Influence of Lifestyle Factors on Breast Cancer Risk

Abstract

Breast Cancer (BC) is a life-changing event. Compared to other malignancies in women, BC has received considerably more public attention. Despite improved neoadjuvant, adjuvant, and palliative treatment strategies for each characteristic molecular BC subtype, recommendations for evidence-based preventive strategies for BC treatment are not given equivalent attention. This may be partly due to the fact that high-quality long-term prevention studies are still difficult to carry out and are thus underrepresented in international studies. The aim of this review is to discuss the most relevant lifestyle factors associated with BC and to identify and discuss the evidence supporting practical prevention strategies that can be used in everyday clinical practice.

Implication of oestrogen in the development of breast cancer: a brief narrative review

“…7 This idea of lifestyle confounders of breast cancer risk remains credible as it has been reported by other authors and the need for evidence-based preventive methods remains a concern. [29][30][31] In Nigeria, there is the implicit awareness that obesity need be screened as one of specific risk factors of breast cancer. 32 However, whether these lifestyle confounding variables are assessed in breast cancer screening programs is yet to be articulated.…”

Genetic polymorphisms and protein expression of P53 and BRCA1 in preneoplastic and neoplastic rat mammary glands

“…Breast cancer has been increasing in incidence and remains the most frequent and the deadliest cancer in women worldwide (1). Many factors contribute to the development of breast cancer such as age, life style and genetic factors (2). However, in many cases there is no obvious predisposing factor, supporting the view that a variety of environmental carcinogens may play a major role in the initiation of breast cancer (3).…”

siRNA: A Promising New Tool for Future Breast Cancer Therapy

“…[1] Major factors associated with an increased risk of breast cancer development include individual lifestyle, family history of breast cancer, and genetic predisposition. [2,3] Regarding individual lifestyle, several studies have yielded consistent results suggesting that obesity, smoking, and alcohol consumption have a positive correlation with an increased risk of developing breast cancer. [2] Women with a family history of breast cancer appear to have an increased risk of developing the disease; in a study, compared to women with no affected relatives, women with one, two, or three or more first degree relatives affected with breast cancer had risk ratios of, respectively, 1.80, 2.93, and 3.90, suggesting a positive correlation with breast cancer development.…”

“…[2,3] Regarding individual lifestyle, several studies have yielded consistent results suggesting that obesity, smoking, and alcohol consumption have a positive correlation with an increased risk of developing breast cancer. [2] Women with a family history of breast cancer appear to have an increased risk of developing the disease; in a study, compared to women with no affected relatives, women with one, two, or three or more first degree relatives affected with breast cancer had risk ratios of, respectively, 1.80, 2.93, and 3.90, suggesting a positive correlation with breast cancer development. [4] Although approximately 20% to 25% of breast cancer patients show a family history of breast cancer, only 5% to 10% of breast cancer cases exhibit an autosomal dominant inheritance, with high-risk predisposition alleles conferring as high as an 85% lifetime risk of developing breast cancer.…”