Non‐specific airway hyperresponsiveness in mono‐sensitive Sicilian patients with allergic rhinitis. Its relationship to total serum IgE levels and blood eosinophils during and out of the pollen season

Lorenzo, Gabriele Di; Mansueto, Pasquale; Melluso, M.; Morici, Giuseppe; Norrito, F.; Pellitteri, Maria Esposito; Salvo, Alessandra Di; Colombo, Alfredo; Candore, Giuseppina; Caruso, Calogero

doi:10.1111/j.1365-2222.1997.tb01257.x

Cited by 46 publications

(57 citation statements)

References 36 publications

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“…IL5, IL18 blood levels, blood and sputum count of eosinophils have been shown to increase during pollen season and to parallel bronchial hyperresponsiveness (14,15,(18)(19)(20). Given these observations, the stability of proinflammatory cytokines during and outside the pollen season in our study are consistent with the absence of cypress pollen induced bronchial hyperresponsiveness in the majority of patients.…”

Section: Systemic Inflammationsupporting

confidence: 78%

“…Secondly, in pollen induced rhinitis, lower airways impairment may depend on the pollen species. Di Lorenzo and colleagues brought out that bronchial hyperresponsiveness incidence among allergic rhinitis patients during pollen season and off season depend on the kind of pollen responsible for the allergy (14). In this study conducted on 49 patients with Parietaria, Gramineae and Olea pollen induced rhinitis, the authors conclude that Parietaria pollen allergy is more important than Gramineae or Olea pollen allergy as a risk of developing nonspecific bronchial hyperresponsiveness, measured as response to inhaled methacholine.…”

Section: Implication For Diagnosis and Therapeutic Managementmentioning

confidence: 74%

“…lergen involved (10)(11)(12)(13). Within pollen-induced allergic rhinitis, importance has to be paid to the pollen species (14,15). Guidelines of clinical management have been built on available evidence, mostly based on grass pollen allergy studies.…”

mentioning

confidence: 99%

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Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis

Pahus

Gouitaa²,

Sofalvi³

et al. 2018

Eur Ann Allergy Clin Immunol

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Section: Systemic Inflammationsupporting

confidence: 78%

Section: Implication For Diagnosis and Therapeutic Managementmentioning

confidence: 74%

See 1 more Smart Citation

Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis

Pahus

Gouitaa²,

Sofalvi³

et al. 2018

Eur Ann Allergy Clin Immunol

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“…Eosinophilia was observed in 32 rice mill workers (26.7 %) in the current study. Di Lorenzo et al [42] reported that there is an inter-relationship of the allergen type, total serum IgE, eosinophil and bronchial hyper-responsiveness suggesting that all three may play a role in the development of bronchial asthma. According to Halonen et al [43], a significant relationship exists between serum IgE levels and eosinophilia in populations presumed to be free of parasites where IgE levels presumably provide a better clue to atrophy than skin tests.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of respiratory symptoms and disorders among rice mill workers in India

Ghosh¹,

Gangopadhyay

Das

2014

Environ Health Prev Med

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Objectives Lung function tests have become an integral part of assessment of pulmonary disease. Diseases of the respiratory system induced by occupational dusts are influenced by the duration of exposure. The aim of the study is to investigate the impairment of lung function and prevalence of respiratory symptoms among the rice mill workers. Methods A total of 120 rice mill workers from three districts of Karnataka were included in this study. Fifty urban dwellers from the same socio-economic level were selected as controls. The study included clinical examination, assessment of respiratory symptoms, pulmonary function test, measurement of peak expiratory flow rate, absolute eosinophil count, ESR estimation, total IgE estimation and radiographic test. Results The present study has shown that the rice mill workers complained of several types of respiratory disorders like phlegm (40.8 %), dyspnea (44.2 %), chest tightness (26.7 %), cough (21.7 %), and nose irritation (27.5 %). Rice mill workers exposed to dust presented significantly (p \ 0.05) lower levels of FVC (3.44 ± 0.11), FEV 1 (2.73 ± 0.15) and PEFR (304.95 ± 28.79) than the controls. The rice mill workers are having significantly higher absolute eosinophil counts, total IgE and ESR than control groups. The hematological findings suggest that the harmful effects may be linked to both non-specific irritation and allergic responses to rice husk dust among rice mill workers. Conclusion Dust exposure in the working environment affects the lung function values and increased the respiratory symptoms among the rice mill workers.

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“…12,13 The response to ASI was determined clinically by asking the patient the following: ''Do you feel better than you did before therapy?'' The answer could be one of the following:…”

Section: Vasmentioning

confidence: 99%

Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen-specific immunotherapy

Lorenzo

Mansueto

Pacor

et al. 2009

Journal of Allergy and Clinical Immunology

170

148

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Background: To date, no predictive tests for the clinical response to allergen-specific immunotherapy (ASI) are available. Therefore an in vivo or in vitro test would be of great value. Objective: We sought to evaluate pretreatment parameters used in diagnosing allergic rhinitis and determining serum specific IgE (s-IgE) levels, serum total IgE (t-IgE) levels, and blood eosinophil counts and to identify whether can be used to predict clinical improvement in monosensitized patients with allergic rhinitis with or without asthma treated with immunotherapy. Methods: We analyzed 279 patients who had undergone 4 years of ASI administered either by means of the subcutaneous immunotherapy (76 patients) or sublingual immunotherapy (203 patients) routes. Serum t-IgE and s-IgE levels, blood eosinophil counts, and serum s-IgE/t-IgE ratios were calculated and tested for correlation with clinical response to ASI. Receiver operating characteristic curves were determined. Predicted probabilities and predictive areas under the curve were calculated. Results: The clinical response to ASI was effective in 145 (52.0%) of 279 total patients, 42 (55.2%) of 76 patients treated with subcutaneous immunotherapy, and 103 (50.7%) of 203 patients treated with sublingual immunotherapy. A significant correlation was found between the serum s-IgE/t-IgE ratio and the clinical response to ASI, with high ratios (>16.2) associated with an effective response. The sensitivity and specificity of the area under the curve of the ratio were higher than those of serum s-IgE and t-IgE alone. Conclusion: The calculation of the serum s-IgE/t-IgE ratio for predicting the clinical response to ASI offers an advantage over measuring t-IgE and s-IgE levels in monosensitized patients for the following allergens: grass, Parietaria judaica,

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Non‐specific airway hyperresponsiveness in mono‐sensitive Sicilian patients with allergic rhinitis. Its relationship to total serum IgE levels and blood eosinophils during and out of the pollen season

Cited by 46 publications

References 36 publications

Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis

Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis

Prevalence of respiratory symptoms and disorders among rice mill workers in India

Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen-specific immunotherapy

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