Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

Rostami-Nejad, Mohammad; Rezaei‐Tavirani, Mostafa; Zadeh-Esmaeel, Mohammad-Mehdi; Rezaei-Tavirani, Sina; Akbari, Zahra; Esmaeili, Somayeh; Okhovatian, Farshad

doi:10.15171/jlms.2019.42

Cited by 12 publications

(15 citation statements)

References 25 publications

(24 reference statements)

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“…Gene ontology analysis leads to introducing biological terms which are different from the terms that were presented for the central DEGs in the previous report. 12 It seems that considering the expression properties of the significant DEGs is a suitable way to find complementary information about the critical genes beside the central genes. There are several documents about different parts of cells which are affected by laser irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…In the previous report 12 entitled "Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin after CO2 Laser Therapy", we downloaded GSE131789/ GPL15207 for 16 women from the Gene Expression Omnibus (GEO). The samples were prepared from arm skins before (as controls) and 7 days after the treatment with a 1550 nm non-ablative fractional CO2 laser (as treated).…”

Section: Methodsmentioning

confidence: 99%

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Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin

et al. 2020

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Introduction: The widespread application of lasers in medicine, especially in the treatment of diseases implies more investigations to understand the precious molecular mechanism of the laser effect on the human body. In the present study, the prominent role of HERC6 in response to CO2 Laser therapy of human skin is investigated. Methods: The numbers of 16 gene expression profiles before and after the treatment with the CO2 laser are downloaded from Gene Expression Omnibus (GEO), and differentially-expressed genes (DEGs) are analyzed to find the significant DEGs. Gene ontology analysis revealed that HERC6 and a set of its neighbors played a significant role in response to laser application. Results: The expression changes of 52 significant DEGs were compared via heat map analysis and 27 significant DEGs were introduced as the critical genes which are involved in response to laser irradiation. "Thymidylate kinase activity" among 9 clusters of biological terms was highlighted as an important biological process related to the identified DEGs. HERC2 was proposed as a critical DEG which was related to several essential cellular processes in response to laser application. Conclusion: The findings from the present study indicate that HERC6 and the numbers of its first neighbors are involved in the essential cellular response to laser therapy of human skin.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin

et al. 2020

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“…Laser applications in medicine have been promoted in different fields such as dermatology, dentistry, ophthalmology, and surgery. [1][2][3][4] There are many documents about the widespread use of lasers in skin treatment, especially in skin rejuvenation. [5][6][7] Skin aging is a natural process that occurs as people age.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Laser Effects on Skin Rejuvenation

et al. 2020

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Laser skin resurfacing has changed the approach of facial skin rejuvenation over the past decade. This article evaluates the laser effects on skin rejuvenation by the assessment of laser characteristics and histological and molecular changes, accompanied by the expression of proteins during and after laser-assisted rejuvenation of skin. It is important to note that different layers of skin with different cells are normally exposed to the sun’s UV radiation which is the most likely factor in aging and damaging healthy skin. To identify the expression of proteins, using validated databases and reviewing existing data could reveal altered proteins which could be analyzed and mapped to investigate their expression and their different effects on cell biological responses. In this regard, proteomics data can be used for better investigation of the changes in the proteomic profile of the treated skin. Different assessments have revealed the survival and activation of fibroblasts and new keratinocytes with an increase of collagen and elastin fibers in the dermis and the reduction of matrix metalloproteinases (MMPs) and heat shock proteins (HSPs) as a result of different lowpower laser therapies of skin. There are a wide range of biological effects associated with laser application in skin rejuvenation; therefore, more safety considerations should be regarded in the application of lasers in skin rejuvenation.

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“…[12][13][14] Laser therapy is evaluated in skin samples by PPI network analysis and the cytokine-mediated signaling pathway is introduced as a critically affected pathway in the patients. 15 In the present study, the differentially expressed proteins (DEPs) associated with radiation in MDA-MB-231 breast cancer cells are investigated to find a possible developmental way for the RT of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the SRC Inhibition Role in the Efficacy of Breast Cancer Radiotherapy

2019

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Introduction: Radiotherapy (RT) is an effective therapeutic method for preventing the recurrence of breast cancer after surgery. The development and improvement of RT are of interest to scientists. Possible improvement of RT via study of dysregulated proteins of breast cancer cell line MDA-MB-231 which is exposed to 10 Gray (Gy) radiation is aim of this study. Methods: Using protein-protein interaction (PPI) network analysis by means of running Cytoscape software via the STRING database, the up-regulated proteins of MDA-MB-231 breast cancer cells irradiated by a single and fractioned 10 Gy 137Cs γ-radiation were analyzed. The network was analyzed by using the Network analyzer to characterize the central genes. The action map was mapped for the queried genes and the added neighbors via CluePedia-STRING ACTIONS-v10.5- 20.11.2017. Results: The 14 differentially expressed proteins (DEPs) plus 10 neighbors interacted to construct a network. Among the 14 queried DEPs, FN1, CSPG4, LRP1, GSN, RTN4, and CTSD were highlighted as a complex set in the analysis. The analysis revealed that SRC as an added neighbor was activated by the critical DEPs. The activation of other oncogenes like AKT1 was also determined. Conclusion: The results indicate that the inhibition of SRC activity or the inhibition of its activators is a useful function of breast cancer RT

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Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

Cited by 12 publications

References 25 publications

Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin

Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin

Assessment of Laser Effects on Skin Rejuvenation

Assessment of the SRC Inhibition Role in the Efficacy of Breast Cancer Radiotherapy

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