Superparamagnetic PLGA–iron oxide microspheres as contrast agents for dual-imaging and the enhancement of the effects of high-intensity focused ultrasound ablation on liver tissue

Zhou, Di; Sun, Yong; Zheng, Yuanyi; Ran, Haitao; Li, Pan; Wang, Zhibiao; Wang, Zhigang

doi:10.1039/c5ra00880h

Cited by 14 publications

(12 citation statements)

References 52 publications

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“…A reduction of up to 98% in myoma volume and symptoms has been reported with MRI-guided HIFU for symptomatic myomas [7]. To increase the therapeutic efficiency of HIFU in achieving large ablation volume rapidly, various ultrasound contrast agents have been used with heating and cavitation effects, by modifying the acoustic environment in various tissues [8][9][10][11][12][13][14][15]. Among these, a phospholipid-shelled ultrasound contrast agent containing sulfur hexafluoride (SonoVue) is widely applied for diagnosis or evaluation after local ablation therapy in clinical settings, and assessed for enhancing the ablative effects of HIFU treatment [11,16,17].…”

Section: Discussionmentioning

confidence: 99%

Introducing clinical protocol for ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids in patients in Europe, provided from experienced Chinese center-prospective comparative

Dimitrov¹,

Zhou²,

Karamanliev³

et al. 2018

biomedicalresearch

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Introduction: This study aims to determine whether the Chinese clinical protocol, ultrasound guided high-intensity focused ultrasound (USgHIFU) combined with real-time monitoring using a contrast enhanced ultrasound (CEUS), also applies well in European patients with uterine fibroids. Methods: Seventy-five patients with 87 nodules of uterine fibroids from China and Bulgaria were treated with USgHIFU from April 2015 to July 2016, in the study. In Group A (Bulgarian) 26 (33 nodules) patients and in group B (Chinese) 49 (54 nodules) patients were included in the study. The same clinical procedure of USgHIFU treatment as well as a follow-up was performed on patients from China and Bulgaria. The general characteristics of the patients, the USgHIFU treatment and evaluation parameters, including; complications, fibroid size, tumor volume, subcutaneous fat size, non-perfused volume (NPV) and shrinkage process, were comparatively studied in Chinese and Bulgarian patients. Results: There were no significant differences in clinical parameters of Chinese and Bulgarian patients with uterine fibroids, such as vertical, left-right and аnterior-posterior size, treatment time, USgHIFU time.After USgHIFU treatment, no complications were recorded in both groups. On the 6 th and 12 th month after USgHIFU, fibroid nodules shrunk and the NPV was statistically significant compared to NPV before USgHIFU, but there were no statistically significant differences. Conclusions: The initial results of our study showed that CEUS clinical protocol for real time monitoring of efficacy and quality of the USgHIFU for uterine fibroid treatment that had been used in Chinese centers may also be applicable for European patients.

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Section: Discussionmentioning

confidence: 99%

Introducing clinical protocol for ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids in patients in Europe, provided from experienced Chinese center-prospective comparative

Dimitrov¹,

Zhou²,

Karamanliev³

et al. 2018

biomedicalresearch

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“…Whether the small NBs could induce larger lesions than MBs needs further studies using different shelled bubbles and different size of bubbles at high ultrasound pressure. Zhou et al used uSPIO/PLGA nanoparticles as contrast agents for the enhancement of the effects of HIFU ablation on liver tissue (Zhou et al, 2015). The uSPIO nanoparticles in the shell of the microspheres could boost the acoustic impedance to generate stronger ultrasound scattering and improve heating deposition in the targeted area.…”

Section: Discussionmentioning

confidence: 99%

“…At present, different sizes of gas-filled bubbles were introduced into the targeted region to enhance the therapeutic efficiency of HIFU thermal ablation and reduce side effects through changing the acoustic property of the targeted tissue, resulting in the ultrasound energy accumulation in the intended target region to damage the tissue (Hamano et al, 2014;Ma et al, 2014;Zhang et al, 2014;Zhou et al, 2015). Micrbubbles (MBs) are well known to be an important enhancer for synergistically and extensively accelerating the lesion formation of ultrasound-mediated heating and cavitation activity during HIFU treatment procedure (Luo et al, 2006;Peng et al, 20012).…”

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Comparison of the synergistic effect of lipid nanobubbles and SonoVue microbubbles for high intensity focused ultrasound thermal ablation of tumors (v0.2)"

