Nonalcoholic Fatty Liver Disease in Children: Beyond Metabolic Syndrome

Hays, Stacia M.; McGinnis, Cheryl

doi:10.1016/j.nurpra.2018.08.034

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Prevalence of NAFLD is especially high in young people who have obesity such that 22.5%-52.8% of children with obesity have NAFLD compared to 2.6% of all children (Anderson et al 2015). Child obesity has the highest risk in the development of NAFLD during childhood (Hays & McGinnis 2018). A longitudinal study of participants ages 3-18 years were followed for 31 years, and saw that child OW/OB was associated with increased risk for adult NAFLD (Cuthbertson et al 2018).…”

Section: Hypertension-hypertensionmentioning

confidence: 99%

Prevention and Management of Childhood Obesity and Its Psychological and Health Comorbidities

Smith

Kobayashi

2020

Annu. Rev. Clin. Psychol.

203

126

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Childhood obesity has become a global pandemic in developed countries, leading to a host of medical conditions that contribute to increased morbidity and premature death. The causes of obesity in childhood and adolescence are complex and multifaceted, presenting researchers and clinicians with myriad challenges in preventing and managing the problem. This article reviews the state of the science for understanding the etiology of childhood obesity, the preventive interventions and treatment options for overweight and obesity, and the medical complications and co-occurring psychological conditions that result from excess adiposity, such as hypertension, nonalcoholic fatty liver disease, and depression. Interventions across the developmental span, varying risk levels, and service contexts (e.g.,community, school, home, health care systems) are reviewed. Future directions for research are offered with an emphasis on translational issues for taking evidence-based interventions to scale in a manner that will reduce the public health burden of the childhood obesity pandemic.

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Section: Hypertension-hypertensionmentioning

confidence: 99%

Prevention and Management of Childhood Obesity and Its Psychological and Health Comorbidities

Smith

Kobayashi

2020

Annu. Rev. Clin. Psychol.

203

126

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“…The increasingly high prevalence of paediatric obesity (body mass index [BMI] ≥ 95th percentile for age and gender) and severe obesity (BMI ≥ 120% of the 95th percentile) is a public health epidemic, and is associated with an abundance of health issues and health disparities 1‐6 . Severe paediatric obesity, often underappreciated as a distinct risk indicator, is associated with increased negative health outcomes compared to obesity, especially cardiometabolic risk factors, such as total cholesterol, systolic blood pressure, and glycated haemoglobin.…”

Section: Introductionmentioning

confidence: 99%

Parenting andsocial‐ecologicalcorrelates with children's health behaviours: A latent profile analysis

Grimm

Berkel

et al. 2020

Pediatric Obesity

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Summary Background Paediatric obesity poses dangers to children's short and long‐term health. Multi‐level ecological models posit how children's health behaviours are influenced by interpersonal relationships. Objectives To identify profiles of individual and interpersonal health behaviours and parenting skills among caregivers and their children with elevated BMI. Methods Participants were 240 children (63.7% Latino) ages 5 to 12 years with body mass index ≥85th percentile and their caregivers in a paediatric weight management intervention trial. A latent profile analysis was used to identify profiles among caregiver report of parenting skills; child physical activity, eating behaviours, and food and beverage choices; family mealtime, media and sleep routines; and parent health behaviours, and associations with food and housing insecurity. Results A three‐class model was chosen based on conceptual interpretation and model fit. Profiles were differentiated by parenting skills, child food choices, child physical activity habits, family mealtime, media, and sleep routines, and parent health behaviours. Food and housing insecurity were associated with class membership while child and caregiver anthropometrics were not. Conclusions Distinct profiles existed among this low‐income, racially/ethnically diverse sample of children with elevated BMI. Such findings emphasize the importance of assessing individual and interpersonal influences and contextual factors on childhood obesity.

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“…These techniques are sensitive to advanced fibrosis, but not to early and middle stage fibrosis. Liver biopsy still is the gold standard for diagnosis [9], however, histological assessment of fibrosis is labor‐intensive and time‐consuming. In addition, the pathological evaluation of tumor cells and collagen fibers cannot be carried out in the same field of view, and their relative position information may be ignored.…”

Section: Introductionmentioning

confidence: 99%

Detection of fibrotic changes in the progression of liver diseases by label‐free multiphoton imaging

Huang

Lian

Qiu

et al. 2023

Journal of Biophotonics

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Collagen fibers play an important role in the progression of liver diseases. The formation and progression of liver fibrosis is a dynamic pathological process accompanied by morphological changes in collagen fibers. In this study, we used multiphoton microscopy for label‐free imaging of liver tissues, allowing direct detection of various components including collagen fibers, tumors, blood vessels, and lymphocytes. Then, we developed a deep learning classification model to automatically identify tumor regions, and the accuracy reaches 0.998. We introduced an automated image processing method to extract eight collagen morphological features from various stages of liver diseases. Statistical analysis showed significant differences between them, indicating the potential use of these quantitative features for monitoring fibrotic changes during the progression of liver diseases. Therefore, multiphoton imaging combined with automatic image processing method would hold a promising future in rapid and label‐free diagnosis of liver diseases.

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Nonalcoholic Fatty Liver Disease in Children: Beyond Metabolic Syndrome

Cited by 4 publications

References 11 publications

Prevention and Management of Childhood Obesity and Its Psychological and Health Comorbidities

Prevention and Management of Childhood Obesity and Its Psychological and Health Comorbidities

Parenting andsocial‐ecologicalcorrelates with children's health behaviours: A latent profile analysis

Detection of fibrotic changes in the progression of liver diseases by label‐free multiphoton imaging

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