Non-surgical Periodontal Therapy With Adjunctive Topical Metronidazole + Piroxicam Gel Compared With Piroxicam Gel in the Treatment of Chronic Periodontitis

Farahmand, Amirhossein; Sayar, Ferena; Ghourbani, Mona; JafarzadehEsfahani, Bahareh; Ghanbarzadeh, Ali; Shirazi, Amirreza

doi:10.34172/ajdr.2019.01

Cited by 3 publications

(2 citation statements)

References 58 publications

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“…The current study and the study by Farahmand et al are consistent in showing that topical application of doxycycline as an adjunct to Scaling and Root Planning showed additional benefit in the treatment of chronic periodontitis. 18 However, in their study, doxycycline was used at a higher concentration than in our study, which showed the same therapeutic benefit at a lower concentration. In 2012, Pardeep et al presented their research on the effectiveness of four topical gels in the treatment of chronic periodontitis in India.…”

Section: Discussioncontrasting

confidence: 46%

“…Pocket depth in group C was 4.45±0.18 millimetres at baseline, 4.10±0.20 millimetres at day 10, and 4.06±0.27 millimetres after one month. Comparing pocket depth in groups A, B, and C on Day 10 revealed statistically significant differences (18). Groups A and B (Doxycycline and Metronidazole, respectively) had shallower pockets than Group C. (SRP alone).…”

Section: Resultsmentioning

confidence: 86%

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Novel adjunct treatment options of Periodontitis: Comparative effects of 0.4% Doxycycline and 1% Metronidazole.

Masood¹,

Ahmed

Javed

et al. 2023

TPMJ

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Objectives: To compare the efficacy of 1% Metronidazole gel to that of 0.4% Doxycycline gel in the adjunctive action of constant periodontitis. Study Design: Interventional study. Setting: Department of Periodontology at Isra Dental College Hyderabad. Period: January to June 2021. Material & Methods: Sixty individuals with persistent Periodontitis were selected using a non-probability convenience sample. Three sets of subjects were created. Group A received SRP in addition to 0.4% doxycycline gel, Group B received SRP in addition to 1% metronidazole gel, and Group C received SRP alone. A clinical parameter measuring CPITN probe is manually operated. Multiple surfaces were evaluated and ranked. Scaling and root planing were performed after thorough periodontal examinations. All patients got basic periodontal treatment, including oral hygiene training. Subgingival medication delivery was done by a disposible syringe and tiny needle. Each patient's baseline, 10-day, and 1-month clinical parameters were collected. SPSS 22.0 was used to examine proforma data. Results: Group A baseline pocket depth was 4.39 ±0.20 millimeters and decreased to 3.78 ±0.53 and 3.30±0.17 after one month. Group B baseline pocket depth was 4.45 ±0.19 millimeters and decreased to 3.89 ±0.51 and 3.340. At both the 10-day and 30-day marks, the growth was 17 mm. Starting at 4.45 ±0.18 mm, the pocket depth in Group C patients reduced to 4.10 ±0.20 mm by day 10 and to 4.06±0.27 mm at month's end. On the tenth day, the pockets were deep. Differed between A, B, and C. A and B had shallower pockets than C. Conclusion: Doxycycline and Metronidazole are more effective than scrubbing and root planing for chronic periodontitis. Both Doxycycline and metronidazole gels are equally effective for periodontitis patients.

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Section: Discussioncontrasting

confidence: 46%

Section: Resultsmentioning

confidence: 86%

Novel adjunct treatment options of Periodontitis: Comparative effects of 0.4% Doxycycline and 1% Metronidazole.

Masood¹,

Ahmed

Javed

et al. 2023

TPMJ

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Specific delivery of metronidazole using microparticles and thermosensitive in situ hydrogel for intrapocket administration as an alternative in periodontitis treatment

Maddeppungeng,

Syahirah,

Hidayati

et al. 2024

Journal of Biomaterials Science, Polymer Edition

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Piroxicam gel versus injectable platelet rich fibrin in the treatment of stage III periodontitis

Khallaf,

Sabra,

Ghoraba

et al. 2024

Tanta Dental Journal

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Background In view of the importance and prevalence of chronic periodontitis, there is still an urgent need to search for an effective therapy that is less expensive, easy to use, and readily available with no side effects. Injectable platelet rich fibrin (i-PRF) and piroxicam were considered as possible treatment options of periodontitis. Aim To evaluate the efficacy of piroxicam gel versus i-PRF in treatment of stage III periodontitis. Materials and method The current study was carried out as a randomized clinical trial. The participants diagnosed as having stage III, grade B periodontitis were selected from the patients attending Department of Periodontology and Oral Medicine, Faculty of Dentistry, Tanta University. The selected individuals randomly assigned into two groups (by means of a sealed envelope via masked supervisor): group I and group II. Forty sites (the deepest periodontal pockets) were selected. Twenty sites from GI was treated by piroxicam gel and 20 sites in GII were treated by i-PRF. The application was done 2 weeks after scaling and root planing and applied for five times one application every 2 weeks over 10 weeks. The comparison was assessed clinically and immunologically. Clinically, via recorded: probing pocket depth, clinical attachment loss, and bleeding on probing. Immunologically, via measuring: the levels of matrix metalloproteinases-8 in gingival cervical fluid samples. Clinical and immunological were recorded at baseline (before scaling and root planing), 4 weeks (2 weeks after first application), 8 weeks (at fourth application), and 12 weeks (2 weeks after the last application). Results Both groups showed significant improvement in all clinical and immunological parameters. Comparing GI and GII at each follow-up time point, there was significant amelioration in all assessed parameters in favor to GII. Conclusion The use of i-PRF is preferred over the use of piroxicam gel in the treatment of stage III chronic periodontitis, as it gives better clinical and immunological results.

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Non-surgical Periodontal Therapy With Adjunctive Topical Metronidazole + Piroxicam Gel Compared With Piroxicam Gel in the Treatment of Chronic Periodontitis

Abstract: Highlightsthe first recommended step and an essential phase of periodontal therapy (4). Conventional mechanical debridement cannot remove all the bacterial causes of periodontal diseases from the subgingival environment, particularly those inhabiting inaccessible regions such

Cited by 3 publications

References 58 publications

Novel adjunct treatment options of Periodontitis: Comparative effects of 0.4% Doxycycline and 1% Metronidazole.

Novel adjunct treatment options of Periodontitis: Comparative effects of 0.4% Doxycycline and 1% Metronidazole.

Specific delivery of metronidazole using microparticles and thermosensitive in situ hydrogel for intrapocket administration as an alternative in periodontitis treatment

Piroxicam gel versus injectable platelet rich fibrin in the treatment of stage III periodontitis

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