Non-steroidal anti-inflammatory and cytoprotective drug co-prescription in general practice

Clinard, François; Bardou, Marc; Sgro, C; Lefèvre, Nathalie; Raphaël, Francis; Paille, F.; Dumas, Monique; Hillon, Patrick; Bonithon‐Kopp, Claire

doi:10.1007/s00228-001-0378-5

Cited by 30 publications

(24 citation statements)

References 14 publications

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“…This figure was 21.7% in patients admitted to medical wards through an emergency department in Ireland in 1996 (median age, 70.5 years) [5]. In France, with a sample of 791 prescriptions from general practitioners from the Coˆte d'Or, co-prescription was found in 29.5% in 1999 [6]. More recently, in the USA, in a cohort of patients with arthritis treated with NSAIDs, 42% had a co-prescription [7].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, gastrointestinal damage caused by anti-inflammatory drugs is intended to be prevented. Various studies agree that NSAID utilization in Spain and other countries has markedly increased during the last decade [1,2,3,4,5,6,7]. It is estimated that in Spain approximately 4 million persons take NSAIDs more or less regularly to treat mild or moderate pain and inflammation [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Gastroprotection during the administration of non-steroidal anti-inflammatory drugs. A drug-utilization study

Carvajal

Arias

Vega

et al. 2004

Eur J Clin Pharmacol

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There has been an increase of anti-ulcer drug consumption in Spain. A high proportion of this consumption may be due to the use of those drugs as gastroprotective agents when co-prescribed with nonsteroidal anti-inflammatory drugs (NSAIDs). The aim of this study was to learn how these treatments are being used: the prevalence of use, the type of drug and the main features of patients. A sample of patients going to pharmacies with a NSAID prescription, with or without a gastroprotective agent, was obtained. A survey questionnaire was distributed to learn clinical and demographic data of the patients. Of the 942 patients interviewed, 41.6% were co-treated with a gastroprotective agent in addition to the NSAID. Most of these patients received proton-pump inhibitors and, to a lesser extent, histamine-2-receptor antagonists, antacids and prostaglandin analogues. The use of gastroprotective agents increased with age, treatment duration and illness chronicity; specialists prescribed a higher proportion of those co-treatments than did general practitioners. There was a high prescription rate of gastroprotective agents; in general, these were used according to recommendations. However, the type of gastroprotective agents being used does not seem to be justified by the current guidelines: histamine-2-receptor antagonists and antacid drugs have not proved their efficacy in this indication. The fact that one in four treatments with gastroprotective drugs was issued to patients without associated risk factors identifies a possible problem where an intervention could be appropriate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gastroprotection during the administration of non-steroidal anti-inflammatory drugs. A drug-utilization study

Carvajal

Arias

Vega

et al. 2004

Eur J Clin Pharmacol

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“…Data on the use of preventive strategies in NSAID users in several countries have been published, but all studies used different designs, outcome measures, populations and definitions for at-risk NSAID users. [6][7][8][9][10] Hence, it is impossible to compare adherence to preventive strategies across countries directly or to aggregate results. In the before-mentioned study from the Netherlands, we further observed that there was a significant, but temporal, decrease in use of gastroprotection in at-risk NSAID users after 2004.…”

Section: Introductionmentioning

confidence: 99%

Prescription of nonselective NSAIDs, coxibs and gastroprotective agents in the era of rofecoxib withdrawal ‐ a 617 400‐patient study

Valkhoff

Soest²,

Masclee

et al. 2012

Aliment Pharmacol Ther

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most frequently prescribed drugs, particularly in the field of orthopedics (1). Twenty million Americans regularly use NSAIDs, and more than 111 million prescriptions for NSAIDs are written each year (2).…”

Section: Introductionmentioning

confidence: 99%

Prescription of Nonsteroidal Anti-inflammatory Drugs and Co-prescribed Drugs for Mucosal Protection: Analysis of the Present Status Based on Questionnaires Obtained from Orthopedists in Japan

et al. 2007

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Non-steroidal anti-inflammatory and cytoprotective drug co-prescription in general practice

Abstract: Although a large majority of GP prescriptions were in accordance with official recommendations, inadequate NSAID prescription practices remain relatively frequent especially with regard to the elderly.

Cited by 30 publications

References 14 publications

Gastroprotection during the administration of non-steroidal anti-inflammatory drugs. A drug-utilization study

Gastroprotection during the administration of non-steroidal anti-inflammatory drugs. A drug-utilization study

Prescription of nonselective NSAIDs, coxibs and gastroprotective agents in the era of rofecoxib withdrawal ‐ a 617 400‐patient study

Prescription of Nonsteroidal Anti-inflammatory Drugs and Co-prescribed Drugs for Mucosal Protection: Analysis of the Present Status Based on Questionnaires Obtained from Orthopedists in Japan

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