNAs), which are abundant in cells from yeast to vertebrates, are no longer “junk” transcripts but functional regulators that can mediate various cellular and physiological processes. The dysregulation of ncRNAs is closely related to the imbalance of cellular homeostasis and the occurrence and development of various diseases. In mammals, ncRNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The regulatory functions of lncRNAs on gene expression are usually mediated by crosstalk with miRNAs. The most predominant mode of lncRNA-miRNA crosstalk is the lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs). Compared to mammals, little attention has been given to the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species. In this review, we provide current knowledge about the teleost lncRNA-miRNA-mRNA axis, focusing on its physiological and pathological regulation in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and other stress-related immune responses. Herein, we also explored the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry. These findings contribute to an enhanced understanding of ncRNA and ncRNA-ncRNA crosstalk in fish biology to improve aquaculture productivity, fish health and quality.

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Noncoding RNA-mediated macrophage and cancer cell crosstalk in hepatocellular carcinoma

Cited by 18 publications

References 246 publications

Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment

Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment

Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination

The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish

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