Nonclassical Vitamin D Actions

Zittermann, Armin; Gummert, Jan

doi:10.3390/nu2040408

Cited by 101 publications

(98 citation statements)

References 81 publications

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“…The function of vitamin D was for a long time considered to be the maintenance of a normal skeletal architecture through calcium and phosphorus homeostasis, but in the last few decades, the extraskeletal effects of vitamin D became apparent, and its roles in the regulation of cell proliferation, differentiation, apoptosis, and in the immune modulation are increasingly recognized [9,10]. These actions of vitamin D are mediated by the vitamin D receptor (VDR), which after activation interacts with retinoid X receptor (RXR) to form a heterodimeric complex.…”

Section: Vitamin D: Synthesis and Functionsmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

141

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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Section: Vitamin D: Synthesis and Functionsmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

141

135

View full text Add to dashboard Cite

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“…Th e levels <50 nmol/L are considered as vitamin D defi ciency and those <30 nmol/L as severe vitamin D defi ciency, whereas vitamin D levels <20 nmol/L cause serious impairment of bone metabolism, i.e. rickets or osteomalacia, depending on age, as well as myopathy associated with physical inability 4,5 . As a steroid hormone, vitamin D directly or indirectly regulates 3% of the human genome function 6 .…”

Section: Introductionmentioning

confidence: 99%

Association Between Serum Vitamin D Level and Glaucoma in Women

Arar

Praveček

Miškić

et al. 2016

ACC

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SUMMARY -Th e aim of the study was to determine whether serum vitamin D level is lower in female patients with glaucoma as compared with control group. Th e mechanism by which vitamin D reduces intraocular pressure is not fully clarifi ed. Almost all tissues possess vitamin D receptor (VDR). Th e mice lacking VDR (VDR knockout mice) have greatly contributed to the understanding of the general vitamin D physiologic function. VDR has been found in some ganglion layer cells, external and internal nuclear layers of retina, and in retinal pigment epithelium, while VDR epitopes have also been found in the ciliary body epithelium, pointing to the role of this protein in eye physiology. Th e 1,25(OH)2D3 modulates expression of the genes involved in the regulation of intraocular pressure in non-human primates. Extracellular matrix can be remodeled by 1,25(OH)2D3 treatment. Actin disruption can lead to cell morphology alteration, trabecular meshwork relaxation and intraocular pressure reduction. Th is observational cross-sectional study included 90 female glaucoma subjects aged 45-55 and 50 glaucoma free female subjects as control group. Results of a pilot study conducted in 20 glaucoma subjects and 20 control subjects are presented below. All study subjects underwent history taking, complete ophthalmologic examination and serum vitamin D determination. Th e mean serum vitamin D level was 32.31 nmol/L in glaucoma patients and 64.17 nmol/L in control subjects. Serum vitamin D level was statistically signifi cantly lower in glaucoma patients as compared with control group (p<0.05).

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“…Vitamin D deficiency was also found to be associated with insulin resistance via a mechanism involving stimulation of the expression of insulin receptors. Research has also shown that the regulation of intra-and extracellular calcium and modulators have profound effects on the immune system [7].…”

Section: Introductionmentioning

confidence: 99%

Value of follicular fluid vitamin D in predicting the pregnancy rate in an IVF program

Firouzabadi

Rahmani

Rahsepar

et al. 2013

Arch Gynecol Obstet

102

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Purpose This study investigated whether there is a correlation between levels of 25OH-D in the follicular fluid and the serum of infertile women and the results of IVF and rates of pregnancy. The association between the levels of 25OH-D in the follicular fluid and the vitamin D repletion status was also assessed. Methods Two hundred and twenty-one infertile women participated in an IVF cycle from 2010 to 2011 in a prospective observational study. Serum and follicular fluid were collected for vitamin D analysis. Deficient, insufficient, and sufficient levels of vitamin D were defined as 10, 10-29, and 30-100 ng/ml, respectively. IVF cycle parameters and clinical pregnancy rates were also compared with the vitamin D level. Results The levels of vitamin D deficiency, insufficiency, and sufficiency were 22.6, 70.1, and 7.2 %, respectively. The fertilization rates associated with these three levels of vitamin D were 43.17, 53.37, and 58.77 %, respectively, (P = 0.054), and the implantation rates were 17.33, 15.26, and 18.75 %, respectively, (P = 0.579). No significant correlation was seen between the pregnancy rate and the serum vitamin D level (P = 0.094) or the follicular vitamin D level (P = 0.170). The serum and follicular fluid vitamin D levels showed a significant correlation (P = 0.000). Conclusion Although vitamin D is an important hormone in the human body, no correlation was found between the serum and follicular vitamin D level and the pregnancy rate in the IVF cycle.

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Nonclassical Vitamin D Actions

Cited by 101 publications

References 81 publications

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Association Between Serum Vitamin D Level and Glaucoma in Women

Value of follicular fluid vitamin D in predicting the pregnancy rate in an IVF program

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