Nonbladder Related Symptoms in Patients With Interstitial Cystitis

Erickson, Deborah; MORGAN, KELLY C.; Ordille, Sarah; Keay, Susan; Xie, Sharon X.

doi:10.1097/00005392-200108000-00034

Cited by 16 publications

(27 citation statements)

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“…Some symptoms of CPS, especially pelvic pain, may be indistinguishable from those of interstitial cystitis (IC) [3,4]. The latter condition is more frequently seen in women than in men, which means that the possibility of IC in men is often disregarded and the diagnosis is missed, especially if non-bladder related symptoms are present [5]. Not only is the diagnosis of IC in general made much more frequently than it was 20 years ago, but also, according to Parson [6], a recent survey has shown a femaleto-male ratio of 5:1, which is substantially lower than previously believed (10:1).…”

Section: Introductionmentioning

confidence: 99%

Chronic pain in urological diseases: a clinical review

et al. 2008

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AbstractChronic pain is the central problem in a variety of urological diseases. Pain is an unpleasant sensory and emotional experience associated with either actual or potential tissue damage, or described in terms of such damage. The aim of this research was to update knowledge about the ultrastructural, clinical, psychological and therapeutic aspects of chronic pain in urological diseases, in particular in chronic pelvic syndrome. In this paper we have revisited the most significant and discussed articles published in the last twenty five years, with particular references on the 2008 European Guidelines, searching key words (chronic pelvic pain syndrome, chronic pelvic pain, chronic prostatitis, interstitial cystitis, prostatodynia, urological disease) and data with a high level of evidence. The articles that we have analyzed show that pain is characterized by an initial tissue injury that can lead to sensitization, which is a decrease in the intensity of the stimulus needed to elicit a response by the nerve, involving the peripheral and central nervous systems. The chronic pain state is characterized by loss of inhibitory interneurons, establishment of aberrant excitatory synaptic connections and long-term potentiation of response due to changes in sensitivity of nerve synapses. Stress and hormones might also play a role in central sensitization. Pain also has a cognitive and emotional component. It is very difficult to treat, given the complex nature of the response and the interaction of physiological aspects

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Section: Introductionmentioning

confidence: 99%

Chronic pain in urological diseases: a clinical review

et al. 2008

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“…Dorsal root ganglia; Capsaicin; Nociception; Transient receptor potential vanilloid receptor 1; Protein kinase C; Phosphorylation; Desensitization; Interstitial cystitis; Diaryl piperazine Interstitial cystitis (IC) is a chronic pelvic pain syndrome of humans [2,8,14]. A comparable disorder, feline interstitial cystitis (FIC), has been identified in domestic cats [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, our observation that non-bladder FIC neurons exhibit these changes, suggests that the abnormalities in afferent neuron excitability may occur in DRG neurons innervating structures outside the pelvic cavity. This may explain the observation that symptoms of interstitial cystitis extend beyond the bladder, affecting other organs in the body [2,8]. …”

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confidence: 98%

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Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis

Sculptoreanu

Groat

Buffington

et al. 2005

Neuroscience Letters

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Interstitial cystitis (IC) is a painful disorder which affects urinary bladder function in cats and humans. We have used patch clamp techniques to examine the possibility that the properties of primary afferent neurons are changed in feline interstitial cystitis (FIC). We measured transient receptor potential vanilloid receptor 1 (TRPV1) responses to capsaicin (CAPS) in dorsal root ganglion (DRG) neurons (L4-S3) from normal cats and cats with FIC. We show that FIC neurons are increased in size and exhibit CAPS responses which are increased in amplitude and desensitize slowly. CAPS responses desensitized seven times slower in FIC neurons. Phorbol 12,13-dibutyrate (PDBu), an activator of PKC, slowed the desensitization of CAPS responses in normal cat bladder and nonbladder neurons, but had no effect in FIC neurons. Bisindolylmaleimide, an inhibitor of PKC, reversed the PDBu effects in normal cat neurons and normalized the desensitization of CAPS responses in FIC neurons. Our data suggest that FIC afferent neurons exhibit abnormal CAPS responses. The latter may be due to enhanced endogenous activities of PKC. KeywordsDorsal root ganglia; Capsaicin; Nociception; Transient receptor potential vanilloid receptor 1; Protein kinase C; Phosphorylation; Desensitization; Interstitial cystitis; Diaryl piperazine Interstitial cystitis (IC) is a chronic pelvic pain syndrome of humans [2,8,14]. A comparable disorder, feline interstitial cystitis (FIC), has been identified in domestic cats [3,4]. Previous studies revealed an increased density of peptidergic afferent nerves in the bladders of FIC cats suggesting that an abnormality of afferent pathways might contribute to the disorder [5,12].Bladder pain and hyperactivity can be induced by activation of capsaicin (CAPS)-sensitive, unmyelinated (C-type) afferent nerves [7,18,20]. Intravesical administration of CAPS induces bladder pain; whereas desensitization of C-fiber bladder afferents with intravesical administration of resiniferatoxin, an ultrapotent CAPS analog, has been reported to reduce bladder overactivity [18]. The CAPS sensitivity of C-fiber afferent nerves is conferred by the presence of a temperature-acid sensing receptor called the transient receptor potential vanilloid receptor 1 (TRPV1) [6,10]. Protein kinase C phosphorylation of TRPV1 has been reported to sensitize the response of this receptor to agonists [1,22]. Here, we investigated the properties of primary afferent neurons in lumbo-sacral dorsal root ganglia (DRG) from normal cats and To identify FIC in cats, we utilized criteria as previously described [4]. Cells were isolated from L4-S3 DRG of cats using methods previously described for primary cultures of DRG neurons of adult rat [15]. In some experiments, the population of DRG neurons that innervate the urinary bladder was labeled by retrograde axonal transport of a fluorescent dye, fast blue (FB, 4% w/v, Polyloy, Gross Umstadt, Germany [21]). In these experiments, dye-labeled primary afferent neurons were identified using an inverted phase-contr...

