Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1‐Mediated Transcriptional Regulation of the Humanin Polypeptide Family

Nan, Aruo; Chen, Lijian; Zhang, Nan; Jia, Yangyang; Li, Xin; Zhou, Hui; Ling, Yihui; Wang, Zhishan; Yang, Chengfeng; Liu, Sijin; Jiang, Yiguo

doi:10.1002/advs.201800654

Cited by 73 publications

(58 citation statements)

References 42 publications

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“…circAGFG1 can facilitate the proliferation, migration and invasion of breast cancer cells in vitro and in vivo by regulating the miR-195-5p/CCNE1 axis [15]. circRNA circNOL10 facilitates transcription factor sex comb on midleg-like 1 (SCML1) expression by suppressing transcription factor ubiquitination to inhibit the progression of lung cancer [16]. Several circRNAs were characterized as oncogenes or tumor suppressors in renal RCC [11,[17][18][19]; however, there are still many circRNAs in RCC, and the roles urgently need to be investigated.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

et al. 2020

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Background: Circular RNAs (circRNAs), a novel type of noncoding RNA (ncRNA), are covalently linked circular configurations that form via a loop structure. Accumulating evidence indicates that circRNAs are potential biomarkers and key regulators of tumor development and progression. However, the precise roles of circRNAs in renal cell carcinoma (RCC) remain unknown. Methods: Through circRNA high-throughput sequencing of RCC cell lines, we identified the circRNA TLK1 (circTLK1) as a novel candidate circRNA derived from the TLK1 gene. qRT-PCR detected the mRNA, circRNA and miRNA expression levels in RCC tissues and cells. Loss-of function experiments were executed to detect the biological roles of circTLK1 in the RCC cell phenotypes in vitro and in vivo. RNA-FISH, RNA pull-down, dual-luciferase reporter, western blot and immunohistochemistry assays were used to investigate the molecular mechanisms underlying the functions of circTLK1. Results: circTLK1 is overexpressed in RCC, and expression is positively correlated with distant metastasis and unfavorable prognosis. Silencing circTLK1 significantly inhibited RCC cell proliferation, migration and invasion in vitro and in vivo. circTLK1 was mainly distributed in the cytoplasm and positively regulated CBX4 expression by sponging miR-136-5p. Forced CBX4 expression reversed the circTLK1 suppression-induced phenotypic inhibition of RCC cells. Moreover, CBX4 expression was positively correlated with VEGFA expression in RCC tissues. CBX4 knockdown significantly inhibited VEGFA expression in RCC cells. Conclusion: Collectively, our findings demonstrate that circTLK1 plays a critical role in RCC progression by sponging miR-136-5p to increase CBX4 expression. circTLK1 may act as a diagnostic biomarker and therapeutic target for RCC.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

et al. 2020

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“…CircNOL10 (hsa_circ_0000977) affects mitochondrial function by promoting the expression of the HN polypeptide family in lung cancer (Figure B) . Alterations in mitochondrial function trigger a variety of signaling pathways and ultimately inhibit cell proliferation and cell cycle progression and promote apoptosis in lung cancer cells, thereby significantly inhibiting lung cancer progression . It was found that circPTK2 inhibited transforming growth factor β‐induced mesenchymal‐epithelial transition (EMT) and cell invasion via the miR‐429/miR‐200b‐3p/TIF1γ axis in NSCLC .…”

