Nonatopic eczema in elderly women: Effect of air pollution and genes

Hüls, Anke; Abramson, Michael J.; Sugiri, Dorothea; Fuks, Kateryna; Krämer, Ursula; Krutmann, Jean; Schikowski, Tamara

doi:10.1016/j.jaci.2018.09.031

Cited by 40 publications

(36 citation statements)

References 49 publications

(61 reference statements)

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“…7 Li et al 8 also reported a positive relationship between ambient air pollutants and eczema in western China, with a negative association with increased relative humidity. 8 Consistent with these Chinese reports are those from a German study by Huls et al, 9 which demonstrated that incident eczema in 843 persons older than age 55 was associated with increased levels of NO 2 , NOx, PM2.5, and PM10 9 . In this German study, the impact of these pollutants was more notable in nonatopic eczema than atopic eczema.…”

Section: Pollutant Impacts On Eczema Exacerbationmentioning

confidence: 53%

“…Intriguingly, the bacterial airway microbiome also modifies the impact of viruses in asthma. In a recent study of in 413 children (ages[6][7][8][9][10][11][12][13][14][15][16][17] assessing seasonal use of omalizumab to decrease asthma exacerbation in the fall, McCauley et al41 examined the relationship between the nasal microbiome and asthma exacerbation. They observed that bacterial populations dominated by Moraxella were associated with increased risk of disease and eosinophil activation and that when Streptococcus species dominant, increased risk of RV infection occurred.…”

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confidence: 99%

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The “envirome” and what the practitioner needs to know about it

Peden

2019

Annals of Allergy, Asthma & Immunology

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Ambient air pollutant exposure has been associated with development of both asthma and eczema. Mechanistic plausibility for the effect of pollutants on atopy has been shown in sensitization studies with diesel exhaust particles and in epigenetic studies of circulating T cells from children with increased exposure to ambient pollutants. 2. Environmental public policy that reduces pollution has clearly been shown to decrease community risk for asthma and to improve lung function 3. Microbiome studies have shown that colonization with specific microbes is associated with increased asthma risk. Colonizations with Staphylococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae are all associated with increased risk for asthma events. Colonization with other organisms may be protective. 4. Endotoxin exposure in early life is often associated with decreased atopic sensitization, although endotoxin exposure may worsen nonatopic asthma and may augment response to allergens in sensitized individuals. 5. Maternal and perinatal stress, household and neighborhood violence, and poor housing stock all promote development of allergic disease and asthma.

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Section: Pollutant Impacts On Eczema Exacerbationmentioning

confidence: 53%

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confidence: 99%

The “envirome” and what the practitioner needs to know about it

Peden

2019

Annals of Allergy, Asthma & Immunology

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“…The main pruritic skin disorders necessitating differentiation from elderly AD, especially from senile-onset or senile-recurrence types of elderly AD, are as follows: asteatotic dermatitis, nummular dermatitis, contact dermatitis, chronic prurigo, adverse drug reactions, scabies, papuloerythroderma of Ofuji [29], and cutaneous T cell lymphoma [30]. However, certain disorders, including non-atopic eczema in the elderly [31], chronic eczematous eruption of aging [32], and senile erythroderma [33,34], may be characterized by clinical findings similar to elderly AD, and differential diagnosis from elderly AD may be difficult in some cases. Thus, it could be speculated that pruritic skin disorders in the elderly have etiological similarities to elderly AD [12,17] with regards to the impact of aging on pathogenic factors (e.g., physical skin barrier, innate and adaptive immunity, skin microbiota, and environmental stimuli) that characterize their symptoms and signs.…”

Section: Diagnosis Of Elderly Admentioning

confidence: 99%

Atopic Dermatitis in Older Adults: A Review of Treatment Options

Tanei

2020

Drugs Aging

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Atopic dermatitis (AD) in older adults (elderly AD) has recently emerged as a newly defined subgroup of AD. When selecting treatment options, clinical characteristics of elderly AD and age-specific factors of older patients must be considered. As in other age groups, regular application of moisturizers in combination with topical corticosteroids and calcineurin inhibitors, adjunctive administration of oral antihistamines/anti-allergic drugs, and avoidance of exacerbating factors comprise basic treatments for elderly AD. For moderate-to-severe cases and/or in those with a decreased ability to use topical treatments, powerful anti-inflammatory treatments may become necessary as additional treatment options. While low-dose oral corticosteroids may be useful for cases of elderly AD, careful attention should be paid to adverse effects. Oral cyclosporine (ciclosporin) is less commonly used due to the increased risk of malignancy and organ toxicity in older patients with AD.

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“…5 There have been relatively few studies of the risk factors for eczema in adults. 6 In paediatric studies, higher levels of ambient air pollutants have been associated with increased eczema prevalence. 7 It has been proposed that air pollutants may generate reactive oxygen species which damage the outer-most layer of the skin through oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

“…A recent longitudinal analysis of middle aged German women, which investigated the influence of traffic related air pollution on lung function, inflammation and Aging (SALIA) found that baseline concentrations of traffic-related air pollution (TRAP) markers (NO 2 , NO x , PM 2.5 and PM 10 ) were significantly associated with increased odds of incident eczema over a 19-year follow-up period, these associations being stronger for NAE. 6 Therefore, environmental factors, including air pollution, might be important for development of eczema in middle age, particularly NAE. These findings need to be replicated using similar longitudinal data to draw firmer conclusions.…”

Section: Introductionmentioning

confidence: 99%

Association between ambient air pollution and development and persistence of atopic and non-atopic eczema in a cohort of adults

Lopez

Lodge

Bui

et al. 2020

Preprint

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Background: There is limited information on risk factors for eczema in adults. Recent evidence suggests that air pollution may be associated with increased incidence of eczema in adults. We aimed to assess this possible association. Methods: Ambient air pollution exposures (distance from a major road, nitrogen dioxide [NO2], fine particulate matter with an aerodynamic diameter [?]2.5 μm [PM2.5]) were assessed for the residential address of Tasmanian Longitudinal Health Study participants at ages 43 and 53 years. Eczema incidence (onset after age 43 years), prevalence (at 53 years) and persistence were assessed from surveys, while sensitisation was assessed using skin prick tests. The presence or absence of eczema and sensitisation was classified into four groups: no atopy or eczema, atopy alone, non-atopic eczema, and atopic eczema. Adjusted logistic and multinomial regression models were fitted to estimate associations between ambient air pollution and eczema, and interaction by sex was assessed. Results: Of 3153 participants in both follow ups, 2369 had valid skin prick tests. For males, a 2.3 ppb increase in baseline NO2 was associated with increased risk of prevalent eczema (OR=1.15 [95%CI 0.98-1.36]), both non-atopic (OR=1.39 [1.02-1.90]) and atopic eczema (OR=1.26 [1.00-1.59]). These associations were not seen in females (P for interaction=0.08, <0.01). For both sexes, a 1.6 μg/m3 increase in PM2.5 exposure at follow-up was associated with increased odds of aeroallergen sensitisation (OR=1.15 [1.03-1.30]). Conclusion: Increased exposure to residential ambient air pollutants was associated with an increased risk of eczema, only in males, and aeroallergen sensitisation in both genders.

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Nonatopic eczema in elderly women: Effect of air pollution and genes

Cited by 40 publications

References 49 publications

The “envirome” and what the practitioner needs to know about it

The “envirome” and what the practitioner needs to know about it

Atopic Dermatitis in Older Adults: A Review of Treatment Options

Association between ambient air pollution and development and persistence of atopic and non-atopic eczema in a cohort of adults

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