Non-toxic concentrations of cadmium accelerate subendothelial retention of atherogenic lipoproteins in humanized atherosclerosis-susceptible mice

Kijani, Siavash; Bergström, Göran; Lindbom, Malin; Levin, Malin; Barregård, Lars; Fagerberg, Björn; Fogelstrand, Per; Borén, Jan

doi:10.1016/j.atherosclerosis.2017.06.034

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, cultured bovine aortic endothelial cells showed increased numbers of heparin sulphate proteoglycan molecules after the addition of Cd chloride at 2.0 μM [64]. In apoB100 transgenic mice, intimal hyperplasia in the carotid arteries was surgically induced and a Cd‐containing gel was applied at a non‐toxic concentration [65]. In comparison with controls, gene expression analysis of the carotid arteries after 2 weeks showed that Cd treatment increased expression of genes encoding the proteoglycan perlecan and a proteoglycan modifying enzyme.…”

Section: Part Ii: Cadmium and Ascvd: Underlying Mechanismsmentioning

confidence: 99%

Review of cadmium exposure and smoking‐independent effects on atherosclerotic cardiovascular disease in the general population

Fagerberg

Barregård

2021

J Intern Med

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Part Ii: Cadmium and Ascvd: Underlying Mechanismsmentioning

confidence: 99%

Review of cadmium exposure and smoking‐independent effects on atherosclerotic cardiovascular disease in the general population

Fagerberg

Barregård

2021

J Intern Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition to increased lipid biosynthesis and its oxidation due to Cd-induced ROS overproduction [ 89 ], Cd has been shown to induce internalization of LDLs and oxLDLs into macrophages, thus promoting foam cell formation [ 95 ]. Cd exposure increased 35S-sulfate incorporation and LDL binding affinity of carotid artery proteoglycans, resulting in subendothelial retention of atherogenic lipoproteins [ 96 ]. The atherogenic effects of Cd exposure may also involve inhibition of paraoxonase 1 activity [ 97 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Martins

Ferrer

Tinkov

et al. 2023

Toxics

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is an important public health issue that affects millions of people around the world and is growing to pandemic-like proportions. This syndrome is defined by the World Health Organization (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Moreover, the etiology of MetS is multifactorial, involving many environmental factors, including toxicant exposures. Several studies have associated MetS with heavy metals exposure, which is the focus of this review. Environmental and/or occupational exposure to heavy metals are a major risk, contributing to the development of chronic diseases. Of particular note, toxic metals such as mercury, lead, and cadmium may contribute to the development of MetS by altering oxidative stress, IL-6 signaling, apoptosis, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, and other mechanisms. In this review, we discuss the known and potential roles of heavy metals in MetS etiology as well as potential targeted pathways that are associated with MetS. Furthermore, we describe how new approaches involving proteomic and transcriptome analysis, as well as bioinformatic tools, may help bring about an understanding of the involvement of heavy metals and metalloids in MetS.

show abstract

Cadmium and atherosclerosis: A review of toxicological mechanisms and a meta-analysis of epidemiologic studies

Tinkov

Filippini

Ajsuvakova

et al. 2018

Environmental Research

204

View full text Add to dashboard Cite

Non-toxic concentrations of cadmium accelerate subendothelial retention of atherogenic lipoproteins in humanized atherosclerosis-susceptible mice

Cited by 4 publications

References 0 publications

Review of cadmium exposure and smoking‐independent effects on atherosclerotic cardiovascular disease in the general population

Review of cadmium exposure and smoking‐independent effects on atherosclerotic cardiovascular disease in the general population

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Cadmium and atherosclerosis: A review of toxicological mechanisms and a meta-analysis of epidemiologic studies

Contact Info

Product

Resources

About