2016

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Microbubbles (MBs) are considered as an important enhancer for high intensity focused ultrasound (HIFU) treatment of benign or malignant tumors. Recently, different sizes of gas-filled bubbles have been investigated to improve the therapeutic efficiency of HIFU thermal ablation and reduce side effects associated with ultrasound power and irradiation time. However, nanobubbles (NBs) as an ultrasound contrast agent for synergistic therapy of HIFU thermal ablation remain controversial due to their small nano-size in diameter. In this study, phospholipid-shell and gas-core NBs with a narrow size range of 500 to 600 nm were developed. The synergistic effect of NBs for HIFU thermal ablation was carefully studied both in excised bovine livers and in breast tumor models of rabbits, and made a critical comparison with that of commercial SonoVue microbubbles (SonoVue MBs). In addition, the pathological changes of the targeted area in tumor tissue after HIFU ablation were further investigated. Phosphate buffer saline (PBS) was used as the control. Under the same HIFU parameters, the quantitative echo intensity of B-mode ultrasound image and the volume of coagulative necrosis in lipid NBs groups were significantly higher and larger than that in PBS groups, but could not be demonstrated a difference to that in SonoVue MBs groups both ex vivo and in vivo. These results showed that the synergistic effect of lipid NBs for HIFU thermal ablation were similar with that of SonoVue MBs, and further indicate that lipid NBs could potentially become an enhancer for HIFU thermal ablation of tumors .

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“…Magnetic resonance imaging (MRI) is a powerful imaging technique with high spatial resolution and deep tissue penetration but is limited by low sensitivity [23][24][25] . Ultrasonic imaging (US) is a safe and convenient imaging tool with high sensitivity and high resolution, especially for structures and boundaries of soft tissue but is prone to interference [26][27][28] . Therefore, a nanocarrier with multimodal imaging abilities could offer more precise position of tumor sites for further cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Surface-engineered nanobubbles with pH-/light-responsive drug release and charge-switchable behaviors for active NIR/MR/US imaging-guided tumor therapy

Zhou

Zhang

et al. 2018

NPG Asia Mater

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Active drug-loaded nanocarriers have been widely employed as efficient drug delivery systems for tumor theranostics. Herein, we report folate-mediated "all-in-one" nanobubbles for tumor-targeted NIR/MR/US imaging and combined chemo-photothermal therapy. The surface-engineered nanobubbles are constructed from oleylamine-/IR-780-loaded hollow structures, folate and the Gd DTPA-BSA@5-FU complex via electrostatic adsorption and further filled with gas after freeze drying. DLS data show that the nanobubbles have a hydrodynamic diameter of 120.41 ± 18.30 nm. TEM observations show a hollow inner cavity and a shell thickness of approximately 10 nm. The relaxivity (r1) of the nanobubbles reaches 16.56 s −1 /mM, indicating suitable features for use as a T1-weighted MR contrast agent. Moreover, due to the gas core inside, the nanobubbles are suitable for ultrasound contrast imaging. Interestingly, ξpotential data and cumulative release measurements demonstrate that the nanobubbles undergo charge-switchable behaviors and pH-/light-sensitive drug-release behaviors after surface engineering, which could facilitate deep tumor penetration and accelerate drug release for efficient killing of cancer cells. In vivo trimodal imaging and chemophotothermal therapy for MGC-803 tumor-bearing mice reveal selective tumor accumulation, long tumor retention, and enhanced antitumor behaviors. Therefore, the all-in-one nanobubbles could be applied for active tumor-targeting theranostics.

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Superparamagnetic PLGA–iron oxide microspheres as contrast agents for dual-imaging and the enhancement of the effects of high-intensity focused ultrasound ablation on liver tissue

Abstract: Efforts have been made to develop a multifunctional platform that could provide both diagnostic information and a therapeutic effect.

Cited by 14 publications

References 52 publications

Introducing clinical protocol for ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids in patients in Europe, provided from experienced Chinese center-prospective comparative

Introducing clinical protocol for ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids in patients in Europe, provided from experienced Chinese center-prospective comparative

Peer Review #1 of "Comparison of the synergistic effect of lipid nanobubbles and SonoVue microbubbles for high intensity focused ultrasound thermal ablation of tumors (v0.2)"

Surface-engineered nanobubbles with pH-/light-responsive drug release and charge-switchable behaviors for active NIR/MR/US imaging-guided tumor therapy

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