Nonallergic rhinitis: Common problem, chronic symptoms

Schroer, Brian; Pien, Lily

doi:10.3949/ccjm.79a11099

Cited by 33 publications

(19 citation statements)

References 24 publications

(25 reference statements)

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“…46,47 However, there is currently no consensus on the eosinophilic threshold required for diagnosis, because any amount from greater than 5% to greater than 20% has been reported to indicate this condition. 2,8,48 However, recent research scrutinizing NARES mechanics has raised questions regarding whether this is a distinct condition or whether it mostly overlaps with other conditions. 40 The value of this histologic-based classification is further reduced because the methodologies used to obtain nasal cytology by swabbing or scraping the inferior turbinate or nasal lavage are variable and burdensome, making it impractical to routinely perform in the clinical setting.…”

Section: Nonallergic Rhinitismentioning

confidence: 99%

“…3,67,68 Further endotypes of IR could be defined by the trigger type; for example, irritantsensitive IR. 8 An irritant-induced umbrella phenotype that includes not only IR but other entities such as occupational rhinitis subphenotypes has been proposed (see Fig. 2).…”

Section: Idiopathic Rhinitismentioning

confidence: 99%

“…The local inflammatory endotype commonly occurs after ingestion of aspirin and other nonsteroidal antiinflammatory drugs. 8,79 Although various pathogenic mechanisms have been proposed, it is thought that the inhibition of cyclooxygenase-1 shifts the metabolism of arachidonic acid to the lipooxygenase pathway, resulting in decreased production of prostaglandin E2 and increased cysteinyl leukotriene release (ie, leucotriene C4) precipitating local inflammation. 79 The neurogenic endotype of drug-induced rhinitis can occur with sympatholytic drugs such as alpha-adrenergic and beta-adrenergic antagonists, including clonidine, guanethidine, doxazocin, and methyldopa.…”

Section: Drug-induced Rhinitismentioning

confidence: 99%

“…For instance, from a clinical perspective, patients are classified as blockers, with nasal congestion as the prominent symptom, and runners, with rhinorrhea being predominant. Also, rhinitis caused by mechanical/structural abnormalities is included in the NAR subgroup by some investigators 7,8 and excluded by others. 9 Furthermore, occupational rhinitis can be either allergic or nonallergic, blurring the boundaries between the 3 widely accepted categories.…”

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confidence: 99%

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Rhinitis Subtypes, Endotypes, and Definitions

Papadopoulos

Guibas

2016

Immunology and Allergy Clinics of North America

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Rhinitis is often seen as posing a small burden. However, rhinitis is a complex disease that is underpinned by a plethora of different mechanisms and causes. Rhinitis is frequently associated with other comorbid conditions but, by itself, is a source of considerable morbidity for patients and creates a significant financial burden on health systems worldwide. This article approaches this condition from both a phenotypic and mechanistic standpoint, focusing on the complexity of characterizing these subtypes. Developing a clearer demarcation of the currently obscure rhinitis phenotypes and endotypes will substantially improve their future prevention and treatment.

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Section: Nonallergic Rhinitismentioning

confidence: 99%

Section: Idiopathic Rhinitismentioning

confidence: 99%

Section: Drug-induced Rhinitismentioning

confidence: 99%

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confidence: 99%

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Rhinitis Subtypes, Endotypes, and Definitions

Papadopoulos

Guibas

2016

Immunology and Allergy Clinics of North America

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“…В последнее время для улучшения эрек-тильной функции активно применяют силденафил (Виагра). Правильно собранный анамнез в этом случае может помочь устранить причину ринита [19]. 6.…”

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Analysis of Current Therapeutic Approaches to Chronic Rhinitis According to the Polyclinic Data of Ambulatory Service of Moscow

Савлевич¹,

Козлов²,

Жарких³

et al. 2017

Medicinskij sovet

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Т ермин «ринит» применим для большой гетеро-генной группы заболеваний с различной этио-логией и патофизиологическими механизмами развития, которые объединены общей клинической кар-тиной в виде 4 основных симптомов: заложенности носа, выделений из носа различного характера, чиханья и зуда в носу. При этом комбинации симптомов могут быть раз-личными, могут дополняться другими болезненными ощу-щениями в виде нарушения обоняния, образования корок в носу и т. д. В настоящее время одним из основных параметров оценки состояния пациента и эффективности проводимой терапии является показатель качества жизни, связанного со здоровьем (Health-related quality of life), который, с точки зрения больного, имеет большее значе-ние, чем количественные показатели лабораторных ана-лизов или других объективных методов исследования. Это многомерное понятие, дифференцированно опреде-ляющее влияние конкретного заболевания и проводи-мых лечебных мероприятий на психологическое, эмоци-ональное и физическое состояние человека [1].По данным проведенных исследований, которые чаще всего выполнены при аллергическом рините (АР), практи- terms «Hypertrophic rhinitis» and «Vasomotor rhinitis» were used for non-allergic rhinitis, while code J30.4 and the terms «Allergic rhinitis» or «Vasomotor-allergic rhinitis» were used for allergic genesis. The diagnosis «Intermittent AR» was indicated once, and severity was mentioned only in 2 patients. In AR group (216 people), a comprehensive study was performed in 6.5% of cases, the diagnosis was established empirically in 52.7% of cases. Antihistamines were prescribed in 27.3% of cases, intranasal corticosteroids in 77.8%, montelukast in 9.7%, allergen-specific immunotherapy was performed in 1.9%. In non-allergic rhinitis (563 patients), 77.4% intranasal received corticosteroids, 7.5% received antihistamines, 3.7% -montelukast, 4.8% underwent surgical treatment. In both groups, original methods of therapy in the form of local antibiotics, homeopathic drugs, bacterial lysates were reported. In the AR group, a violation of the step-by-step therapy regimen was identified.

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