Nonalcoholic fatty liver disease and the epidemic of obesity.

Collantes, Rochelle; Ong, Janus P.; Younossi, Zobair M.

doi:10.3949/ccjm.71.8.657

Cited by 42 publications

(49 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To further clarify a possible positive association, between workers' PFOA concentrations and serum triglyceride levels, adjustment for shift work becomes a methodological necessity for subsequent occupational research analyses. Although hepatic enzymes, in particular GGT, AST and ALT are known to be elevated with heavy alcohol consumption, these liver enzymes can also be elevated due to obesity and dyslipidemia (Collantes et al 2004;Mofrad and Sanyal 2003;Ruhl and Everhart 2003) as non-alcoholic fatty liver disease has substantially increased in prevalence in the US population, as indicated by the third National Health and Nutrition Examination Survey (NHANES) (Clark et al 2003). Measured hepatic clinical chemistry enzymes in the present study were not consistently associated with employees' serum PFOA concentrations adjusted for age, alcohol, and either BMI or serum triglycerides.…”

Section: Discussionmentioning

confidence: 99%

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

Olsen

Zobel

2007

Int Arch Occup Environ Health

251

178

View full text Add to dashboard Cite

Objectives Perfluorooctanoic acid (PFOA) results in peroxisome proliferator mediated effects in rats and mice resulting in hypolipidemia but not in monkeys. Counterintuitive modestly positive associations between PFOA and cholesterol levels in production workers have been inconsistently reported. The purpose of this assessment was to examine this association in male workers who manufactured or used PFOA at three facilities. Methods Subjects were male employee voluntary participants of a fluorochemical medical surveillance program who provided blood samples for serum measurement of PFOA (perfluorooctanoate) and various lipid, hepatic, and thyroid parameters. Statistical analyses included multiple and logistic regression and analysis of covariance. Results A total of 506 employees, who did not take cholesterol-lowering medications (93% of all male participants), were analyzed. Serum PFOA concentrations ranged from 0.007 to 92.03 lg/ml [arithmetic mean 2.21 lg/ml (95% confidence interval 1.66-2.77), median 1.10 lg/ml]. Adjusted for age, body mass index, and alcohol usage in regression analyses, PFOA was not statistically significantly (P > 0.05) associated with total cholesterol or low-density lipoproteins (LDL). High-density lipoproteins (HDL) were significantly negatively (P < 0.01) associated with PFOA for the three facilities combined but not by individual sites, indicating the overall result was likely a consequence of residual confounding due to different demographic profiles at these sites. Serum triglycerides were significantly positively associated with PFOA but not consistently by locations. There were no statistically significant associations observed between PFOA and hepatic enzymes for the three facilities combined although some modest positive associations were observed between PFOA and hepatic enzymes at one of the three facilities. Analyses of all locations showed no associations with TSH or T4 and PFOA. A negative association was observed for free T4 and positive association for T3; however, the findings were well within these assays' normal reference ranges. Conclusion There was no evidence that employees' serum PFOA concentrations were associated with total cholesterol or LDL. A negative association with HDL was explained by demographic differences across the three locations. Several explanations are offered for the inconsistent triglyceride associations with PFOA including both methodological as well as biological possibilities.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

Olsen

Zobel

2007

Int Arch Occup Environ Health

251

178

View full text Add to dashboard Cite

show abstract

“…Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the USA and the prevalence is expected to increase (7)(8)(9)(10). NAFLD affects about 20-40% of the population of Western industrialized countries (11,12).…”

Section: Non-alcoholic Fatty Liver Disease Steatohepatitis: Prevalencementioning

confidence: 99%

Recurrence of non-viral liver disease after orthotopic liver transplantation

El-Masry

Puig

Saab

2011

Liver International

View full text Add to dashboard Cite

show abstract

“…Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a public health problem worldwide and is recognized as one of the most common forms of liver diseases (Clark et al, 2003;Kang et al, 2006) with an estimated prevalence of 10-24 percent in the general population (Angulo, 2002;Collantes et al, 2004;Bajaj et al, 2009). NAFLD encompasses a spectrum of liver disorders characterized by macrovesicular hepatic fat accumulation alone (steatosis) or accompanied by signs of hepatocyte injury, mixed inflammatory cell infiltrate and variable hepatic fibrosis (non-alcoholic steatohepatitis) (Chitturi and Farrell, 2001;Sanyal, 2002;Farrell, 2003;Farrell and Larter, 2006;Chitturi et al, 2007;Farrell et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

A case-control study on nutritional risk factors in non-alcoholic fatty liver disease in Indian population

et al. 2011

View full text Add to dashboard Cite

Background/Objectives: Non-alcoholic fatty liver disease (NAFLD) is considered an integral part of metabolic syndrome (MS). We aimed to explore the inter-relations of MS and dietary composition in subjects with and without hepatic steatosis and to identify the nutritional risk factors contributing to NAFLD. Subjects/Methods: In all 98 subjects with steatosis and 102 controls were selected for the study after screening 260 consecutive healthy individuals. Anthropometric and nutritional information, biochemical data and clinical profile were analyzed. Prevalence of MS was determined based on the consensus statement for diagnosis of MS for Asian Indians. Multiple logistic regression analysis was done to predict the dietary risk factors in NAFLD. Results: Prevalence of MS was 44.9% among NAFLD cases and 25.5% among controls (P ¼ 0.003). Subjects with NAFLD had significantly higher values of body mass index (BMI), waist circumference (WC), percent body fat, total cholesterol, triglycerides and blood pressure than controls. The total calorie intake, percent of carbohydrate and fat intake of NAFLD cases was significantly higher than controls. Multiple logistic regression analysis showed BMI (odds ratio 6.03 (95% confidence interval 3.26-11.14)), WC (5.49 (2.59-11.57)) and percent dietary fat intake (2.51 (1.99-3.31)) as independent nutritional risk factors in NAFLD. Conclusions: In this study, there is a high prevalence of MS among subjects with steatosis and metabolic disorders were closely related to NAFLD. BMI, WC and percent fat intake are independent dietary risk factors in NAFLD. Decreased nutritional intake with restricted fat may constitute an important therapy in subjects with NAFLD.

show abstract

Nonalcoholic fatty liver disease and the epidemic of obesity.

Cited by 42 publications

References 82 publications

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

Recurrence of non-viral liver disease after orthotopic liver transplantation

A case-control study on nutritional risk factors in non-alcoholic fatty liver disease in Indian population

Contact Info

Product

Resources

About