Non‐smoking‐related chronic obstructive pulmonary disease: A neglected entity?

Sun, Baoqing; Sun, Baoqing; Zhong, Nanshan

doi:10.1111/j.1440-1843.2012.02152.x

Cited by 68 publications

(51 citation statements)

References 49 publications

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“…However, previous studies mainly focused on COPD in smokers, studies of non-smoking COPD were limited [7]. The mechanism of COPD, especially in never-smokers, and the biomarkers and therapeutic targets of this disease at molecular levels have become targets of interest.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of miRNA-mRNA-lncRNA Networks in Non-Smoking and Smoking Patients with Chronic Obstructive Pulmonary Disease

Qian¹,

Mao²,

Shi³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. This study aimed to identify overlapping or diverging dysregulated genes, lncRNAs, miRNAs and signaling pathways in smoking and non-smoking chronic obstructive pulmonary disease (COPD). Methods: Compared to normal controls, we identified the shared and divergent differentially expressed mRNAs (DEmRNAs), miRNAs (DEmiRNAs) and lncRNAs (DElncRNAs) in smoking and non-smoking COPD by RNA-sequencing and bioinformatics analysis. Functional annotation of DEmRNAs were performed. Both cis and trans-target DEmRNAs of DElncRNAs were identified. The target DEmRNAs of DEmiRNAs were identified as well. The DEmiRNA-DEmRNA-DElncRNA interaction network was constructed. QRT-PCR was performed to validat the selected DEmiRNAs, DEmRNA and DElncRNAs in COPD. Results: Compared to normal control, 1234 DEmRNAs, 96 DElncRNAs and 151 DEmiRNAs were identified in non-smoking patients with COPD; 670 DEmRNAs, 44 DElncRNAs and 63 DEmiRNAs were identified in smoking patients with COPD. Leukocyte transendothelial migration and pathways in cancer were significantly enriched pathways in non-smoking and smoking COPD, respectively. MiR-122-5p-A2M-LINC00987/A2M-AS1/ linc0061 interactions might play key roles in COPD irrespective with the smoking status. Let-7-ADRB1-HLA-DQB1-AS1 might play a key role in the pathogenesis of smoking COPD while miR-218-5p/miR15a-RORA-LOC101928100/LINC00861 and miR-218-5p/miR15a-TGFβ3-RORA-AS1 interactions might involve with non-smoking COPD. Conclusion: We identified the shared and diverging genes, lncRNAs, miRNAs and their interactions and pathways in smoking and non-smoking COPD which provided clues for understanding the mechanism and developing novel diagnostic and therapeutic strategies for COPD.

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Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of miRNA-mRNA-lncRNA Networks in Non-Smoking and Smoking Patients with Chronic Obstructive Pulmonary Disease

Qian¹,

Mao²,

Shi³

et al. 2018

Cell Physiol Biochem

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“…Globally, a noticeable proportion of COPD cases are known to be nonsmokers, ranging from 22.9% in UK ( 6 ) to 47% in South Africa ( 5 ). In India specifi cally, 69% of COPD cases were found to be never smokers in a study conducted on 1200 slum dwellers in Pune, Maharashtra ( 7 ).…”

Section: Introductionmentioning

confidence: 98%

“…Th is in turn has over shadowed the importance of other lifestyle and environmental risk factors ( 5 ). Recent evidences suggest that non-smoking related COPD is higher than previously believed, particularly in the low and middle income countries (LMICs), accounting for 1/4 th to 1/3 rd of all COPD cases ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and its Non-Smoking Risk Factors in India

Walia

Vellakkal

Gupta

2015

COPD: Journal of Chronic Obstructive Pulmonary Disease

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The rising prevalence of the chronic obstructive pulmonary disease (COPD) is generally attributed to smoking, since the role of other risk factors among non-smokers are not well established especially in low and middle income countries like India. This is also reflected by the limited literature available on non-smoking related COPD risk factors like indoor and outdoor air pollution. The present review is an attempt to assess the influence of non-smoking risk factors on COPD and its measures in Indian subcontinent. The most noteworthy factors among non-smokers appear to be the use of biomass fuel for cooking and heating purposes. We observed that the studies undertaken to evaluate the role of such risk factors are inconclusive due to weak methodologies and small sample sizes, may be due to limited financial resources. The present review suggests the need of a nationally representative study to estimate the effect of each of the potential modifiable risk factor (other than smoking) for framing impactful public health policies to prevent and manage COPD at community and population level in India.

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“…(9) Risk factors for COPD in nonsmokers may include genetic factors, longstanding asthma, outdoor air pollution (from traffic and other sources), environmental tobacco smoke exposure, biomass smoke exposure, occupational smoke exposure, diet, recurrent respiratory infection in early childhood and tuberculosis. (10) Nonsmoking COPD is a neglected entity typically excluded in clinical trials, with a lack of characterisation of its profile. …”

Section: Smoker's Disease or Diseased Smoker?mentioning

confidence: 99%

Re-emergence of chronic obstructive pulmonary disease: it is time to think COPDifferently

Tee

2013

smedj

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Knowledge of chronic obstructive pulmonary disease (COPD) as a common, preventable and treatable condition has advanced in the last two decades, as evidenced by the increase in scientific literature. Tobacco smoking still remains a predominant risk factor for COPD. Thus smoking cessation management should be obligatory in every case. Although spirometry is integral to the diagnosis of COPD, one should also be aware of its limitations. COPD is a chronic disease associated with comorbidities that define its extrapulmonary manifestations. Systemic inflammation provides the biological link, while exacerbations play a prominent role in the current approach to disease evaluation. This paper reviews the latest Global Initiative for Chronic Obstructive Pulmonary Disease revision, focusing on the paradigm shift in assessment that would directly influence therapeutic decisions. Also discussed are the newer drugs and combinations of existing inhaler therapies that now present clinicians with more options, as well as bronchoscopic interventions that may perhaps offer a lower-morbidity alternative than surgical lung volume reduction. Finally, this review highlights how integrated care models can bridge the gap between components and complete a comprehensive sphere of COPD care.

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Non‐smoking‐related chronic obstructive pulmonary disease: A neglected entity?

Cited by 68 publications

References 49 publications

Comprehensive Analysis of miRNA-mRNA-lncRNA Networks in Non-Smoking and Smoking Patients with Chronic Obstructive Pulmonary Disease

Comprehensive Analysis of miRNA-mRNA-lncRNA Networks in Non-Smoking and Smoking Patients with Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease and its Non-Smoking Risk Factors in India

Re-emergence of chronic obstructive pulmonary disease: it is time to think COPDifferently

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