Novel adjunct treatment options of Periodontitis: Comparative effects of 0.4% Doxycycline and 1% Metronidazole.

Abstract

Objectives: To compare the efficacy of 1% Metronidazole gel to that of 0.4% Doxycycline gel in the adjunctive action of constant periodontitis. Study Design: Interventional study. Setting: Department of Periodontology at Isra Dental College Hyderabad. Period: January to June 2021. Material & Methods: Sixty individuals with persistent Periodontitis were selected using a non-probability convenience sample. Three sets of subjects were created. Group A received SRP in addition to 0.4% doxycycline gel, Group B received SRP in addition to 1% metronidazole gel, and Group C received SRP alone. A clinical parameter measuring CPITN probe is manually operated. Multiple surfaces were evaluated and ranked. Scaling and root planing were performed after thorough periodontal examinations. All patients got basic periodontal treatment, including oral hygiene training. Subgingival medication delivery was done by a disposible syringe and tiny needle. Each patient's baseline, 10-day, and 1-month clinical parameters were collected. SPSS 22.0 was used to examine proforma data. Results: Group A baseline pocket depth was 4.39 ±0.20 millimeters and decreased to 3.78 ±0.53 and 3.30±0.17 after one month. Group B baseline pocket depth was 4.45 ±0.19 millimeters and decreased to 3.89 ±0.51 and 3.340. At both the 10-day and 30-day marks, the growth was 17 mm. Starting at 4.45 ±0.18 mm, the pocket depth in Group C patients reduced to 4.10 ±0.20 mm by day 10 and to 4.06±0.27 mm at month's end. On the tenth day, the pockets were deep. Differed between A, B, and C. A and B had shallower pockets than C. Conclusion: Doxycycline and Metronidazole are more effective than scrubbing and root planing for chronic periodontitis. Both Doxycycline and metronidazole gels are equally effective for periodontitis patients.

The Effectiveness of Metronidazole Gels in the Management of Periodontal Disease

“…Untuk hasil terapi yang optimal, antibiotik dapat diberikan baik secara topikal maupun sistemik. 3 Pemberian terapi antimikroba secara sistemik, dalam pengelolaan pasien yang mengalami periodontitis, telah menunjukkan efek samping yang lebih sering terjadi. 4 Beberapa efek samping telah dilaporkan dari terapi antimikroba sistemik meliputi mual, ketidaknyamanan gastrointestinal, dan resistensi bakteri.…”