Non-targeted metabolite profiling and specific targeted discrimination strategy for quality evaluation of Cortex Phellodendri from different varieties

Chen

et al. 2021

Aging

Self Cite

Parkinson's disease (PD), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN). However, no therapeutic agent used currently could slow down neuronal cell loss so as to decelerate or halt the progression of PD. Traditional Chinese medicine (TCM) has been utilized to treat the dysfunction of the autonomic nervous system. Wen-Shen-Yang-Gan decoction (WSYGD) has a good effect on the clinical treatment of PD with constipation. However, it is not clear which ingredients and what mechanism are responsible for the therapeutic effect. In this study, the pharmacodynamic study of WSYGD in PD mice was applied. Concurrently, a novel method for the identification of metabolic profiles of WSYGD has been developed. Finally, we found that WSYGD could protect the PD mice induced by rotenone. The underlying mechanism of the protective effect may be related to the reduction of the DA neurons apoptosis via reducing inflammatory reaction. By virtue of UPLC-MS and chemoinformatics method, 35 prototype compounds and 27 metabolites were filtered out and tentatively characterized. In conclusion, this study provides an insight into the metabolism of WSYGD in vivo to enable understanding of the metabolic process and therapeutic mechanism of PD.

Section: Characterization Of Mouse Metabolites Of Wsygdmentioning

confidence: 99%

UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson’s disease mice after oral administration of Wen-Shen-Yang-Gan decoction

Zhu

Chen

et al. 2021

Aging

Self Cite

“…Phellodendri Amurensis Cortex and Phellodendri Chinensis Cortex are obtained from the same genus but different varieties: Phellodendron amurese and P. chinense correspondingly. The discrimination research with PLS‐DA indicated that 17 prototype constituents and 22 metabolites were synergetic contributions for the group separation of the two types of medicines 68 …”

Section: Applications Of Chemometrics In Tcmmentioning

confidence: 99%

Pattern recognition: An effective tool for quality assessment of herbal medicine based on chemical information

Zuo

Journal of Chemometrics

2020

Herbal medicine has obtained great attention for its effective efficacy using its crude materials and patent medicines. It is believed that the efficacy is a synergetic action by several chemical components. To present a detailed overview of the usage of multivariate statistical techniques developed for analytical chemistry in quality assessment and origins traceability, we provided an extensive pragmatic and practical overview of these techniques for the quality control of these crude medicines. Two pattern recognition methods, unsupervised and supervised approaches, were interpreted using practical instances. Overall, the review briefly summarized common applications for location, species, harvesting time, processed production, manufacture, botanical part, and authenticity. Besides, we focused on data pretreatment and fusion strategies listing recently published literature to provide a detailed reference to choose the most appropriate statistical method and fusion strategies. Actual applications have proved chemometrics as an effective and rapid tool for the quality control of herbal medicine.

Ultrasound-assisted extraction of bioactive alkaloids from Phellodendri amurensis cortex using deep eutectic solvent aqueous solutions

Pan

et al. 2020

New J. Chem.