Nonbullous neutrophilic dermatosis: Sweet’s syndrome, neonatal lupus erythematosus, or both?

Barr, Keira; Connell, Florence O’; Wesson, Stanton K.; Vincek, Vladimir

doi:10.1007/s10165-008-0145-x

Cited by 14 publications

(14 citation statements)

References 18 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were 3 cases of neonatal lupus erythematosus (NLE) presenting with neutrophilic dermatosis, which were again self-limited with a positive outcome. 23,24 Four children had a primary immunodeficiency, including 2 presented here, 1 other case of humoral immunodeficiency, 5,25 and 1 autosomal recessive chronic granulomatous disease. 26 In the 2 cases of humoral immunodeficiency, the rash was protracted and refractory to treatment.…”

Section: Results Of the Literature Reviewmentioning

confidence: 95%

Neonatal Sweet Syndrome: A Potential Marker of Serious Systemic Illness

Gray

Bock²,

Ziegler

et al. 2012

Pediatrics

View full text Add to dashboard Cite

Sweet syndrome is an inflammatory disease characterized by fever and painful erythematous plaques with a dermal neutrophilic infiltrate. It is most common in adults, where it is often parainflammatory or paraneoplastic, but is rare in children. We describe 3 cases of neonatal Sweet syndrome, including 1 patient who had myelodysplastic syndrome and immunodeficiency, the first report of a premalignancy underlying infantile Sweet syndrome. We reviewed the literature on patients presenting with neutrophilic dermatosis in the first 6 months of life. Of 20 cases, 6 had a probable viral etiology, 4 primary immunodeficiencies, 3 neonatal lupus syndrome, 1 gastrointestinal involvement, 1 HIV, and 5 probable genetic cases. Three of these had chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome, caused by mutations in the PSMB8 gene. Most children who presented within the first 6 weeks of life had either a serious underlying condition, such as primary immunodeficiency, or a genetic Sweet syndrome, with 2 fatalities among this latter group. The outcome of postinfective cases was good. Extracutaneous involvement was unusual, whereas postinflammatory scarring and cutis laxa occurred in a minority of patients. In conclusion, Sweet syndrome in the neonatal period often heralds a serious underlying disorder and requires thorough investigation.

show abstract

Section: Results Of the Literature Reviewmentioning

confidence: 95%

Neonatal Sweet Syndrome: A Potential Marker of Serious Systemic Illness

Gray

Bock²,

Ziegler

et al. 2012

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Our Case 1 is the third. Three cases of Sweet's syndrome-like nonbullous neutrophilic dermatosis and neonatal lupus have been reported [14, 15], as well as three cases of hydralazine-induced SLE and Sweet's [16–18], but will not be discussed here. In addition, cases with some features of SLE that did not meet full criteria for SLE were excluded from this paper.…”

Section: Discussionmentioning

confidence: 99%

Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Barton

Pincus

Yazdany

et al. 2011

Case Reports in Rheumatology

View full text Add to dashboard Cite

Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.

show abstract

“…1,2,[4][5][6][7][8][9][10][11][12] The results are tabulated (Table II) and compared with our 7 cases (Table I).…”

Section: Final Diagnosesmentioning

confidence: 97%

“…The differential diagnosis for neutrophilic dermatoses includes Sweet syndrome (SS), pyoderma gangrenosum, rheumatoid neutrophilic dermatosis, palisaded neutrophilic and granulomatous dermatosis, Behçet disease, and bowel-associated dermatosis arthritis syndrome. 1 These conditions are thought to represent a hypersensitivity immune response in conjunction with infection, malignancy, medication, or various autoimmune diseases. 2 SS, or acute febrile neutrophilic dermatosis, was first described by Robert Sweet in 1964 3,4 , and has 4 cardinal features: fever, leukocytosis, tender red plaques, and a histologic picture characterized by a predominantly neutrophilic dermal infiltration.…”

mentioning

confidence: 99%

“…SS has also been reported in single cases of drug-induced LE, neonatal LE, and subacute cutaneous LE. [1][2][3][4][5][6][7][8][9][10][11][12] There are various inflammatory conditions in the setting of LE accompanied by prominent tissue neutrophilia, including: bullous lupus, neonatal lupus, urticarial vasculitis, urticaria, leukocytoclastic vasculitis, palisading granulomas, amicrobial pustulosis, and neutrophilic dermatosis. 2,4,[13][14][15][16][17][18][19][20][21][22] We report 7 patients with a distinct and unusual eruption consisting of a Sweet-like neutrophilic dermatosis (SLND), in conjunction with previous or concomitant LE, and discuss the relevance of these findings.…”

mentioning

confidence: 99%

See 1 more Smart Citation