Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis

Hsiao, Kuei‐Yang; Lin, Ya-Chi; Gupta, Sachin; Chang, Ning; Yen, Laising; Sun, Han; Tsai, Shaw-Jenq

doi:10.1158/0008-5472.can-16-1883

Cited by 548 publications

(500 citation statements)

References 38 publications

(48 reference statements)

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“…As reported, circRNAs could function as a miRNA sponge to regulate the gene expression [26, 27] and be involved in cancer processes [28-30]. To dissect the selected circRNAs’ potential functions, the circRNA and miRNA interactions were predicted by using Arraystar’s homemade miRNA target prediction software based on TargetScan and miRanda.…”

Section: Resultsmentioning

confidence: 99%

CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients

Zhao

Wang

et al. 2017

Cell Physiol Biochem

105

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Background/Aims: Lung adenocarcinoma, a form of non-small cell lung cancer with high lethality at an advanced stage, is becoming more common in women, non- or never-smokers, and even young adults. At present, there are still no effective early diagnosis methods for patients to be cured in a timely manner. Circular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease. However, it is still a puzzle as to which specific circRNAs are involved in the development of early-stage lung adenocarcinoma. Methods: Tumor samples and paired adjacent normal tissues from 4 patients with early-stage lung adenocarcinoma were selected to investigate the expression profile of circRNAs by using a high-throughput circRNA microarray. Bioinformatic analyses were conducted to screen those differentially expressed circRNAs. qRT-PCR and sequencing were performed to assure the microarray data. Results: A total of 357 circRNAs were dysregulated in the tumor samples, which suggests potential roles in lung cancer. qRT-PCR detection showed that five selected circRNAs were identical to the microarray data, and the potential circRNA-miRNA interactions were predicted. Conclusion: This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer.

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Section: Resultsmentioning

confidence: 99%

CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients

Zhao

Wang

et al. 2017

Cell Physiol Biochem

105

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“…[35] circRNACCDC66 was shown to accelerate the proliferation and metastasis of colon cancer, [36] circLARP4 regulated LARP4 expression by competitively binding to miR-424-5p in gastric cancer, [37] and circLMO7 was involved in the regulation of myogenic differentiation in cattle. circRNAs have been shown to play important roles in various cancers.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1‐Mediated Transcriptional Regulation of the Humanin Polypeptide Family

et al. 2018

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AbstractcircNOL10 is a circular RNA expressed at low levels in lung cancer, though its functions in lung cancer remain unknown. Here, the function and molecular mechanism of circNOL10 in lung cancer development are investigated using in vitro and in vivo studies, and it is shown that circNOL10 significantly inhibits the development of lung cancer and that circNOL10 expression is co‐regulated by methylation of its parental gene Pre‐NOL10 and by splicing factor epithelial splicing regulatory protein 1 (ESRP1). circNOL10 promotes the expression of transcription factor sex comb on midleg‐like 1 (SCML1) by inhibiting transcription factor ubiquitination and thus also affects regulation of the humanin (HN) polypeptide family by SCML1. circNOL10 also affects mitochondrial function through regulating the humanin polypeptide family and affecting multiple signaling pathways, ultimately inhibiting cell proliferation and cell cycle progression, and promoting the apoptosis of lung cancer cells, thereby inhibiting lung cancer development. This study investigates the functions and molecular mechanisms of circNOL10 in the development of lung cancer and reveals its involvement in the transcriptional regulation of the HN polypeptide family by SCML1. The results also demonstrate the inhibitory effect of HN on lung cancer cells growth. These findings may identify novel targets for the molecular therapy of lung cancer.

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“…In the study field of tumorigenesis and progression, recent studies have revealed that certain circRNAs are deregulated in many kinds of human cancers through high‐throughput RNA sequencing, such as gastric cancer, breast cancer, basal cell carcinoma, and cutaneous squamous cell carcinoma . Furthermore, several aberrant circRNAs have been identified as oncogenes or tumor suppressors . However, the expression and functions of most deregulated circRNAs remain largely unknown, and the mechanisms are rarely uncovered.…”

Section: Introductionmentioning

confidence: 99%