Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis

Kuruvilla, Merin; Kalangara, Jerry P.; Lee, F. Eun-Hyung

doi:10.18176/jiaci.0320

Cited by 25 publications

(23 citation statements)

References 56 publications

(60 reference statements)

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“…e condition is often classified as seasonal allergic conjunctivitis (SAC), perennial allergic conjunctivitis (PAC), atopic keratoconjunctivitis (AKC), vernal keratoconjunctivitis (VKC), and giant papillary conjunctivitis (GPC) [1,20,21]. 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC [22]. An European Academy of Allergy and Clinical Immunology (EAACI) task force suggested to include "ocular allergy" in the "ocular surface hypersensitivity disorders," dividing the different forms into IgE-mediated and non-IgE-mediated diseases [20,23].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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Allergic conjunctivitis (AC) is a common allergic disease that is often associated with the onset of rhinitis or asthma. The incidence of AC has increased significantly in recent years possibly due to air pollution and climate warming. AC seriously affects patients’ quality of life and work efficiency. Th (T-helper) 2 immune responses and type I hypersensitivity reactions are generally considered the basis of occurrence of AC. It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. However, the role of Th17 and IL-17 in AC is unclear. This paper will focus on how T-helper 17 cells and interleukin-17 are activated in the Th2 immune response of allergic conjunctivitis and how they promote the Th2 immune response of AC.

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Section: Introductionmentioning

confidence: 99%

“…So, they have a significant impact on the quality of patient's life and affect social economy [30]. Although VKC and AKC account for only 2% of ocular allergy cases, they have a greater impact on life [22]. Unlike SAC and PAC, VKC and AKC appear as corneal involvement.…”

Section: Introductionmentioning

confidence: 99%

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

Meng

Shi

Zhang

et al. 2020

Journal of Ophthalmology

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“…10,11 Additionally, similar symptoms have been observed in patients with allergic conjunctivitis and blepharoconjunctivitis. 12,13 Furthermore, wearing glasses might prevent respiratory droplet transmission, but might also cause more contact with the face. Th ere is a study…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Enfeksiyonlu Hastalarda Eşlik Eden Oküler Hastalıklar

Atum

Boz

Çinar

et al. 2021

Sakarya Medical Journal

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Objective To investigate the presence of chronic ocular diseases in patients who had a real-time reverse transcription-polymerase chain reaction (rRT-PCR) test of oropharyngeal/ nasopharyngeal swabs for SARS-CoV-2 virus. Materials and Methods A retrospective chart review was conducted to determine all hospitalized patients who had a positive rRT-PCR test for SARS-CoV-2 virus. From these patients, who applied to eye polyclinics in the last one year were included and the diagnosis was investigated. Results This study investigated 1120 patients with a positive rRT-PCR test. Of these patients, 178 (15.8%) had applied to eye clinics previously. The most common diseases were refractive errors, dry eye syndrome, blepharoconjunctivitis, and allergic conjunctivitis. Conclusion The rate of concomitant ocular diseases in patients with confirmed SARS-CoV-2 was 15.8%. Avoiding touching the face and eyes and hand hygiene were the main prevention ways from SARS-CoV-2 infection. Concomitant ocular diseases might increase the risk of contact transmission routes.

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“…Recently, it was suggested that TRPA1 might also be involved in allergic conjunctivitis [75]. Compared to wild-type animals, TRPA1 deficient mice show fewer symptoms in a model of allergic conjunctivitis [76].…”

Section: Potential Disease—modification Through Trpa1 Modulationmentioning

confidence: 99%

Non-Analgesic Symptomatic or Disease—Modifying Potential of TRPA1

Heber

Fischer

2019

Medical Sciences

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TRPA1, a versatile ion channel of the Transient Receptor Potential (TRP) channel family, detects a large variety of chemicals and can contribute to signal processing of other stimuli, e.g., due to its sensitivity to cytosolic calcium elevation or phosphoinositolphosphate modulation. At first, TRPA1 was found on sensory neurons, where it can act as a sensor for potential or actual tissue damage that ultimately may elicit pain or itch as warning symptoms. This review provides an update regarding the analgesic and antipruritic potential of TRPA1 modulation and the respective clinical trials. Furthermore, TRPA1 has been found in an increasing amount of other cell types. Therefore, the main focus of the review is to discuss the non-analgesic and particularly the disease-modifying potential of TRPA1. This includes diseases of the respiratory system, cancer, ischemia, allergy, diabetes, and the gastrointestinal system. The involvement of TRPA1 in the respective pathophysiological cascades is so far mainly based on pre-clinical data.

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Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis

Cited by 25 publications

References 56 publications

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis

SARS-CoV-2 Enfeksiyonlu Hastalarda Eşlik Eden Oküler Hastalıklar

Non-Analgesic Symptomatic or Disease—Modifying Potential of TRPA1

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