Non-steroidal anti-inflammatory drug for pulmonary administration: Design and investigation of ketoprofen lysinate fine dry powders

Surface-functionalized cockle shell–based calcium carbonate aragonite polymorph as a drug nanocarrier

“…In general, when ketoprofen lysinate drug concentrations were doubly reduced, the cell viability percentages increased, which indicates a decrease in the cytotoxic effect of the drug during 24 hours of incubation period (Figure 13A and B). Similar result of drug toxicity study58 that employed different cell lines was also reported.…”

A novel core–shell chronotherapeutic system for the oral administration of ketoprofen

“…Briefly, dried beads were added to the dissolution medium, 750 ml 0.1 M HCl for 2 h, then 25 ml of 0.2 M Na 3 PO 4 was added and pH adjusted to 6.8 as described in the USP 27/NF monograph "Drug release from delayed-release articles." Data were analyzed spectrophotometrically at a l of 258 nm for ketoprofen quantification [26]. Dissolution tests were conducted on six different batches of particles, and mean values were reported.…”

Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

“…[2][3][4][5] In the last few years, different technologies have been proposed for the development of controlled and delayed drug delivery systems. [6][7][8] Prilling (also known as laminar jet breakup) producing gel beads through vibrating nozzle extrusion is a time-saving technique, which offers several advantages compared with other microencapsulation technologies such as mild operative conditions (i.e., aqueous feed solutions, ambient temperature, and pressure) and an easy scale-up process. [9][10][11] In the present study, a gel beads formulation was designed for delayed delivery of ketoprofen using prilling as a microencapsulation technique and alginate as a polymer carrier.…”