Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis

Brea, Ángel; Mosquera, Daniel; Martín, E; Arizti, Ana; Cordero, José Luis; Ros, Emilio

doi:10.1161/01.atv.0000160613.57985.18

Cited by 346 publications

(269 citation statements)

References 41 publications

Supporting

Mentioning

238

Contrasting

Unclassified

Order By: Relevance

“…This finding clearly indicated that subjects with a high-normal ALT might be susceptible to carotid atherosclerosis. There are many cross-sectional [13][14][15][16] and prospective [9,17,18] studies on the association between NAFLD and intermediate markers of cardiovascular disease or clinical outcomes. These studies have reported that ultrasounddiagnosed liver steatosis or raised serum concentrations of liver enzymes predict an increased risk of cardiovascular disease, independent of several established risk factors.…”

Section: Discussionmentioning

confidence: 99%

Normal range of alanine aminotransferase concentration is associated with carotid atherosclerosis

Kim¹,

Kim²,

Kim³

et al. 2010

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Normal range of alanine aminotransferase concentration is associated with carotid atherosclerosis

Kim¹,

Kim²,

Kim³

et al. 2010

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

“…The main cross-sectional [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] and prospective [11,[32][33][34][35][36][37][38][39][40][41][42][43] studies on the association between NAFLD and intermediate markers of CVDor clinical outcomes are shown in Tables 1 and 2 of the Electronic supplementary material. NAFLD, endothelial dysfunction, early carotid atherosclerosis and left ventricular dysfunction NAFLD is associated with circulatory endothelial dysfunction [16,17], a marker of early atherosclerosis. Compared with non-steatotic controls, non-diabetic patients with NAFLD show a significant decrease in brachial artery flow-mediated vasodilation, which is related to the severity of NAFLD histology, independently of age, sex, BMI and HOMA-IR [16].…”

Section: Evidence Linking Nafld With Cvdmentioning

confidence: 99%

“…Carotid artery intima-media thickness (IMT), another marker of early atherosclerosis, is also markedly increased in patients with NAFLD patients compared with that in age-, sex-and BMI-matched healthy controls [20][21][22][23][24][25], and NAFLD histology predicts carotid IMT independently of traditional risk factors, HOMA-IR and features of the metabolic syndrome [24]. Similarly, patients with NAFLD, also in the absence of obesity, hypertension and diabetes, exhibit echocardiographic features of early left ventricular dysfunction [18] and impaired energy metabolism as measured by cardiac 31 P magnetic resonance spectroscopy [19].…”

Section: Evidence Linking Nafld With Cvdmentioning

confidence: 99%

Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?

2008

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD), comprising a spectrum of conditions ranging from pure steatosis to steatohepatitis and cirrhosis, has reached epidemic proportions and represents the most common cause of chronic liver disease in the community. The prevalence of NAFLD has been estimated to be between 20% and 30% in the general population, but this value is much higher (∼70-80%) in type 2 diabetic patients, who are also at higher risk of developing advanced fibrosis and cirrhosis. Increasing recognition of the importance of NAFLD and its strong relationship with the metabolic syndrome has stimulated an interest in the possible role of NAFLD in the development of cardiovascular disease (CVD). Several epidemiological studies indicate that NAFLD, especially in its more severe forms, is linked to an increased risk of CVD, independently of underlying cardiometabolic risk factors. This suggests that NAFLD is not merely a marker of CVD, but may also be actively involved in its pathogenesis. The possible molecular mediators linking NAFLD and CVD include the release of pro-atherogenic factors from the liver (C-reactive protein, fibrinogen, plasminogen activator inhibitor-1 and other inflammatory cytokines) as well as the contribution of NAFLD per se to whole-body insulin resistance and atherogenic dyslipidemia, in turn favouring CVD progression. The clinical impact of NAFLD on CVD risk deserves particular attention in view of the implications for screening and surveillance strategies in the growing number of patients with NAFLD.

show abstract

“…Indeed, in the last 5 years NAFLD has emerged as an independent risk factor for CVD. Several studies have observed increased carotid intima-media thickness and carotid plaques in patients with NAFLD, including children (39,(107)(108)(109)(110)(111) . Although there has been some conflicting work (112) , a systematic review has found that carotid plaques are two to three times more likely to be observed in patients with NAFLD and intima-media thickness is strongly associated with NAFLD (113) .…”

Section: Genetic and Environmental Factors Associated With Non-alcohomentioning

confidence: 99%

Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome

2010

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease in both adults and children worldwide. As a disease spectrum, NAFLD may progress from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. An estimated 20-35% of the general population has steatosis, 10 % of whom will develop the more progressive non-alcoholic steatohepatitis associated with markedly increased risk of cardiovascular-and liver-related mortality. Development of NAFLD is strongly linked to components of the metabolic syndrome including obesity, insulin resistance, dyslipidaemia and type 2 diabetes. The recognition that NAFLD is an independent risk factor for CVD is a major public health concern. There is a great need for a sensitive non-invasive test for the early detection and assessment of the stage of NAFLD that could also be used to monitor response to treatment. The cellular and molecular aetiology of NAFLD is multi-factorial; genetic polymorphisms influencing NAFLD have been identified and nutrition is a modifiable environmental factor influencing NAFLD progression. Weight loss through diet and exercise is the primary recommendation in the clinical management of NAFLD. The application of systems biology to the identification of NAFLD biomarkers and factors involved in NAFLD progression is an area of promising research.

show abstract

Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis

Abstract: Objective-Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia. We examined whether NAFLD was associated with atherosclerosis, as measured by ultrasound in the carotid arteries. Methods and Results-Carotid

Cited by 346 publications

References 41 publications

Normal range of alanine aminotransferase concentration is associated with carotid atherosclerosis

Normal range of alanine aminotransferase concentration is associated with carotid atherosclerosis

Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?

Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome

Contact Info

Product

Resources

About