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“…Além disso, a CI sendo considerada uma síndrome de dor crônica tem uma maior associação com outras síndromes álgicas muitas vezes com sobreposição dos quadros clínicos. Isso pode acontecer com associações entre a CI e fibromialgia, vulvodínea, síndrome do intestino irritável, disfunção temporomandibular, síndrome de fadiga crônica e dor pélvica crônica (13)(14)(15)(16) . Alguns estudos mostram que essas síndromes podem ocorrer independentemente ou associadas umas com as outras (isto é, ocorrendo como comorbidades), mesmo fora do contexto da CI (13,14) .…”

Section: Cistite Intersticial E Polimorfismosunclassified

Análise de polimorfismos de nucleotídeo único na cistite intersticial

Cassão¹

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DedicatóriaA minha família pelos ensinamentos, pelos exemplos de vida e pelo apoio incondicional. A minha querida esposa e companheira Paula, que sempre me incentivou e tornou possível a realização deste sonho. "All our science, measured against reality, is primitive and childlike -and yet it is the most precious thing we have". Albert Einstein 1879-1955Agradecimentos Ao Professor Dr. Homero Bruschini, pela oportunidade, pela confiança, pelos inúmeros conselhos e ensinamentos que contribuíram muito para o meu crescimento pessoal e profissional. À Professora Dra. Sabrina Reis pelo carinho e pelos ensinamentos em pesquisa e genética.Aos colegas urologistas que fazem parte do grupo de Bexiga Neurogênica do HCFMUSP, aos residentes da urologia e aos funcionários da urologia por sua dedicação diária no atendimento e cuidados dos pacientes que participaram neste estudo.À equipe do LIM 55 que me acolheu com muito carinho e pelo imprescindível auxílio no aprendizado das técnicas moleculares.Às pacientes com Cistite Intersticial, motivo deste estudo. À FAPESP pelo apoio ao projeto e financiamento dos materiais. rs1800896, rs1800471, rs1800629, rs361525, rs1800497, rs6311, rs6277, rs6276, rs6313, rs2835859, rs11127292, rs2243248, rs6887695, rs3212227, rs1799971, rs12579350, rs3813034, rs6746030. A genotipagem foi realizada através da técnica de PCR em tempo real (q-PCR) e correlacionada com o diagnóstico de CI e com a intensidade dos sintomas álgicos. RESULTADOS: O alelo polimórfico (T) do SNP rs11127292 foi mais frequente nas pacientes com CI em relação ao grupo controle (p:0,01). O alelo polimórfico (T) do SNP rs6311 foi significativamente mais frequente nas pacientes com dor mais intensa (p:0,03). A frequência do alelo selvagem (A) do SNP rs1799971 foi maior em pacientes com dor leve a moderada (p:0,04 INTRODUCTION: Interstitial cystitis (IC) or painful bladder syndrome (PBS) is a chronic syndrome characterized by the presence of bladder/pelvic pain or discomfort and voiding symptoms such as urgency and increased urinary waking and night-time frequency in the absence of another identifiable cause to justify these symptoms. So far, there is no diagnostic test or marker to establish the presence of IC. Thus, the diagnosis is predominantly clinical, based on signs and symptoms and dependent on the exclusion of other urological diseases. The difficulty in the diagnosis and treatment of these patients reflects the little that is known about IC physiopathology and about the genetic background of the disease. The identification of new markers may provide a better understanding and management of the syndrome. As an attempt to identify genetic markers that may be associated with IC, we evaluated the presence of some genetic polymorphisms, single nucleotide polymorphisms (SNPs), in the DNA of patients with the diagnostic criteria of IC, and we compared their prevalence among IC patients and with a control group representative of the general population. The correlation of these polymorphisms considering IC and pain intensity ...

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Nonbladder Related Symptoms in Patients With Interstitial Cystitis

Cited by 16 publications

References 0 publications

Chronic pain in urological diseases: a clinical review

Chronic pain in urological diseases: a clinical review

Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis

Análise de polimorfismos de nucleotídeo único na cistite intersticial

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