Nonalcoholic Fatty Liver Disease

Paredes, Angelo H.; Torres, Dawn M.; Harrison, Stephen A.

doi:10.1016/j.cld.2012.03.005

Cited by 59 publications

(57 citation statements)

References 158 publications

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“…Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver impairment in developed countries and includes a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and liver fibrosis [1,2]. Although NAFLD is a general benign disease, almost 10-20% of NAFLD patients have NASH which will develop into liver fibrosis and increase the risk of liver carcinoma [3].…”

Section: Introductionmentioning

confidence: 99%

Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice

Xu¹,

Tao²,

Zhang³

et al. 2013

ABBS

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Section: Introductionmentioning

confidence: 99%

Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice

Xu¹,

Tao²,

Zhang³

et al. 2013

ABBS

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“…The strong association of this disease with obesity, central fat distribution, DM2, dyslipidemia, hypertension and atherosclerotic disease, supports the hypothesis that NAFLD may represent a further condition of metabolic syndrome 21 . In a study with 1022 Korean trying to correlate metabolic syndrome with the severity of hepatic steatosis (graded through sonographic criteria), it was found that as the degree of steatosis increased, there was a raise in weight, IR (measured by HOMA), serum levels of liver enzymes and also in serum cholesterol and triglycerides 22 . According to some studies evaluating the epidemiology of NAFLD, this condition is more common in men and its incidence increases with age 3,23 .…”

Section: Comparison Between Groups 1 Andmentioning

confidence: 99%

Relação entre o estado nutricional de vitamina a e a regressão da esteatose hepática após gastroplastia em Y- de- Roux para tratamento da obesidade classe III

Silva

Manso²,

Silva

et al. 2012

ABCD, arq. bras. cir. dig.

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-Background -Vitamin A participates in several essentials functions in the human body and their serum concentrations may be decreased in non-transmissible diseases. Aim -To assess the relationship of the nutritional status of Vitamin A through the serum concentrations of retinol and beta carotene, with regression of hepatic steatosis in individuals who undergone Roux-en-Y gastric bypass surgery for treatment of class III obesity. Methods -Were included 30 individuals, male and female, submitted to Roux-en-Y gastric bypass for treatment of class III obesity, who were diagnosed through an abdominal ultrasonography as presenting hepatic steatosis. From the result of an ultrasonography screened six months after the surgical procedure those subjects were divided into two groups: group 1 -patients with steatosis detected in the ultrasonography (16 subjects) and group 2 -patients without steatosis detected in the ultrasonography (14 subjects). Before and six months after the surgery, were carried out anthropometrical analyses and biochemical exams (basal insulin, glicemy, Homeostasis Model Assessment Index (HOMA IR), cholesterol, HDL, LDL, triglycerides, AST, ALT, Gamma-GT, albumin, total bilirubin, retinol, and beta carotene. Results -The individuals presented an average weight loss of 35.05 + 10.47 (p<0.01) and a decrease in the Body Mass Index (BMI) of 11.6 + 4.99 Kg/m² (p<0.01). After six months, all the biochemical exams presented a significant decrease in their basal concentrations (p<0.05). In the post-operative period the group 2 (without steatosis) presented concentrations significantly lower (p<0.05) in the following variables: weight, BMI, AST, ALT, Gamma-GT, HOMA IR, basal insulin. The albumin serum concentrations presented close average values, with no significant difference in the two periods evaluated. In the assessment of retinol and beta carotene, higher serum concentrations and a small decrease in relation to the concentrations of the pre-operative period in the group without steatosis were observed, however, no statistical difference was found. Conclusion -An adequate nutritional status of vitamin A might contribute in the improvement of the hepatic esteatosis after Roux-en-Y gastric bypass for class III obesity treatment. ABCDDV/879RESUMO -Racional -A vitamina A participa de várias funções primordiais no organismo humano e as suas concentrações séricas podem estar diminuídas nas doenças crônicas não transmissíveis. Objetivo -Avaliar a relação entre o estado nutricional da vitamina A, e a regressão da esteatose hepática em indivíduos submetidos à gastroplastia em Y-de-Roux para tratamento da obesidade classe III.

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“…NAFLD is characterized by deposition of hepatic fat with or without other pathologic changes on the liver biopsy. [1,2] By definition, NAFLD excludes secondary causes of fatty liver including excessive alcohol use, medications, or hereditary disorders such as Wilson's disease and lipodystrophy [1][2][3]. NAFLD has been considered the most common cause of liver enzyme elevation and is rapidly becoming one of the most common liver diseases in the Western countries [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…[1,2] By definition, NAFLD excludes secondary causes of fatty liver including excessive alcohol use, medications, or hereditary disorders such as Wilson's disease and lipodystrophy [1][2][3]. NAFLD has been considered the most common cause of liver enzyme elevation and is rapidly becoming one of the most common liver diseases in the Western countries [1][2][3]. Further, NAFLD is now the second indication for liver transplantation and is associated with hepatocellular carcinoma, a deadly cancer which is currently the fifth leading cause of death in the world [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Hepatic steatosis alone (NAFL) is defined as fatty infiltration of the liver without evidence of inflammation, hepatocyte damage or fibrosis [1][2][3][4]. Non-alcoholic steatohepatitis (NASH), on the other hand, is characterized by hepatic steatosis with inflammation and hepatocellular ballooning or other evidence of hepatocyte injury or fibrosis [6].…”

Section: Introductionmentioning

confidence: 99%

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Economic and Quality-of-Life Implications of Non-Alcoholic Fatty Liver Disease

Younossi

Henry

2015

PharmacoEconomics

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Non-alcoholic fatty liver disease (NAFLD) is a very common chronic liver disease worldwide, is on the rise following the trend of increasing prevalence of obesity, is the second most common indication for liver transplantation, and is an important cause for hepatocellular carcinoma. Despite the increasing recognition of NAFLD as an important chronic liver disease, little has been published on the economic and health-related quality of life (HR-QOL) impact of NAFLD. We reviewed the current literature related to the economics and HR-QOL of NAFLD and found that increased costs and decreased HR-QOL were associated with NAFLD.

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Nonalcoholic Fatty Liver Disease

Cited by 59 publications

References 158 publications

Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice

Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice

Relação entre o estado nutricional de vitamina a e a regressão da esteatose hepática após gastroplastia em Y- de- Roux para tratamento da obesidade classe III

Economic and Quality-of-Life Implications of Non-Alcoholic Fatty Liver Disease

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