Non-Thermal Effects of Near-Infrared Irradiation on Melanoma

Tanaka, Yohei; Matsuo, Kiyoshi

doi:10.5772/38663

Cited by 20 publications

(46 citation statements)

References 91 publications

(113 reference statements)

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“…Therefore, various devices have been introduced to stimulate collagen production. I previously reported that near-infrared can penetrate deep into human tissue, achieve skin tightening and muscle thinning, and nonthermally induce various responses in the skin and subcutaneous tissues [4][5][6][7][8][9][10][11]. In addition, I previously reported that near-infrared or radiofrequency (RF) treatments stimulate collagen and elastin production while safely and effectively promoting long-lasting skin tightening results that decrease wrinkles and laxity [12,13].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Tanaka¹

2018

Dermatologic Surgery and Procedures

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Regardless of age, sex and skin type, skin tightening is a common procedure requested by patients seeking cosmetic treatments to improve facial contours and skin laxity. Radiofrequency has been proven to penetrate deeper than optical light sources independent of skin color and to be beneficial for skin tightening. I previously reported on the efficacy of multisource phase-controlled radiofrequency treatment and noninsulated microneedle radiofrequency applicator with fractionated pulse mode. The evaluation process was both subjective and objective; I evaluated objectively using threedimensional color schematic representation with quantitative volume measurements. These three-dimensional results showed significant improvement after the treatments. The post-treatment volume was drastically reduced as compared to the pretreatment volume. Most of the patients reported satisfaction with the improvement of skin laxity. The advantages of these multisource phase-controlled radiofrequency treatments are their long-lasting high efficacy of tightening effects, and the reduction of discomfort and side effects. These characteristics facilitate repeated treatments as well as provide safe and effective treatment of skin tightening.

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Section: Introductionmentioning

confidence: 99%

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Tanaka¹

2018

Dermatologic Surgery and Procedures

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“…NIR exhibits both wave and particle properties and appears to resonate hydrogen bonds and alpha helices, and therefore can affect the deeper tissues and induce various biological effects [10] [17]. The NIR spectrum is a result of the overtones and combination of bond stretching vibrations from O-H, C-H, and N-H groups [24].…”

Section: Discussionmentioning

confidence: 99%

“…As human skin is exposed to tremendous amounts of both solar and artificial NIR from medical devices and electrical appliances [20] [21], and most UV blocking materials cannot block NIR, blocking materials should be equipped with protection ability against NIR also [10] [17] [18].…”

Section: Introductionmentioning

confidence: 99%

Protection from Near-Infrared to Prevent Skin Damage

Tanaka¹,

Gale²

2015

OPJ

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Over half of the solar energy consists of near-infrared, and in addition to natural near-infrared, humans are increasingly exposed to artificial near-infrared from electrical appliances. Thus, we are exposed to tremendous amounts of near-infrared. Despite the wide prevalence of a variety of ultraviolet blocking materials, the necessity to protect against near-infrared has not been well recognized. To clarify the necessity to protect against near-infrared, we assessed cell viability of human fibroblast cells after water-filtered broad-spectrum near-infrared (1100 -1800 nm together with a water-filter that excludes wavelengths 1400 -1500 nm) treatment using 2 sets of transparent polycarbonate plates, one to block ultraviolet and the other to block both ultraviolet and near-infrared. The cell viability was significantly decreased after 10 rounds of near-infrared irradiation at 20 J⁄cm 2 in near-infrared treated cells without a protective polycarbonate plate and near-infrared treated cells using the polycarbonate plate to block only ultraviolet. Assuming that the cell viability of the non-irradiated control to be 100, the cell viability of the near-infrared treated cells without any protection was 0.2. The cell viability of the near-infrared treated cells with the polycarbonate plate to block only ultraviolet was 0.3, whereas both ultraviolet and nearinfrared protected cells retained a viability of 85.1. The results of this study indicate that protection from not only ultraviolet but also near-infrared should be considered to prevent skin damage.

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“…Near-infrared penetrates superficial layers and is absorbed by chromophores, such as hemoglobin and myoglobin, (21,22) which are oxygen-carrying proteins that have many a-helices. (10,23,24) The a-helices have strong amide bands in the infrared spectra that have characteristic frequencies and intensities (25) and are thought to be involved in the resonance by NIR. (10) Therefore, NIR may induce the resonance of a-helices in these oxygen-carrying proteins, resulting in protein degeneration, damage to oxygen storage and transport, and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we reported that NIR irradiation that simulates solar NIR with pre-and parallel-irradiational cooling can penetrate the skin and non-thermally affect the dermis, (1)(2)(3)(4) subdermal blood plexus, superficial skeletal muscles, (5,6) and other tissues. (7)(8)(9)(10) Furthermore, NIR induces apoptotic changes in both smooth muscle fibers of the subdermal blood plexus and skeletal muscle fibers of the panniculus carnosus in rats, which results in long-lasting vasodilation and muscle thinning. (5,6) At a wavelength of 904 nm, NIR has been shown to have antitumor activity and to increase cytomorphological changes by inducing apoptosis in neoplastic cells.…”

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confidence: 99%

Non‐thermal DNA damage of cancer cells using near‐infrared irradiation

et al. 2012

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Previously, we reported that near-infrared irradiation that simulates solar near-infrared irradiation with pre-and parallel-irradiational cooling can non-thermally induce cytocidal effects in cancer cells. To explore these effects, we assessed cell viability, DNA damage response pathways, and the percentage of mitotic cancer cells after near-infrared treatment. Further, we evaluated the anti-cancer effects of near-infrared irradiation compared with doxorubicin in xenografts in nude mice by measuring tumor volume and assessing protein phosphorylation by immunoblot analysis. The cell viability of A549 lung adenocarcinoma cells was significantly decreased after three rounds of near-infrared irradiation at 20 J ⁄ cm

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Non-Thermal Effects of Near-Infrared Irradiation on Melanoma

Cited by 20 publications

References 91 publications

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Protection from Near-Infrared to Prevent Skin Damage

Non‐thermal DNA damage of cancer cells using near‐infrared irradiation

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