Noncardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy

Hulley, Stephen B.; Furberg, Curt D.; Barrett‐Connor, Elizabeth; Cauley, Jane A.; Grady, Deborah; Haskell, William L.; Knopp, Robert H.; Lowery, Maureen H.; Satterfield, Suzanne; Schrott, Helmut G.; Vittinghoff, Eric; Hunninghake, Donald B.; Group, for the HERS Research

doi:10.1001/jama.288.1.58

Cited by 572 publications

(93 citation statements)

References 23 publications

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“…In contrast, estrogen-only HTMP has not been associated with a significant increase in the risk of BC. This effect was support by data from the Women's Health Initiative study which followed women using estrogen-only HTMP for up to 7 years [65,66,67]. It seems that progesterone does have a negative effect on BC, but this effect is not seen in endometrial and ovarian cancer.…”

Section: Hormone Therapy After Menopausementioning

confidence: 77%

Influence of Lifestyle Factors on Breast Cancer Risk

et al. 2014

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Breast Cancer (BC) is a life-changing event. Compared to other malignancies in women, BC has received considerably more public attention. Despite improved neoadjuvant, adjuvant, and palliative treatment strategies for each characteristic molecular BC subtype, recommendations for evidence-based preventive strategies for BC treatment are not given equivalent attention. This may be partly due to the fact that high-quality long-term prevention studies are still difficult to carry out and are thus underrepresented in international studies. The aim of this review is to discuss the most relevant lifestyle factors associated with BC and to identify and discuss the evidence supporting practical prevention strategies that can be used in everyday clinical practice.

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Section: Hormone Therapy After Menopausementioning

confidence: 77%

Influence of Lifestyle Factors on Breast Cancer Risk

et al. 2014

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“…2 Many studies have been published since these recommendations were released, including the first report from the Women's Health Initiative (WHI), 3 a large randomized primary prevention trial, and the Heart and Estrogen/ progestin Replacement Study (HERS), 4 a secondary prevention trial reporting multiple outcomes. [4][5][6] This review was initiated to aid the current USPSTF in making new recommendations that will be released this fall. The focus of the USPSTF is to develop recommendations on screening, counseling, and chemoprophylaxis for asymptomatic populations.…”

mentioning

confidence: 99%

Postmenopausal Hormone Replacement Therapy

Nelson¹,

Humphrey²,

Nygren³

et al. 2002

JAMA

920

504

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PPROXIMATELY 38% OF POSTmenopausal women in the United States in 1995 used h o r m o n e r e p l a c e m e n t therapy (HRT), estrogen with or without progestin, to treat symptoms of menopause and prevent chronic conditions such as cardiovascular disease and osteoporosis. 1 Although treatment of symptoms of menopause, such as hot flashes and urogenital atrophy, among others, is a common indication for short-term use, potential preventive effects of HRT on long-term health outcomes have become an increasingly important consideration.In 1996, the second US Preventive Services Task Force (USPSTF) determined that there was insufficient evidence to recommend for or against HRT for all women but thought that individual decisions should be based on patient risk factors, an understanding of the probable benefits and harms, and personal preferences. 2 Many studies have been published since these recommendations were released, including the first report from the Women's Health Initiative (WHI), 3 a large randomized primary prevention trial, and the Heart and Estrogen/ progestin Replacement Study (HERS), 4 a secondary prevention trial reporting multiple outcomes. [4][5][6] This review was initiated to aid the current USPSTF in making new recommendations that will be Author Affiliations and Financial Disclosures are listed at the end of this article.

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“…Breast cancer is influenced by multiple risk factors, which include the risk factors such as those linked to the hazardous effects of hormonal exposures such as early age at menarche, late age at menopause [10], fewer number of children and null parity, late age at first birth [11], little or no breastfeeding and long-term use of hormone replacement therapy (HRT) [12,13,14,15].…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Awareness and Approach toward Exposure to Diverse Patterns of Hormones among Women in Northern Saudi Arabia

ahmed¹,

Alharbi²,

Alreshidi³

et al. 2017

AJCP

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Background: Several studies have well-established the relationship between breast cancer and etiological hormonal factors. Therefore, the aim of this study was to determine breast cancer related awareness and approach toward exposure to diverse patterns of hormones among women in Northern Saudi Arabia. Methodology: This is a cross sectional survey included 400 Saudi females' volunteers living in the city of Hail, Northern Saudi Arabia. Knowledge, awareness and approach toward exposure to diverse patterns of hormones and breast cancer risk were evaluated using different variables during interview. Results: On asking the participants the question "Does the over exposure to hormones (ER) increases the risk of breast cancer" Out of 387 respondents, 47.5% answered yes increases the risk of breast cancer. On asking the participants the question "Does early puberty and late menopause increase the risk of breast cancer" Out of 395 respondents, 35.2% answered yes increases the risk of breast cancer. Conclusion: Knowledge of hormonal breast cancer risk factors is not so strong so as to achieve the intended values in Northern Saudi Arabia. Knowledge of breast cancer risk factors can powerfully participate to the breast cancer prevention struggles, which will have the chief results mainly if started at an early age and continued over a lifetime.

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Noncardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy

Cited by 572 publications

References 23 publications

Influence of Lifestyle Factors on Breast Cancer Risk

Influence of Lifestyle Factors on Breast Cancer Risk

Postmenopausal Hormone Replacement Therapy

Breast Cancer Awareness and Approach toward Exposure to Diverse Patterns of Hormones among Women in Northern Saudi Arabia

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