Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Kim, Dong-Won; Chen, Ruosi; Sheu, Mary; Kim, Noori; Kim, Sooah; Islam, Nasif; Wier, Eric M.; Wang, Gaofeng; Li, Ang; Park, Angela; Son, Wooyang; Evans, Benjamin; Yu, Victoria; Prizmic, Vicky P.; Oh, Eugene; Wang, Zixiao; Yu, Jianshi; Huang, Weiliang; Archer, Nathan K.; Hu, Zhiqi; Clemetson, Nashay; Nelson, Amanda M.; Chien, Anna L.; Okoye, Ginette A.; Miller, Lloyd S.; Ghiaur, Gabriel; Kang, Sewon; Jones, Jace W.; Kane, Maureen A.; Garza, Luis A.

doi:10.1038/s41467-019-10811-y

Cited by 62 publications

(85 citation statements)

References 46 publications

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“…In the latter study, addition of a single local dose of dsRNA, 3 days after skin wounding in wild-type mice, increased the number of regenerated follicles, while addition of RNAse III to the site reduced the number of follicles [20]. TLR3 activation by dsRNA induced aldehyde dehydrogenase 1 family member A3 (ALDH1A3), an enzyme which converts retinol to retinoic acid in keratinocytes, and accumulation of RA was required for WIHN [70].…”

Section: Tlr3 and Tissue Repairmentioning

confidence: 93%

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

Turton

Thompson

Farkas

2020

IJMS

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Recognition of and response to pathogens and tissue injury is driven by the innate immune system via activation of pattern recognition receptors. One of the many patterns recognized is RNA and, while several receptors bind RNA, Toll-like receptor 3 (TLR3) is well placed for initial recognition of RNA molecules due to its localization within the endosome. There is a growing body of work describing a role for TLR3 in maintenance of vascular homeostasis. For example, TLR3 deficiency has been shown to play repair and remodeling roles in the systemic vasculature and in lung parenchyma. A hallmark of pulmonary arterial hypertension (PAH) is pulmonary vascular remodeling, yet drivers and triggers of this remodeling remain incompletely understood. Based on its role in the systemic vasculature, our group discovered reduced endothelial TLR3 expression in PAH and revealed a protective role for a TLR3 agonist in rodent models of pulmonary hypertension. This review will provide an overview of RNA signaling in the vasculature and how it relates to PAH pathobiology, including whether targeting double-stranded RNA signaling is a potential treatment option for PAH.

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Section: Tlr3 and Tissue Repairmentioning

confidence: 93%

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

Turton

Thompson

Farkas

2020

IJMS

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“…The samples were prepared from arm skins before (as controls) and 7 days after the treatment with a 1550 nm non-ablative fractional CO2 laser (as treated). The original data were published by Kim et al as "Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3" 13 in Nature Communications. We determined and discussed the role of the central nodes of the protein-protein interaction network of the DEGs to highlight "cytokine-mediated signaling pathway" as a major affected individual by laser irradiation.…”

Section: Methodsmentioning

confidence: 99%

Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin

et al. 2020

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Introduction: The widespread application of lasers in medicine, especially in the treatment of diseases implies more investigations to understand the precious molecular mechanism of the laser effect on the human body. In the present study, the prominent role of HERC6 in response to CO2 Laser therapy of human skin is investigated. Methods: The numbers of 16 gene expression profiles before and after the treatment with the CO2 laser are downloaded from Gene Expression Omnibus (GEO), and differentially-expressed genes (DEGs) are analyzed to find the significant DEGs. Gene ontology analysis revealed that HERC6 and a set of its neighbors played a significant role in response to laser application. Results: The expression changes of 52 significant DEGs were compared via heat map analysis and 27 significant DEGs were introduced as the critical genes which are involved in response to laser irradiation. "Thymidylate kinase activity" among 9 clusters of biological terms was highlighted as an important biological process related to the identified DEGs. HERC2 was proposed as a critical DEG which was related to several essential cellular processes in response to laser application. Conclusion: The findings from the present study indicate that HERC6 and the numbers of its first neighbors are involved in the essential cellular response to laser therapy of human skin.

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“…The microarray results of a document entitled "Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3" 12 were downloaded from Gene Expression Omnibus (GEO). The Data are presented as GSE131789/GPL15207 for 16 women that are treated to improve photo aging.…”

Section: Methodsmentioning

confidence: 99%

Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

et al. 2019

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Introduction: Laser therapy is known as an efficient approach in dermatology surgery. CO2 laser therapy is a gold standard treatment in skin surgery. This study aimed to evaluate the interferons change after CO2 laser surgery Methods: Significant differentially-expressed genes (DEGs) of arm skin after 7 days of treatment by the CO2 laser relative to the controls are downloaded from Gene Expression Omnibus (GEO) and are included in the protein-protein interaction network via a STRING database (an application of Cytoscape software). The central DEGs were identified and enriched via gene ontology by using Clue GO software. Results: A network including 78 DEGs and 100 neighbors was constructed and STAT1, MX1, ISG15, OAS1, IFIT1, IRF8, OASL, OAS2, and RSAD2 as hubs and STAT1, PTPRC, MX1, IRF8, ISG15, IL6, RORC, SAMSN1, and IFIT1 as bottlenecks were introduced. The cytokine-mediated signaling pathway, interferon gamma signaling, hepatitis C, interferon alpha/beta signaling, and the type I interferon signaling pathway were identified as 5 clusters of biological terms which are related to the central nodes. Conclusion: It can be concluded that the cytokine-mediated signaling pathway is the major pathway that is dysregulated after laser application in the treated skin.

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Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Cited by 62 publications

References 46 publications

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin

Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

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