Section: Tumor‐suppressive Circrnas and Cancersmentioning

confidence: 99%

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

et al. 2019

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internal ribosome entry site; LARP4, La-related protein 4; LATS1, large tumor suppressor kinase 1; lncRNAs, long noncoding RNAs; MIBC, muscle invasive bladder cancer; miRNA, microRNA; ncRNAs, noncoding RNAs; NF1, neurofibromin 1; Notch1, notch homolog 1; NSCLC, non-small cell lung cancer; OS, overall survival; PCK1, phosphoenolpyruvate carboxykinase 1; PDAC, pancreatic ductal adenocarcinoma; RBP, RNA-binding protein; RCAN1, regulation of Down syndrome critical region gene 1; sncRNAs, short noncoding RNAs; TIMP3, metalloproteinase inhibitor 3; USP28, ubiquitin-specific peptidase 28; YBX1, Y box binding protein 1. AbstractCircular RNAs (circRNAs) have a covalently closed circular conformation and are structurally stable. Those circRNAs with tumor-suppressive properties play an important role in tumorigenesis and metastasis and thus may be used as therapeutic targets of cancers. Herein, we review the current understanding of the classification of circRNAs and summarize the functions and mechanisms of circRNAs that have tumor-suppressive roles in various cancers, including liver cancer (circARSP91, circ-ADAMTS13, circADAMTS14, circMTO1, hsa_circ_0079299, and circC3P1), bladder cancer (circFNDC3B, circITCH, circHIPK3, circRNA-3, cdrlas, and circLPAR1), gastric cancer (circLARP4, circYAP1, hsa_cric_0000096, hsa_circ_0000993, and circPSMC3), breast cancer (circ_000911, hsa_circ_0072309, and circASS1), lung cancer (hsa_ circ_0000977, circPTK2, circ_0001649, hsa_circ_100395, and circ_0006916), glioma (circ_0001946, circSHPRH, and circFBXW7), and colorectal cancer (circITGA7 and hsa_circ_0014717). Thanks to their structural stability, these tumor-suppressive cir-cRNAs may be used as potential and potent therapeutic targets. Moreover, we propose a new method for the classification of circRNAs. Based on whether they can be translated, circRNAs can be divided into noncoding circRNAs and coding circRNAs. K E Y W O R D Sbiogenesis, cancer, circular RNA, mechanism, therapeutic target | INTRODUC TI ONThose RNAs that do not encode proteins are called ncRNAs. 1 Regulatory ncRNAs are divided into lncRNAs and sncRNAs. LncRNAs can be linear or circular. 2 Circular RNAs were first discovered in 1976. 3 Since then, a variety of circRNAs have been discovered. 4,5 CircRNAs are more resistant to exonuclease and are more stable than other lncRNAs. 3,6 They exist in exosomes and plasma. 6,7 Li et al identified more than 1000 circRNAs in human serum exosomes. 6 Li et al found 343 differentially How to cite this article:

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“…For example, it had been reported that hsa circ 100395 regulated lung cancer cell proliferation, migration and invasion through modulating the miR-1228/TCF21 pathway [45]. Nan et al revealed that circNOL10 could affect mitochondrial function through regulating the humanin polypeptide family and subsequently affect multiple signaling pathways, ultimately inhibiting lung cancer development [46].…”

Section: Discussionmentioning

confidence: 99%

Identification of hub driving genes and regulators of lung adenocarcinoma based on the gene Co-expression network

et al. 2020

Bioscience Reports

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Lung adenocarcinoma (LUAD) remains the leading cause of cancer-related deaths worldwide. Increasing evidence suggests that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) can regulate target gene expression and participate in tumor genesis and progression. However, hub driving genes and regulators playing a potential role in LUAD progression have not been fully elucidated yet. Based on data from The Cancer Genome Atlas database, 2837 differentially expressed genes, 741 DE-regulators were screened by comparing cancer tissues with paracancerous tissues. Then, 651 hub driving genes were selected by the topological relation of the protein–protein interaction network. Also, the target genes of DE-regulators were identified. Moreover, a key gene set containing 65 genes was obtained from the hub driving genes and target genes intersection. Subsequently, 183 hub regulators were selected based on the analysis of node degree in the ceRNA network. Next, a comprehensive analysis of the subgroups and Wnt, mTOR, and MAPK signaling pathways was conducted to understand enrichment of the subgroups. Survival analysis and a receiver operating characteristic curve analysis were further used to screen for the key genes and regulators. Furthermore, we verified key molecules based on external database, LRRK2, PECAM1, EPAS1, LDB2, and HOXA11-AS showed good results. LRRK2 was further identified as promising biomarker associated with CNV alteration and various immune cells’ infiltration levels in LUAD. Overall, the present study provided a novel perspective and insight into hub driving genes and regulators in LUAD, suggesting that the identified signature could serve as an independent prognostic biomarker.

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Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1‐Mediated Transcriptional Regulation of the Humanin Polypeptide Family

Cited by 73 publications

References 42 publications

RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

Identification of hub driving genes and regulators of lung adenocarcinoma based on the gene Co-expression network

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