Non‐thermal <scp>DNA</scp> damage of cancer cells using near‐infrared irradiation

Tanaka, Yohei; Tatewaki, Naoto; Nishida, Hiroshi; Eitsuka, Takahiro; Ikekawa, Nobuo; Nakayama, Jun

doi:10.1111/j.1349-7006.2012.02310.x

Cited by 30 publications

(33 citation statements)

References 32 publications

(47 reference statements)

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“…Therefore, various devices have been introduced to stimulate collagen production. I previously reported that near-infrared can penetrate deep into human tissue, achieve skin tightening and muscle thinning, and nonthermally induce various responses in the skin and subcutaneous tissues [4][5][6][7][8][9][10][11]. In addition, I previously reported that near-infrared or radiofrequency (RF) treatments stimulate collagen and elastin production while safely and effectively promoting long-lasting skin tightening results that decrease wrinkles and laxity [12,13].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Tanaka¹

2018

Dermatologic Surgery and Procedures

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Regardless of age, sex and skin type, skin tightening is a common procedure requested by patients seeking cosmetic treatments to improve facial contours and skin laxity. Radiofrequency has been proven to penetrate deeper than optical light sources independent of skin color and to be beneficial for skin tightening. I previously reported on the efficacy of multisource phase-controlled radiofrequency treatment and noninsulated microneedle radiofrequency applicator with fractionated pulse mode. The evaluation process was both subjective and objective; I evaluated objectively using threedimensional color schematic representation with quantitative volume measurements. These three-dimensional results showed significant improvement after the treatments. The post-treatment volume was drastically reduced as compared to the pretreatment volume. Most of the patients reported satisfaction with the improvement of skin laxity. The advantages of these multisource phase-controlled radiofrequency treatments are their long-lasting high efficacy of tightening effects, and the reduction of discomfort and side effects. These characteristics facilitate repeated treatments as well as provide safe and effective treatment of skin tightening.

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Section: Introductionmentioning

confidence: 99%

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Tanaka¹

2018

Dermatologic Surgery and Procedures

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“…These reports made it clear that infrared radiation could affect internal organs and hence the reproductive tissues were also at risk. Tanaka et al (2012) further demonstrated that the cell viability of cultured lung adenocarcinoma cells was significantly decreased after near-infrared irradiation at 20 J/cm, with increase in Apoptotic cells. In addition these researchers have shown that nearinfrared and doxorubicin inhibited the tumor growth of melanoma cells suggesting that nearinfrared irradiation can non-thermally induce cytocidal effects in cancer cells as a result of activation of the DNA damage response pathway.…”

Section: Adverse Effects -Caveats From Literaturementioning

confidence: 94%

Near-Infrared Radiaton: An All Pervading Yet Lesser Known Environmental Stressor

2017

International Journal of Research Studies in Medical and Health

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“…We previously reported that near-infrared can penetrate deep into human tissue, achieve skin tightening [2][3][4] and muscle thinning [5,6], and non-thermally induce various responses in the skin and subcutaneous tissues [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Objective Assessment of Skin Tightening Using Multisource, Phase-Controlled Radiofrequency in Asians

Tanaka¹

2013

JCDSA

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Background: Radiofrequency has been proven to penetrate deeper than optical light sources independent of skin color allowing a safer treatment for the Asian skin type. Many studies have indicated the efficacy of various types of devices, but have not included a sufficient objective evaluation. Multisource radiofrequency uses multiple phase controlled radiofrequency generators with real time impedance control, allowing painless, deeper dermal heating with better adaptation to differences in individual skin impedance. In this study we used three-dimensional imaging for the objective evaluation of facial skin tightening by multisource phase-controlled radiofrequency. Methods: Twenty Japanese patients were treated with a multisource phase-controlled radiofrequency device. Three-dimensional imaging was performed with a Canfield Scientific Vectra camera and software, and quantitative volume measurements were taken to evaluate the change in the post-treatment volume. The patients then provided subjective assessments. Results: Objective assessments of the treated cheek volume evaluated by a three-dimensional color schematic representation with quantitative volume measurements showed significant improvement three months after the final treatment. The mean volume reduction at the last post-treatment visit was 3.878 ± 2.86 mL. The post-treatment volume was significantly reduced compared to the pretreatment volume in all of the volunteers (P = 0.0007). Ninety-five percent of volunteers reported satisfaction with the improvement of skin laxity, and ninety percent of volunteers reported satisfaction with the improvement of wrinkles, such as the nasolabial folds. Conclusions: The advantages of these multisource phase-controlled radiofrequency treatments are its high efficacy for skin tightening associated with minimal level of discomfort, minimal side effects, and low cost. Taken together, these characteristics facilitate the ability to give repeated treatments as a stand alone treatment or adjunct to surgery. This study provides for the first time a qualitative and quantitative volumetric assessment, proving the ability of the technology to reduce the volume through non invasive skin tightening.

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Non‐thermal DNA damage of cancer cells using near‐infrared irradiation

Cited by 30 publications

References 32 publications

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Treatment of Skin Laxity Using Multisource, Phase-Controlled Radiofrequency

Near-Infrared Radiaton: An All Pervading Yet Lesser Known Environmental Stressor

Objective Assessment of Skin Tightening Using Multisource, Phase-Controlled Radiofrequency in Asians

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