Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination

Zhang, Lijie; Chen, Feng; Liang, Xiao-ru; Ponnusamy, Murugavel; Qin, Hao; Lin, Zhijuan

doi:10.3389/fonc.2022.1008856

Cited by 2 publications

(2 citation statements)

References 144 publications

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“…TAM is a vital part of the tumor microenvironment of GCs, influencing the malignant biological behaviors of GCs and playing an important role in the genesis and metastasis of GCs ( 174 – 176 ). In the tumor microenvironment, TAM produces a lot of inflammatory factors, growth factors, chemokines, and proteases through mutual crosstalk with GC cells and a variety of other cells, which play active roles in tumor growth, inhibition of apoptosis, angiogenesis, and lymphatic metastasis ( 177 – 179 ). Additionally, detecting the expression levels of these associated substances in GC patients helps judge the therapeutic effects and prognosis of GC.…”

Section: Prospects and Conclusionmentioning

confidence: 99%

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Qiu,

Lu,

et al. 2024

Front. Immunol.

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Gastric cancer (GC) is a malignant neoplasm originating from the epithelial cells of the gastric mucosa. The pathogenesis of GC is intricately linked to the tumor microenvironment within which the cancer cells reside. Tumor-associated macrophages (TAMs) primarily differentiate from peripheral blood monocytes and can be broadly categorized into M1 and M2 subtypes. M2-type TAMs have been shown to promote tumor growth, tissue remodeling, and angiogenesis. Furthermore, they can actively suppress acquired immunity, leading to a poorer prognosis and reduced tolerance to chemotherapy. Exosomes, which contain a myriad of biologically active molecules including lipids, proteins, mRNA, and noncoding RNAs, have emerged as key mediators of communication between tumor cells and TAMs. The exchange of these molecules via exosomes can markedly influence the tumor microenvironment and consequently impact tumor progression. Recent studies have elucidated a correlation between TAMs and various clinicopathological parameters of GC, such as tumor size, differentiation, infiltration depth, lymph node metastasis, and TNM staging, highlighting the pivotal role of TAMs in GC development and metastasis. In this review, we aim to comprehensively examine the bidirectional communication between GC cells and TAMs, the implications of alterations in the tumor microenvironment on immune escape, invasion, and metastasis in GC, targeted therapeutic approaches for GC, and the efficacy of potential GC drug resistance strategies.

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Section: Prospects and Conclusionmentioning

confidence: 99%

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Qiu,

Lu,

et al. 2024

Front. Immunol.

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“…EVs, including exocrine bodies, microvesicles and apoptotic bodies, are cell secreted nanoscale bilayer vesicles that stably reside in the extracellular fluid and participate as important messengers for cell communication, migration and angiogenesis [ 60 ]. Exocrine itself is related to the occurrence and development of CVD.…”

Section: Strategy and Mechanism Of Mitochondrial Transfer In Cvdmentioning

confidence: 99%

Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases

Sun

Jiang

et al. 2023

J Transl Med

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Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative treatment aimed at increasing mitochondrial number and improving mitochondrial function, has been emerged with great therapeutic potential. Substantial evidence indicates that mitochondrial transplantation improves cardiac function and outcomes in patients with CVD. Therefore, mitochondrial transplantation has profound implications in the prevention and treatment of CVD. Here, we review the mitochondrial abnormalities that occur in CVD and summarize the therapeutic strategies of mitochondrial transplantation for CVD.

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Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination

Cited by 2 publications

References 144 publications

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Exosome-mediated communication between gastric cancer cells and macrophages: implications for tumor microenvironment

Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases

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