Non-thermal ablation of rabbit liver VX2 tumor by pulsed high intensity focused ultrasound with ultrasound contrast agent: Pathological characteristics

Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling

“…Using pHIFU, the mechanical effects present in HIFU treatment become dominant over thermal effects. As an example, pHIFU has been successfully used by Zhou et al (C.-W. Zhou et al, 2008) to ablate rabbit liver in vivo nonthermally. For drug release, pHIFU can be used to mechanically activate nanoparticle drug carriers within a tight focal region (C.-W. Zhou et al, 2008).…”

Sonochemical catalysis as a unique strategy for the fabrication of nano-/micro-structured inorganics

“…Thereinto, low-frequency ultrasound (20.0-100.0 kHz) is usually called power ultrasound, and the majority of sonochemical processes as well as ultrasound-assisted surface treatment occurs in this frequency range, [3,18] for example, cleaning or decontamination is the most common use of lowfrequency ultrasound in a general chemistry laboratory. High-frequency ultrasound (0.5-10.0 MHz) is typically used in the medical applications for diagnosis and therapy, [19][20][21] for example, high-intensity focused ultrasound (HIFU) can be used in surgery to breakdown the blood clots or destroy the tumors when the ultrasound irradiation at an around 1.0 MHz frequency has aided the delivery of some nanodrugs. Figure 1 shows the general applications of ultrasound, and many of them are briefly explained in the chemical technology.…”

Superparamagnetic PLGA–iron oxide microspheres as contrast agents for dual-imaging and the enhancement of the effects of high-intensity focused ultrasound ablation on liver tissue

“…The animals were euthanized with intravenous 3% pentobarbital (1 mL kg À1 ) and sacriced immediately in an animal care facility aer HIFU ablation. The liver tissue was removed to perform TTC (2,3,5-triphenyltetrazolium chloride) solution staining 24 and to measure the coagulative necrosis volume (according to the method and the equation used for the ex vivo HIFU ablation of bovine liver). A 1 cm 3 sample was xed in 4% (W/V) paraformaldehyde for 24 h, embedded in paraffin, and stained with hematoxylin and eosin (HE).…”