The “envirome” and what the practitioner needs to know about it

Peden, David B.

doi:10.1016/j.anai.2019.09.014

Cited by 18 publications

(10 citation statements)

References 66 publications

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“…Our results also showed that asthma cases had significantly higher parental smoke exposure and smoking history. This finding once again demonstrated to us the effect of smoke exposure on the pathogenesis of asthma as reported previously [ 39 ].…”

Section: Discussionsupporting

confidence: 89%

Evaluation of blood and tooth element status in asthma cases: a preliminary case–control study

Yalçin

Emiralioğlu

2021

BMC Pulm Med

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Background Asthma is a common respiratory disorder; some data were present on the correlation between increased levels of trace elements and the risk of asthma development. It was aimed to evaluate the levels of 13 selected blood and tooth elements (magnesium, phosphorus, calcium, chromium, manganese, iron, copper, zinc, strontium, molybdenum, cadmium, lead, mercury) in a well-controlled asthma group and the control group. Methods During the study period, 17 asthma patients and 26 age and gender-matched healthy children donated shed deciduous teeth having neither decay nor filling and enrolled for the study. The element levels in blood and teeth matrixes were analyzed with inductively coupled plasma mass spectrometry. Differences in blood and tooth elements in groups were evaluated with generalized linear models after adjusting confounding factors. Results After adjusting the child’s “z scores of body mass index for age”, history of iron deficiency anemia, and status of parental smoking, the generalized linear model revealed significantly lower tooth magnesium levels, lower blood zinc levels, and lower blood zinc/copper ratio in the asthma group than the control group (p = 0.042, p = 0.034, p = 0.002, respectively). Other studied elements for tooth and blood matrixes were similar in groups. Conclusion Our study revealed some differences in tooth and blood element levels in the asthma group. Further studies on zinc and magnesium levels of severe asthma cases are necessary for the interpretation of the results.

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Section: Discussionsupporting

confidence: 89%

Evaluation of blood and tooth element status in asthma cases: a preliminary case–control study

Yalçin

Emiralioğlu

2021

BMC Pulm Med

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“…The immediate consequences (fatalities, emergency room visits, and stress caused by the destruction of homes, livelihoods, and mass evacuations) are readily acknowledged, but little attention has been paid to the less obvious medium-and long-term health effects of wildfires. Of great additional concern is how vulnerable populations, firefighters, pregnant women, children, the elderly, and those from marginalized communities (due to ethnic or socioeconomic status), become at high risk of developing disease upon repeated wildfire exposures [13][14][15]. This review is aimed at discussing these issues in light of currently available information.…”

Section: Introductionmentioning

confidence: 99%

“Air That Once Was Breath” Part 2: Wildfire Smoke and Airway Disease – “Climate Change, Allergy and Immunology” Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023

Bowman,

Schmidt,

Sanghar

et al. 2024

Int Arch Allergy Immunol

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Background: Population growth and climate change have led to more frequent and larger wildfires, increasing the exposure of individuals to wildfire smoke. Notably, asthma exacerbations and allergic airway sensitization are prominent outcomes of such exposure. Summary: Key research questions relate to determining the precise impact on individuals with asthma, including the severity, duration, and long-term consequences of exacerbations. Identifying specific risk factors contributing to vulnerability, such as age, genetics, comorbidities, or environmental factors, is crucial. Additionally, reliable biomarkers for predicting severe exacerbations need exploration. Understanding the long-term health effects of repeated wildfire smoke exposures in individuals with asthma and addressing healthcare disparities are important research areas. Key Messages: This review discusses the need for comprehensive research efforts to better grasp wildfire smoke-induced respiratory health, particularly in vulnerable populations such as farmworkers, firefighters, pregnant women, children, the elderly, and marginalized communities. Effective mitigation would require addressing the current limitations we face by supporting research aimed at a better understanding of wildfire smoke-induced airway disease.

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“…Ground-level (tropospheric) O 3 is generated by the action of sunlight's UV rays from precursors (mostly air pollutants containing hydrocarbons, volatile organic compounds [VOC] and nitrogen oxides emitted during fossil fuel combustion). In cities with high O 3 levels people had an over 30% increased risk of dying from lung disease (117) and children playing outdoor sports had a three times greater chance of developing asthma (118,119).…”

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confidence: 99%

Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma

2021

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Despite recent advances in using biologicals that target Th2 pathways, glucocorticoids form the mainstay of asthma treatment. Asthma morbidity and mortality remain high due to the wide variability of treatment responsiveness and complex clinical phenotypes driven by distinct underlying mechanisms. Emerging evidence suggests that inhalation of the toxic air pollutant, ozone, worsens asthma by impairing glucocorticoid responsiveness. This review discusses the role of oxidative stress in glucocorticoid resistance in asthma. The underlying mechanisms point to a central role of oxidative stress pathways. The primary data source for this review consisted of peer-reviewed publications on the impact of ozone on airway inflammation and glucocorticoid responsiveness indexed in PubMed. Our main search strategy focused on cross-referencing “asthma and glucocorticoid resistance” against “ozone, oxidative stress, alarmins, innate lymphoid, NK and γδ T cells, dendritic cells and alveolar type II epithelial cells, glucocorticoid receptor and transcription factors”. Recent work was placed in the context from articles in the last 10 years and older seminal research papers and comprehensive reviews. We excluded papers that did not focus on respiratory injury in the setting of oxidative stress. The pathways discussed here have however wide clinical implications to pathologies associated with inflammation and oxidative stress and in which glucocorticoid treatment is essential.

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The “envirome” and what the practitioner needs to know about it

Cited by 18 publications

References 66 publications

Evaluation of blood and tooth element status in asthma cases: a preliminary case–control study

Evaluation of blood and tooth element status in asthma cases: a preliminary case–control study

“Air That Once Was Breath” Part 2: Wildfire Smoke and Airway Disease – “Climate Change, Allergy and Immunology” Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023

Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma

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