Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

Cerciello, Andrea; Auriemma, Giulia; Morello, Silvana; Pinto, Aldo; Gaudio, Pasquale Del; Russo, Paola; Aquino, Rita Patrizia

doi:10.1002/jps.24554

Cited by 25 publications

(18 citation statements)

References 34 publications

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“…Male Wistar rats (180-220 g) were purchased from Charles River (Charles River Laboratories, Calco, Italy). To carry out the carrageenan oedema induction, rats were anaesthetized with isoflurane and oedema was induced by injecting 100 µL of carrageenan 1% (w/v) in the right hind paw, as previously reported [14]. The intensity of the oedema as well as its duration was assessed by rat paw volume measurements using plethysmometer (2Biological-Instruments, Italy) at time zero every hour up to 6 h and at 24 h after carrageenan injection.…”

Section: Carrageenan Oedema Inductionmentioning

confidence: 99%

“…Prilling is a mild and scalable microencapsulation technique working essentially through two steps: the breaking apart of a laminar jet of alginate solution into a row of mono-sized drops through a vibrating nozzle and the successive drops' ionotropic gelling in a solution of cations acting as crosslinkers. In the last few years, a large variety of gel-beads has been produced, varying the types of polysaccharides (mainly alginate, pectin, chitosan, and so on) used alone or in combination [10,11]; the configuration of the prilling apparatus to obtain 'only core' or core-shell beads [12]; and the gelling conditions in terms of cross-linker, pH of the reticulation solution, and gelling time [13,14]. Moreover, calcium alginate has often been used in combination with different gas-generating agents such as sodium bicarbonate, calcium carbonate, and citric acid or tartaric acid to obtain low-density floating formulations [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems

et al. 2020

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The aim of this research was to verify the application of alginate in combination with Ca2+ and Zn2+ ions to produce a floating and prolonged release system for the oral administration of prednisolone. Hollow and floating gel-beads were designed using prilling/ionotropic gelation as the microencapsulation technique, zinc acetate in the gelling solution as the alginate external crosslinker, and calcium carbonate in the feed as the internal crosslinking agent able to generate gas when in contact with the acidic zinc acetate solution. To achieve this goal, drug/alginate solutions were opportunely combined with different amounts of calcium carbonate. The effect of the addition of calcium carbonate into the feed solution on buoyancy, encapsulation efficiency, morphology, size distribution, as well as in vitro drug release profile of the alginate particles was studied. Moreover, the ability of the floating beads to modulate in vivo the anti-inflammatory response was assayed using the carrageenan-induced acute oedema in rat paw. The proposed strategy allowed obtaining alginate beads with extremely high encapsulation efficiency values (up to 94%) and a very porous inner matrix conferring buoyancy in vitro in simulated gastric fluid up to 5 h. Moreover, in vivo, the best formulation, F4, resulted in the ability to prolong the anti-inflammatory effect up to 15 h compared with raw prednisolone.

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Section: Carrageenan Oedema Inductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems

et al. 2020

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“…For the production of drug particles, pectin was selected as nontoxic, biocompatible and biodegradable polymer [15e17], ketoprofen, as anti-inflammatory drug model molecule [18,19]. The technique of prilling was selected among other methods of microencapsulation because it allows the production of spherical particles with a particle size distribution very narrow in mild operative conditions [20e22].…”

Section: Introductionmentioning

confidence: 99%

A novel core–shell chronotherapeutic system for the oral administration of ketoprofen

Cerciello

Auriemma

Gaudio

et al. 2016

Journal of Drug Delivery Science and Technology

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“…Usually they encapsulate the drug before the synthesis process. However, other developments observed higher values of encapsulation (i.e., ketoprofen in oral gels beads) with a EE of 53% . Kurbasic et al .…”

Section: Resultsmentioning

confidence: 98%

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Gaitán-Tolosa

Montiel-Campos

Flores-Estrada

et al. 2018

J of Applied Polymer Sci

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Polymer systems, in the form of crosslinking networks, have been widely used in biomedicine. However, they are a challenge mainly due to the impact of their physicochemical properties on release kinetics of drugs. Ketoprofen is an analgesic anti‐inflammatory drug with short half‐life (<2 h) and quickly eliminated by the body. Topical administration of ketoprofen can reduce pain, accelerate the wound healing process, and minimize the risk of systemic side effects. Therefore, the aim was to synthesize, characterize, and evaluate a novel ketoprofen polymer system in the form of a semi‐interpenetrated network of poly(ethylene glycol)‐chitosan. The pore size studied by small‐angle X‐ray scattering showed the presence of nanoscale pores, 13.7 nm (dry state) and 26.18 nm (swollen form). The maximum swelling was 420 ± 45% at 24 h. Finally, the encapsulated ketoprofen (6.5%) was released at a constant concentration (0.12 ± 0.03 mg/mL, 8 h) and half of the doses up to 24 h. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46644.

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Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

Cited by 25 publications

References 34 publications

Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems

Zinc and Calcium Cations Combination in the Production of Floating Alginate Beads as Prednisolone Delivery Systems

A novel core–shell chronotherapeutic system for the oral administration of ketoprofen

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

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