Capsaicin for non-allergic rhinitis

Gevorgyan, Artur; Segboer, Christine; Gorissen, Rob; Drunen, Cornelis M. van; Fokkens, Wytske J.

doi:10.1002/14651858.cd010591

Cited by 12 publications

(16 citation statements)

References 25 publications

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“…In this study, capsaicin showed promising results in treatment of nonallergic rhinitis as demonstrated in several RCTs and supported via systematic review . Shortcomings of the capsaicin literature were the relatively few studies available and the relatively small samples in the pertinent studies.…”

Section: Discussionsupporting

confidence: 61%

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Gettelfinger

Ting

et al. 2020

Int Forum Allergy Rhinol

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Background Sinusitis and rhinitis are common diseases for which patients seek medical attention. Alternative therapies constitute a multibillion‐dollar industry despite poorly established efficacy and safety profiles. This study was designed to identify and grade the evidence for alternative therapies purported to treat sinusitis and rhinitis. Methods A modified Delphi method was used to establish a consensus opinion among rhinology experts of the current evidence for efficacy, potential harm, and future research needs for alternative therapies in sinusitis and rhinitis. Following the initial Delphi round of discussion, a Google search query was performed to identify topics and review online reports of benefit. Subsequent rounds established search criteria and inclusion/exclusion criteria for a systematic literature review utilizing PubMed, EMBASE, and Cochrane databases. Centre for Evidence‐Based Medicine (CEBM) and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) criteria were used to assess levels of evidence and recommendations. Final Delphi rounds were performed until consensus opinions could be reached. Results Over 60 potential alternative therapies for sinusitis and rhinitis were identified. The literature review included 2066 titles with 220 full‐text articles found to be relevant. Most of the therapies had little to no scientific evidence; however, acupuncture, capsaicin, bromelain, and butterbur extract currently have low to moderate‐high GRADE rating. Allergic rhinitis was the most common disease studied. Conclusion Some alternative therapies show promise as potential treatments for sinusitis and rhinitis, mostly compared to placebo. Comparisons to traditional therapies are lacking. For other alternative therapies, many websites included unsubstantiated claims of benefit and ignored potential side effects for which patients should be warned appropriately.

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Section: Discussionsupporting

confidence: 61%

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Gettelfinger

Ting

et al. 2020

Int Forum Allergy Rhinol

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“…7 We found an overexpression of TRPV1 in patients with IR compared with healthy control (HC) subjects, and our data on the combined reduction of nasal symptoms, NHR, and expression of SP, PGP9.5, TRPV1, and TRPM8 by nasal capsaicin treatment strongly suggests the involvement of the TRPV1-SP nociceptive signaling pathway in patients with IR. 7 Although capsaicin, the pungent agent in chili peppers, is recommended for the treatment of IR, 8 large-scale, double-blind, placebo-controlled trials have not been performed. Furthermore, little is known about prognostic factors influencing the therapeutic outcome of capsaicin nasal treatment.…”

Section: Abbreviations Usedmentioning

confidence: 99%

Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment

Gerven

Alpízar

Steelant

et al. 2017

Journal of Allergy and Clinical Immunology

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The lower threshold for AITC based on NMPs in patients with IR compared with HC subjects and the increased threshold for AITC after capsaicin treatment in patients with IR demonstrate the crucial role of TRPA1 and TRPV1 in IR pathophysiology. The strong correlation between the increase in AITC threshold in patients with IR and symptom reduction after capsaicin treatment demonstrates the clinical relevance of these findings.

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“…On the other hand, a recent study of patients with nonallergic rhinitis revealed overexpression of TRPV1 in the nasal mucosa and increased substance P levels in nasal secretions at baseline, with reduced symptoms and reduced levels of nasal hyperreactivity following topical capsaicin treatment [19]. The authors suggest that the ablation of the TRPV1-substance P nociceptive signaling pathway [51][52][53]. Systemic neuromodulating agents may constitute another approach to the management of neuropathic symptoms in allergic disease.…”

Section: Neurogenic Mechanisms Of Ac: Implications For Management Appmentioning

confidence: 99%

Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis

Kuruvilla¹,

Kalangara²,

Lee³

2019

J Investig Allergol Clin Immunol

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Capsaicin for non-allergic rhinitis

Cited by 12 publications

References 25 publications

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment

Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis

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